Optical and Acoustic Imaging for Interventional Device Guidance

用于介入设备引导的光学和声学成像

• 批准号: EP/J010952/1
• 负责人: Adrien Desjardins
• 金额: $ 14.71万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FJ010952%2F1
• 关键词: Optical; Acoustic; Imaging; Interventional; Device

Medical needles are central to a wide range of diagnostic and therapeutic interventions, including tissue biopsies and injections of anaesthesia. Accurately and efficiently reaching deep tissue targets can be very challenging. Many needle insertions are performed with ultrasound imaging systems that are exterior to the body, and with the sense of touch that is relayed via the needles to a physician's hands. These techniques are often insufficient for directly detecting the tissue targets, however, and consequently there is a risk of inaccurate needle placement. For instance, with biopsies of the prostate, the suspected cancerous lesions may not be visible with ultrasound imaging, and consequently the biopsies may be obtained from incorrect locations. As a new Lecturer at the Department of Medical Physics and Bioengineering at UCL, one of my primary objectives is to transform medical needles so that they that can provide molecular information about tissue and thereby significantly improve the accuracy of needle-based procedures. Leveraging recent advances in optical telecommunications technologies, these needles will deliver brief light pulses to tissues at their tips. By virtue of the photoacoustic effect, absorption of light pulses will generate sound waves that can be detected and converted into images of molecular absorption in real-time. The research programme kick-started by an EPSRC First Grant will ultimately lead to the development of a broad range of medical devices that could directly detect tissue targets and critical structures to improve clinical outcomes and decrease the risks of complications.

医用针是各种诊断和治疗干预的核心，包括组织活检和麻醉注射。准确有效地到达深层组织目标可能非常具有挑战性。许多针插入是通过体外的超声成像系统进行的，并且通过针将触觉传递到医生的手上。然而，这些技术通常不足以直接检测组织目标，因此存在针放置不准确的风险。例如，对于前列腺活检，超声成像可能看不到可疑的癌性病变，因此可能从不正确的位置获得活检。作为伦敦大学学院医学物理和生物工程系的新讲师，我的主要目标之一是改造医用针头，使其能够提供有关组织的分子信息，从而显着提高基于针头的手术的准确性。利用光通信技术的最新进展，这些针将在其尖端向组织传送短暂的光脉冲。凭借光声效应，吸收光脉冲会产生声波，声波可以被实时检测并转换成分子吸收的图像。该研究项目由 EPSRC 首次拨款启动，最终将开发出多种医疗设备，这些设备可以直接检测组织目标和关键结构，以改善临床结果并降低并发症的风险。

项目成果

Gel wax-based tissue-mimicking phantoms for multispectral photoacoustic imaging.

• DOI: 10.1364/boe.9.001151
• 发表时间: 2018-03-01
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Maneas E;Xia W;Ogunlade O;Fonseca M;Nikitichev DI;David AL;West SJ;Ourselin S;Hebden JC;Vercauteren T;Desjardins AE
• 通讯作者: Desjardins AE

Laser-generated ultrasound with optical fibres using functionalised carbon nanotube composite coatings

• DOI: 10.1063/1.4873678
• 发表时间: 2014-04-28
• 期刊: APPLIED PHYSICS LETTERS
• 影响因子: 4
• 作者: Colchester, Richard J.;Mosse, Charles A.;Desjardins, Adrien E.
• 通讯作者: Desjardins, Adrien E.

Carbon-Nanotube-PDMS Composite Coatings on Optical Fibers for All-Optical Ultrasound Imaging

• DOI: 10.1002/adfm.201601337
• 发表时间: 2016-12-13
• 期刊: ADVANCED FUNCTIONAL MATERIALS
• 影响因子: 19
• 作者: Noimark, Sacha;Colchester, Richard J.;Desjardins, Adrien E.
• 通讯作者: Desjardins, Adrien E.

Interventional multispectral photoacoustic imaging with a clinical ultrasound probe for discriminating nerves and tendons: an ex vivo pilot study.

• DOI: 10.1117/1.jbo.20.11.110503
• 发表时间: 2015-11
• 期刊: Journal of biomedical optics
• 影响因子: 3.5
• 作者: Mari JM;Xia W;West SJ;Desjardins AE
• 通讯作者: Desjardins AE