INFERIOR COLLICULUS NEURONS: PHYSIOLOGY AND ANATOMY

这项研究的目的是研究潜在的神经机制， 猫下丘的双耳信号处理。 该提案 解决了三个问题：1）高频神经元 利用耳间时间线索; 2）突触之间的关系 组织和双耳处理;和3）下降的作用 皮质输入对双耳响应特性的影响。 高频 这些研究可能为观察到人类 听众可以根据以下因素来偏侧复杂的高频信号： 耳间时间线索;这一发现需要修改的 经典观点认为低频和高频系统使用分开 定位线索：耳间时间和耳间强度线索， 分别 突触组织研究的目的是 确定负责双耳交互的神经机制，以及 相关的超微结构成分。 审查的理由 皮质影响是发现来自同侧的传入神经 听觉皮层投射到一个特定的和分区的实质性的细分 也就是背侧皮质 自降 皮质和上行丘系输入在这个细分中是混合的， 双耳的相互作用可能不同于中央核; 下丘只接受丘系输入的部分。 到 为了解决上述问题，我们将采用细胞外和细胞内 录音、声刺激和电刺激，以及光和电子 微观分析

The goal of this research is to study the neural mechanisms underlying binaural signal processing in the cat inferior colliculus. The proposal addresses three issues: 1) the mechanism by which high frequency neurons utilize interaural time cues; 2) the relationship between synaptic organization and binaural processing; and 3) the role of descending cortical inputs on binaural response properties. The high frequency studies may provide the neural basis for the observation that human listeners can lateralize complex high frequency signals on the basis of interaural time cues; a finding that has necessitated modification of the classic view that the low and high frequency system use separate localization cues: interaural time and interaural intesity cues, respectively. The purpose of the synaptic organization studies is to determine the neural mechanisms responsible for binaural interactions, and the related ultrastructural components. The rationale of examining cortical influences is the finding that afferents from the ipsilateral auditory cortex project to a specific and division substantial subdivision of the inferior colliculus, viz. the dorsal cortex. Since descending cortical and ascending lemniscal inputs are mixed in this subdivision, the binaural interactions may be different from that in the central nucleus; a division of the inferior colliculus that only receives lemniscal input. To resolve the above issues, we will employ extra and intracellular recordings, acoustical and electrical stimulation, and light and electron microscopic analysis.