A Miniaturized and High-frequency Acoustic Imaging System for Oral Health and Diseases of the Head and Neck

用于口腔健康和头颈疾病的小型化高频声学成像系统

• 批准号: 10346895
• 负责人: Jesse Vincent Jokerst
• 金额: $ 66.41万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-21 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10346895
• 关键词: 3-Dimensional; 3D Print; Address; Algorithms; American; Cadaver; California; Canis familiaris; Cardiovascular system; Clinical; Clinical assessments; Collaborations; Complement; Consumption; Data; Dental; Dental Care; Dental Enamel; Dental General Practice; Dentists; Devices; Diagnosis; Dimensions; Disease; Dose; Endoscopic Ultrasonography; Endoscopy; Equipment; Family suidae; Frequencies; Funding; Gingiva; Goals; Gold; Head and neck structure; Health; Health Professional; Hockey; Housing; Human; Hypoxia; Image; Imaging Device; Imaging technology; Implant; Incisor; Industrialization; Inflammation; Investments; Ionizing radiation; Jaw; Lasers; Lateral; Letters; Licensing; Light; Malignant Neoplasms; Maps; Measurement; Measures; Methods; Modality; Monitor; Mouth Diseases; Neck Disorder; Needles; Operative Surgical Procedures; Oral cavity; Oral health; Outcome; Pain; Patients; Performance; Perfusion; Periodontal Diseases; Periodontitis; Periodontium; Physiologic pulse; Prevalence; Process; Provider; Quality of life; Recording of previous events; Resolution; Risk; Source; Surface; System; Technology; Thick; Time; Tissues; Tooth Cervix; Tooth structure; Transducers; Translating; Ultrasonic Transducer; Ultrasonography; United States National Institutes of Health; Universities; Validation; Variant; Widespread Disease; Work; acoustic imaging; alveolar bone; base; bone; clinical translation; commercialization; design; health application; human data; human disease; human subject; image processing; imaging approach; imaging system; improved; in vivo imaging system; industry partner; innovation; insight; miniaturize; miniaturized device; non-invasive imaging; photoacoustic imaging; radiological imaging; soft tissue; standard of care; tool; treatment planning; ultrasound

PROJECT SUMMARY Periodontitis and oral disease are widespread with major and negative impacts on quality of life. Radiography is the standard of care in imaging but is limited to assessment of hard tissue. In the last three years, we have shown that ultrasound imaging offers significant advantages to oral health including non-invasive and real- time assessment of the periodontal probing depths, cementoenamel junction, gingival thickness, gingival perfusion/hypoxia, and clinical attachment loss. However, further clinical work in this field is limited by the large size of the ultrasound transducers—they are simply too large to access the posterior teeth. While smaller transducers exist, they cannot operate at the high frequency (>40 MHz) needed to image the small feature sizes involved in oral health. Therefore, we have established a three-way academic-industrial partnership to refine and finalize these devices for oral health. Dr. Jokerst at UCSD serves as PI and pioneered the use of photoacoustic imaging in oral health. VisualSonics Corp. is our industrial partner—Dr. Jokerst’s preliminary data was collected on VisualSonics equipment, and this company has a 20-year track record in developing high-frequency transducers including recent 510k-approved systems for human use. The clinical partner is Dr. Casey Chen who is Chair of Periodontology at USC and who will validate the system with human subjects. Aim 1 of the work will build and validate a small hockey stick-style transducer. While this design is already common, hockey stick transducers above 20 MHz are not available. Aim 2 will integrate diode lasers into the system for photoacoustic imaging to complement ultrasound. Aim 3 will develop image-processing algorithms to automatically export metrics of oral health such as clinical attachment loss and probing depth. Such automated image-processing is critical to broad clinical acceptance. Aim 4 will validate this device in healthy and diseased human subjects with comparisons to clinical gold standards. The significance of this work is based on the widespread prevalence of periodontal disease and the remarkable new insight that acoustic imaging offers in diagnosis and treatment planning. The innovative outcomes include non-invasive charting, direct measurements of the cementoenamel junction, noninvasive biotyping, and 3D maps of inflammation near implants. The work is feasible because of the track record of all three partners as well as their history of collaboration. This is a good investment for NIH because there is no miniaturized and high-frequency (>40 MHz) ultrasound transducer available despite the dramatic improvement in spatial resolution that high frequency offers. The proposal offers deliverables at all ranges of risk and the ultrasound transducer is highly likely to succeed with implications well beyond oral health: Applications in endoscopy, head and neck diseases, as well as transrectal/transvaginal imaging are obvious.

项目总结