DEVELOPMENT AND REGENERATION OF NERVES

这项提案的基本目标是表明1)有一个 出生后背根和外周轴突的显著下降 与感官细胞死亡无关的数字 产生这些轴突，2)把横断的残肢 硅胶管中的神经保护那些 通常会因为横切而死亡。共同的主线 将这两个想法联系在一起是它们都是 对增长因素的竞争，最有可能的候选人是 神经生长因子。实验性手术将被用来 产生损伤，数据由感官的数量组成 细胞，有髓和无髓轴突和血管 神经外膜的结构。如果这些目标能够实现，非常 将实现与健康相关的重要目标。首先，我们的数据 将表明，不是由细胞死亡引起的轴突损失是一种 哺乳动物神经发育中相对普遍的事件。 第二，如果将神经残端放置在硅胶管中保持背根 神经节细胞的死亡，这将为 在治疗中使用这种管子。

The basic goals of this proposal are to show 1) there is a considerable postnatal decline in dorsal root and peripheral axon numbers that is not associated with death of the sensory cells that give rise to these axons, 2) that putting stumps of a transected nerve in a silicone tube protects those sensory cells that would normally die because of the transection. The common thread linking these 2 ideas is that they are both the results of competition for growth factors, and the most likely candidate is nerve growth factor. Experimental surgery will be used to produce the lesions and the data consist of numbers of sensory cells, myelinated and unmyelinated axons and blood vessels and the structure of the perineurium. If these goals can be met, very important health related goals will be achieved. First, our data would show that a loss of axons not caused by death of cells is a relatively general event in mammalian neural development. Second, if placing nerve stumps in silicone tubes keeps dorsal root ganglion cells from dying, this would provide a rational reason for using such tubes in therapy.