X-ray induced photoacoustic nanoprobe: Break depth dependency of bioimaging

X 射线诱导光声纳米探针：生物成像的断裂深度依赖性

• 批准号: DE170100092
• 负责人: Dr Run Zhang
• 金额: $ 26.03万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-09 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE170100092
• 关键词: ray; induced; photoacoustic; nanoprobe; Break

This project aims to develop a nanoprobe using an X-ray excited luminescence “nanolaser” as the local light source to activate coupled responsive photoacoustic sensors. In-situ imaging of specific biomarkers at the molecular level is key to understanding their roles in physiological and pathological processes, but current imaging techniques using fluorescent probes cannot detect biomarkers in deep tissues due to shallow light penetration. By capitalising on the tissue penetrating property of X-rays and acoustic waves and collecting acoustic waves as the read-out signal, real-time monitoring of biomarkers in deep tissues could be achieved, advancing detection technology for deep-tissue biomarkers.

本项目旨在开发一种纳米探针，使用X射线激发发光“纳米激光器”作为本地光源来激活耦合响应光声传感器。在分子水平上对特定生物标志物进行原位成像是了解其在生理和病理过程中作用的关键，但由于光穿透较浅，目前使用荧光探针的成像技术无法检测深层组织中的生物标志物。通过利用X射线和声波的组织穿透特性，并收集声波作为读出信号，可以实现对深部组织中生物标志物的实时监测，推进深部组织生物标志物的检测技术。