A Miniaturized and High-frequency Acoustic Imaging System for Oral Health and Diseases of the Head and Neck

用于口腔健康和头颈疾病的小型化高频声学成像系统

• 批准号: 10650288
• 负责人: Jesse Vincent Jokerst
• 金额: $ 63.37万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-21 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650288
• 关键词: 3-Dimensional; 3D Print; Algorithms; American; Bicuspid; Cadaver; California; Canis familiaris; Cardiovascular Diseases; Clinical; Clinical assessments; Collaborations; Complement; Consumption; Data; Dental; Dental Care; Dental Enamel; Dental General Practice; Dentists; Devices; Diagnosis; Dimensions; Disease; Dose; Endoscopic Ultrasonography; Endoscopy; Equipment; Family suidae; Frequencies; Funding; Gingiva; Goals; Gold; Head and neck structure; Health; Health Professional; Hockey; Housing; Human; Hypoxia; Image; Imaging Device; Imaging technology; Implant; Incisor; Industrialization; Inflammation; Investments; Ionizing radiation; Jaw; Lasers; Lateral; Letters; Licensing; Light; Malignant Neoplasms; Maps; Measurement; Measures; Methods; Modality; Monitor; Mouth Diseases; Neck Disorder; Needles; Operative Surgical Procedures; Oral cavity; Oral health; Outcome; Pain; Patients; Performance; Perfusion; Periodontal Diseases; Periodontitis; Periodontium; Physiologic pulse; Prevalence; Process; Provider; Quality of life; Recording of previous events; Rectum; Resolution; Risk; Source; Surface; System; Technology; Thick; Time; Tissues; Tooth Cervix; Tooth Loss; Tooth structure; Transducers; Translating; Ultrasonic Transducer; Ultrasonography; United States National Institutes of Health; Universities; Vagina; Validation; Variant; Widespread Disease; Work; acoustic imaging; alveolar bone; biotypes; bone; clinical translation; commercialization; design; human data; human disease; human subject; image processing; imaging approach; imaging system; improved; in vivo imaging system; industry partner; innovation; insight; meter; miniaturize; miniaturized device; non-invasive imaging; photoacoustic imaging; radiological imaging; rectal; soft tissue; standard of care; technology validation; tool; treatment planning; ultrasound

PROJECT SUMMARY Periodontitis and oral disease are widespread with major and negative impacts on quality of life. Radiography is the standard of care in imaging but is limited to assessment of hard tissue. In the last three years, we have shown that ultrasound imaging offers significant advantages to oral health including non-invasive and real- time assessment of the periodontal probing depths, cementoenamel junction, gingival thickness, gingival perfusion/hypoxia, and clinical attachment loss. However, further clinical work in this field is limited by the large size of the ultrasound transducers—they are simply too large to access the posterior teeth. While smaller transducers exist, they cannot operate at the high frequency (>40 MHz) needed to image the small feature sizes involved in oral health. Therefore, we have established a three-way academic-industrial partnership to refine and finalize these devices for oral health. Dr. Jokerst at UCSD serves as PI and pioneered the use of photoacoustic imaging in oral health. VisualSonics Corp. is our industrial partner—Dr. Jokerst’s preliminary data was collected on VisualSonics equipment, and this company has a 20-year track record in developing high-frequency transducers including recent 510k-approved systems for human use. The clinical partner is Dr. Casey Chen who is Chair of Periodontology at USC and who will validate the system with human subjects. Aim 1 of the work will build and validate a small hockey stick-style transducer. While this design is already common, hockey stick transducers above 20 MHz are not available. Aim 2 will integrate diode lasers into the system for photoacoustic imaging to complement ultrasound. Aim 3 will develop image-processing algorithms to automatically export metrics of oral health such as clinical attachment loss and probing depth. Such automated image-processing is critical to broad clinical acceptance. Aim 4 will validate this device in healthy and diseased human subjects with comparisons to clinical gold standards. The significance of this work is based on the widespread prevalence of periodontal disease and the remarkable new insight that acoustic imaging offers in diagnosis and treatment planning. The innovative outcomes include non-invasive charting, direct measurements of the cementoenamel junction, noninvasive biotyping, and 3D maps of inflammation near implants. The work is feasible because of the track record of all three partners as well as their history of collaboration. This is a good investment for NIH because there is no miniaturized and high-frequency (>40 MHz) ultrasound transducer available despite the dramatic improvement in spatial resolution that high frequency offers. The proposal offers deliverables at all ranges of risk and the ultrasound transducer is highly likely to succeed with implications well beyond oral health: Applications in endoscopy, head and neck diseases, as well as transrectal/transvaginal imaging are obvious.

项目摘要 牙周炎和口腔疾病普遍存在，对生活质量产生重大负面影响。射线照相 是成像中的护理标准，但仅限于硬组织的评估。在过去的三年里， 显示超声成像为口腔健康提供了显着的优势，包括非侵入性和真实的- 牙周探诊深度、牙骨质-牙釉质交界处、牙龈厚度、牙龈厚度、 灌注/缺氧和临床附着丧失。然而，该领域的进一步临床工作受到以下因素的限制： 超声波传感器的尺寸太大-它们太大而不能进入后牙。而较小 换能器存在，它们不能在成像小特征所需的高频（>40 MHz）下工作 口腔健康的大小。因此，我们建立了三方学术和工业伙伴关系， 完善和完成这些口腔健康设备。加州大学圣地亚哥分校的Jokerst博士担任PI，并率先使用 光声成像在口腔健康中的应用VisualSonics公司是我们的工业合作伙伴-Jokerst博士的初步 数据是在VisualSonics设备上收集的，这家公司在开发 高频换能器，包括最近510 k批准的人类使用系统。临床合作伙伴是 博士南加州大学牙周病学主席凯西·陈将在人类受试者中验证该系统。 目标1的工作将建立和验证一个小型曲棍球棒式传感器。虽然这个设计已经 没有20 MHz以上的曲棍球棒传感器。Aim 2将把二极管激光器集成到 用于光声成像以补充超声的系统。AIM 3将开发图像处理算法 以自动导出口腔健康的度量，例如临床附着丧失和探测深度。等 自动图像处理对于广泛的临床接受是至关重要的。目标4将在健康情况下确认该器械 和患病的人类受试者与临床金标准进行比较。这项工作的意义在于 基于牙周病的广泛流行以及声学 成像在诊断和治疗计划中的作用。创新成果包括非侵入性制图， 直接测量牙骨质-牙釉质连接、非侵入性生物分型和炎症的3D图 靠近植入物。这项工作是可行的，因为所有三个伙伴的业绩记录以及他们的历史， 协作这对NIH来说是一项很好的投资，因为没有小型化和高频（>40 MHz）的超声换能器，尽管在空间分辨率上有显著的改进， 频率报价该提案提供了所有风险范围内的可交付成果，并且超声换能器高度 可能成功的影响远远超出口腔健康：在内窥镜检查，头部和颈部的应用 疾病，以及经直肠/经阴道成像是显而易见的。