CHILDHOOD RISK FACTORS FOR ADULT MENTAL DISORDERS

成人精神障碍的儿童期风险因素

• 批准号: 3382673
• 负责人: ALEX E SCHWARTZMAN
• 金额: $ 29.13万
• 依托单位: CONCORDIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3382673
• 关键词: aggression; antisocial personality; disease /disorder proneness /risk; early diagnosis; gender difference; human subject; longitudinal human study; mental disorder diagnosis; mental disorders; mental health epidemiology; middle childhood (6-11); prognosis; schizophrenia; social adjustment; social behavior disorders; socioeconomics; young adult human (21-34)

The purpose of this prospective epidemiological study is to determine whether childhood aggression and social withdrawal are risk factors for mental illness in adulthood. In addition, we are examining whether other negative outcomes, such as social and occupational maladjustment are associated with these patterns of deviant behaviors. Four risk populations are being studied: individuals who as children were aggressive, withdrawn, or both aggressive and withdrawn, and a control sample of individuals who as children were not deviant on either characteristic. These individuals were initially identified in middle childhood when they ranged in age from 6 to 13 years. During this phase of the project, they will be in early adulthood, ranging in age from 21 to 28 years. We have adopted a multilevel data collection strategy. Data will be collected by means of (1) archival records, (2) visits by lay interviewers to individuals' homes to identify psychopathology and to collect additional information predictive of psychiatric distress, such as life stress and social support, and (3) visits by participants to the laboratory for psychiatric interviews conducted by experienced clinicians to obtain detailed psychiatric diagnostic data, and for laboratory tests to obtain information about attention deficits that are frequently associated with major psychopathology. The study is unusual in the large size of the prospective cohort (1,774). It will be possible to detect elevations in risk factors for psychiatric disorders with relatively high prevalence, such as substance use, and for psychiatric disorders with relatively low prevalence, such as, schizophrenia-spectrum disorders. The study is also unusual in having a large representation of females in the risk groups. In the past, particularly in the study of aggression or conduct disorders, it has been common for studies to be base predominantly on male samples. The timing of this phase of the study is propitious. We have the opportunity to assess individuals at the beginning of adulthood. Combined with data from subsequent planned phases of the project that will follow individuals through the period of highest risk for major psychopathology, we will be able to trace the development of individuals from childhood risk factors, to early experiences as adults predictive of psychopathology (e.g. life stress) to the identification of the age of onset of adult mental disorders.

这项前瞻性流行病学研究的目的是 确定儿童时期的攻击性和社交退缩是否是 成年期精神疾病的危险因素。 此外，我们还 检查是否存在其他负面结果，例如社会和 职业失调与这些模式有关 越轨行为。 正在研究四个风险人群： 孩子们表现出攻击性、内向性或既攻击性又孤僻 孤僻的人，以及童年时期的人的对照样本 任何一个特征都没有偏差。 这些人是 最初在童年中期被发现，当时他们的年龄不等 6至13岁。 在项目的这个阶段，他们将 处于成年早期，年龄从 21 岁到 28 岁不等。 我们采用了多层次的数据收集策略。 数据会 通过 (1) 档案记录、(2) 外行访问来收集 访谈者到个人家中识别精神病理学并 收集预测精神病学的额外信息 困扰，例如生活压力和社会支持，以及 (3) 探访 由参与者到实验室进行精神病学访谈 由经验丰富的临床医生进行，以获得详细的精神科资料 诊断数据，以及实验室测试以获得信息 关于经常与重大问题相关的注意力缺陷 精神病理学。 这项研究的前瞻性队列规模之大是不同寻常的 （1,774）。 将有可能检测到风险因素的升高 对于患病率相对较高的精神疾病，例如 物质使用，以及相对较低的精神疾病 患病率，例如精神分裂症谱系障碍。 研究 女性在该领域的比例也很高，这一点也是不寻常的。 风险群体。 过去，特别是在攻击性研究中 或行为障碍，研究通常是基础性的 主要针对男性样本。 这一阶段研究的时机是有利的。 我们有 在成年初期评估个人的机会。 结合项目后续计划阶段的数据 它将跟踪个人度过最高风险时期 主要的精神病理学，我们将能够追踪其发展 个体从童年危险因素到早期经历 成年人对精神病理学（例如生活压力）的预测 确定成人精神障碍的发病年龄。