OPTICAL STUDIES OF NEURON ACTIVITY AND ORGANIZATION
OPTICAL STUDIES OF NEURON ACTIVITY AND ORGANIZATION
批准号:
3393770
负责人:
LAWRENCE B COHEN
金额:
$22.25万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1977
资助国家:
美国
项目状态:
已结题
起止时间:
1977-02-01 至 1988-01-31
关键词:
action potentials electroencephalography electrophysiology fresh water environment ganglions hippocampus imaging /visualization /scanning limbic system membrane potentials monitoring device neural information processing neuroanatomy neurons neurophysiology olfactions olfactory lobe psychobiology sensory mechanism somesthetic sensory cortex stimulus /response visual cortex visual pathways visual stimulus
中文摘要
这个项目的所有目标都涉及到光学方法的使用
英文摘要
All of the objectives of this project involve the use of optical methods
for monitoring neuron activity. These methods are based on the finding
that certain dyes, when bound to membranes, change their optical properties
in response to changes in membrane potential.
In invertebrate ganglia optical monitoring detects the individual
action-potentials in individual cell bodies. Using a 124 element
photodiode array positioned in a microscope image plane we have been able
to monitor the activity of many neurons of Aplysia or Pleurobranchaea
buccal ganglia. We think we are approaching the capability of monitoring
most of the spike activity in such preparations. This would provide a
powerful tool for determining all of the neurons active during particular
behaviors and for testing hypothese about neuronal control of simple
behaviours. We are particularly interested in the nuronal basis of simple
forms of learning. Additional behavioral experiments and optical
measurements in semi-intact preparations are proposed for the immediate
future. These would be followed by attempts to determine how the
interactions between neurons changed to accomplish the behavior.
In vertebrate nervous systems optical monitoring does not yet have single
cell resolution. The signals represent average changes in membrane
potential of the neurons and processes imaged onto the individual
detectors. At present it is possible to measure changes in activity in rat
sensory cortex in response to whisker movement or light flashes. We plan
experiments to improve the signal-to-noise ratio in these experiments, to
develop the use of optical measurements in cat visual cortex, and to
determine if there is odor dependent localization of activity in the
salamander olfactory bulb.
Neurosurgeons could more accurately locate primary epileptogenic areas of
cortex if they could identify epileptic foci in the inter-siezure
interval. Since neurons in the epileptic foci are said to be somewhat
depolarized during the intersiezure interval, voltage sensitive dyes might
be used to locate these cells. We plan experiments on model systems to
test the feasibility of two possible approaches toward localization.
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New approaches for better protein voltage sensors
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批准号:9231604
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项目类别:
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资助金额:$72.67万
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财政年份:2016
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依托单位:
New approaches for better protein voltage sensors
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批准号:9358357
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项目类别:
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资助金额:$69.29万
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财政年份:2016
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Scan of Protein Space for Optical Voltage Probes
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批准号:8337047
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项目类别:
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资助金额:$2.0万
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财政年份:2007
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负责人:LAWRENCE B COHEN
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依托单位:
Scan of Protein Space for Optical Voltage Probes
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批准号:7492061
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资助金额:$98.09万
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财政年份:2007
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Scan of Protein Space for Optical Voltage Probes
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批准号:7912355
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项目类别:
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资助金额:$24.02万
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财政年份:2007
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负责人:LAWRENCE B COHEN
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依托单位:
Scan of Protein Space for Optical Voltage Probes
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批准号:7926907
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项目类别:
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资助金额:$97.53万
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财政年份:2007
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负责人:LAWRENCE B COHEN
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依托单位:
Scan of Protein Space for Optical Voltage Probes
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批准号:7317193
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项目类别:
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资助金额:$102.24万
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财政年份:2007
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负责人:LAWRENCE B COHEN
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依托单位:
Scan of Protein Space for Optical Voltage Probes
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批准号:7683164
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项目类别:
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资助金额:$96.8万
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财政年份:2007
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负责人:LAWRENCE B COHEN
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依托单位:
Scan of Protein Space for Optical Voltage Probes
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批准号:8133686
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项目类别:
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资助金额:$98.54万
-
财政年份:2007
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负责人:LAWRENCE B COHEN
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依托单位:
OPTICAL RECORDING OF SYNAPTIC POTENTIAL INTEGRATION
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批准号:3414957
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项目类别:
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资助金额:$6.1万
-
财政年份:1990
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负责人:LAWRENCE B COHEN
-
依托单位:
OPTICAL RECORDING OF SYNAPTIC POTENTIAL INTEGRATION
-
批准号:3414956
-
项目类别:
-
资助金额:$6.17万
-
财政年份:1990
-
负责人:LAWRENCE B COHEN
-
依托单位:
OPTICAL RECORDING OF SYNAPTIC POTENTIAL INTEGRATION
-
批准号:3414954
-
项目类别:
-
资助金额:$6.44万
-
财政年份:1990
-
负责人:LAWRENCE B COHEN
-
依托单位:
MOLECULAR AND CELLULAR NEUROBIOLOGY
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批准号:2260293
-
项目类别:
-
资助金额:$13.1万
-
财政年份:1977
-
负责人:LAWRENCE B COHEN
-
依托单位:
MOLECULAR AND CELLULAR NEUROBIOLOGY
-
批准号:3543612
-
项目类别:
-
资助金额:$10.87万
-
财政年份:1977
-
负责人:LAWRENCE B COHEN
-
依托单位:
Optical Studies of Neuron Activity and Organization
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批准号:6439715
-
项目类别:
-
资助金额:$39.04万
-
财政年份:1977
-
负责人:LAWRENCE B COHEN
-
依托单位:
OPTICAL STUDIES OF NEURON ACTIVITY AND ORGANIZATION
-
批准号:6323759
-
项目类别:
-
资助金额:$5.0万
-
财政年份:1977
-
负责人:LAWRENCE B COHEN
-
依托单位:
MOLECULAR AND CELLULAR NEUROBIOLOGY
-
批准号:3543613
-
项目类别:
-
资助金额:$11.81万
-
财政年份:1977
-
负责人:LAWRENCE B COHEN
-
依托单位:
OPTICAL STUDIES OF NEURON ACTIVITY & ORGANIZATION
-
批准号:3393774
-
项目类别:
-
资助金额:$33.78万
-
财政年份:1977
-
负责人:LAWRENCE B COHEN
-
依托单位:
OPTICAL STUDIES OF NEURON ACTIVITY & ORGANIZATION
-
批准号:3393767
-
项目类别:
-
资助金额:$27.36万
-
财政年份:1977
-
负责人:LAWRENCE B COHEN
-
依托单位:
OPTICAL STUDIES OF NEURON ACTIVITY & ORGANIZATION
-
批准号:3393775
-
项目类别:
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资助金额:$38.93万
-
财政年份:1977
-
负责人:LAWRENCE B COHEN
-
依托单位:
海外基金