STUDIES IN COMPARATIVE NEUROPHYSIOLOGY

比较神经生理学研究

• 批准号: 3393186
• 负责人: THEODORE H BULLOCK
• 金额: $ 20.12万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1975
• 资助国家: 美国
• 起止时间: 1975-06-27 至 1990-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3393186
• 关键词: afferent nerve; aquatic organism; auditory feedback; brain electrical activity; brain stem; cerebellum; cerebrum; electrical potential; electrophysiology; evoked potentials; evolution; fluorescent dye /probe; fresh water environment; histochemistry /cytochemistry; mesencephalon; neural information processing; neuroanatomy; neurophysiology; prosencephalon; saltwater environment; sensory feedback; sensory mechanism; thalamus; vestibular apparatus

The long term objectives are to give perspective on the human brain and how it evolved, in respect to mechanisms of integration of neural activity in organized assemblies of neurons in the central nervous system, including macro- and local circuits. The specific aims are to use the comparative approach with model systems in lower vertebrates to examine selected neural achievements or structures, including in particular sensory processing, encoding, decoding, filtering, parallel information channels, interactions among modalities and extraction of useful signals at various levels, from first order to cerebral. The octavolateralis system of senses (eighth nerve and lateral line) and the cerebellum and higher centers receiving its modalities are a special focus. Receptors and brain structures analyzing acoustic, vibratory, gravity, acceleration, water movement and weak electric field stimuli, in favorable species of elasmobranchs, teleosts and other vertebrates will be the materials. They will be studied with the following, mainly physiological but partly anatomical methods. (i) Recording from single units and multiple units with single electrodes and arrays of multiple electrodes. (ii) Recording from populations of cells as extracellular fields of ongoing as well as evoked activity, with computer displays of histograms, cross correlations, averaged activity, power spectra, coherence, envelopes of bandpass filtered activity, spectra and cross correlations of the envelopes of different bands and other descriptors that might distinguish lower and higher levels of organization. (iii) Injection of peroxidase, cobalt, fluorescent dyes or radioactive amino acids and histochemical visualization of sites of lesions. This project will normally occupy 2 students, 3 postdoctoral visitors, the P.I., an engineer, technician and secretary. Continued collaboration with former visiting scientists as well as new collaboration with local and distant colleagues are planned.

长期目标是提供对人类大脑的看法，以及如何 它的进化，在神经活动的整合机制方面， 中枢神经系统中神经元的有组织组装，包括 宏电路和本地电路。 具体目标是使用比较 在低等脊椎动物中使用模型系统的方法来检查选定的神经 成就或结构，特别包括感觉处理， 编码，解码，过滤，并行信息通道，交互 在各种形式和提取有用的信号，从 一级脑损伤 感觉的octavolateralis系统（第八 神经和侧线）和小脑和更高的中心接受其 模式是一个特别的重点。 受体和大脑结构分析 声学、振动、重力、加速度、水运动和弱 电场刺激，在板鳃类，硬骨鱼和 其他脊椎动物将是材料。 他们将研究与 主要是生理学方法，但部分是解剖学方法。 （一） 使用单电极从单个装置和多个装置记录， 多个电极的阵列。 (ii)从细胞群记录为 细胞外领域的持续以及诱发活动，与计算机 显示直方图、互相关、平均活动、功率 光谱、相干性、带通滤波活性的包络、光谱和 不同波段包络的互相关和其他 可能区分较低和较高水平的 organization. (iii)注射过氧化物酶、钴、荧光染料或 放射性氨基酸和组织化学可视化的网站， 病变 该项目通常将占用2名学生，3名博士后 访客私家侦探工程师、技术员和秘书。 继续 与前访问科学家的合作以及新的合作 与当地和远方的同事进行交流。