DEVELOPMENT AND REGENERATION OF NERVES

神经的发育和再生

• 批准号: 3394146
• 负责人: RICHARD E COGGESHALL
• 金额: $ 11.83万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-01-01 至 1991-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3394146
• 关键词: axon; dorsal root; electron microscopy; histology; motor neurons; myelination; nervous system regeneration; neural information processing; neuroanatomy; neurotrophic factors; peripheral nervous system; spinal ganglion; sympathetic nervous system; ventral roots; visceral afferent nerve

The basic goals of this proposal are to show 1) there is a considerable postnatal decline in dorsal root and peripheral axon numbers that is not associated with death of the sensory cells that give rise to these axons, 2) that putting stumps of a transected nerve in a silicone tube protects those sensory cells that would normally die because of the transection. The common thread linking these 2 ideas is that they are both the results of competition for growth factors, and the most likely candidate is nerve growth factor. Experimental surgery will be used to produce the lesions and the data consist of numbers of sensory cells, myelinated and unmyelinated axons and blood vessels and the structure of the perineurium. If these goals can be met, very important health related goals will be achieved. First, our data would show that a loss of axons not caused by death of cells is a relatively general event in mammalian neural development. Second, if placing nerve stumps in silicone tubes keeps dorsal root ganglion cells from dying, this would provide a rational reason for using such tubes in therapy.

本提案的基本目标是：（1） 背根和外周轴突在出生后明显衰退 与感觉细胞死亡无关的数字， 产生了这些轴突，2）将横断的树桩 硅胶管中的神经保护那些感觉细胞 通常会因为横切而死亡 的共同点 把这两个想法联系起来的原因是，它们都是 竞争生长因子，最有可能的候选人是 神经生长因子。 实验性手术将用于 产生病变，数据由许多感觉 细胞、有髓和无髓轴突和血管， 神经束膜的结构 如果这些目标能够实现， 将实现与健康有关的重要目标。 首先，我们的数据 将表明，轴突的损失不是由细胞死亡引起的， 哺乳动物神经发育中相对普遍的事件。 第二，如果把神经残端放在硅胶管里 神经节细胞死亡，这将提供一个合理的理由， 在治疗中使用这种管子。