DEVELOPMENT AND REGENERATION OF NERVES

神经的发育和再生

• 批准号: 3394149
• 负责人: RICHARD E COGGESHALL
• 金额: $ 11.7万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-01-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3394149
• 关键词: afferent nerve; axon; cell death; dorsal root; laboratory rat; myelination; nervous system regeneration; neuroanatomy; neurogenesis; neurosurgery; neurotrophic factors; peripheral nervous system; silicon; spinal ganglion

The basic goals of this proposal are to show 1) there is a considerable postnatal decline in dorsal root and peripheral axon numbers that is not associated with death of the sensory cells that give rise to these axons, 2) that putting stumps of a transected nerve in a silicone tube protects those sensory cells that would normally die because of the transection. The common thread linking these 2 ideas is that they are both the results of competition for growth factors, and the most likely candidate is nerve growth factor. Experimental surgery will be used to produce the lesions and the data consist of numbers of sensory cells, myelinated and unmyelinated axons and blood vessels and the structure of the perineurium. If these goals can be met, very important health related goals will be achieved. First, our data would show that a loss of axons not caused by death of cells is a relatively general event in mammalian neural development. Second if placing nerve stumps in silicone tubes keeps dorsal root ganglion cells from dying, this would provide a rational reason for using such tubes in therapy.

本提案的基本目标是：（1） 背根和外周轴突在出生后明显衰退 与感觉细胞死亡无关的数字， 产生了这些轴突，2）将横断的树桩 硅胶管中的神经保护那些感觉细胞 通常会因为横切而死亡 普通螺纹连接 这两个想法都是竞争的结果 生长因子，最有可能的候选者是神经生长 因子 实验性手术将用于产生病变 数据包括感觉细胞的数量，有髓鞘的， 无髓轴突和血管以及 神经束膜 如果这些目标能够实现，非常重要的健康 相关目标将会实现。 首先，我们的数据显示， 不是由细胞死亡引起的轴突损失是一种相对 哺乳动物神经发育的一般事件。 第二，如果放置 硅胶管中的神经残端保持背根神经节细胞 死亡，这将提供一个合理的理由，使用这种 在治疗中插管子