Sensorimotor processing of auditory feedback in aphasia

失语症听觉反馈的感觉运动处理

• 批准号: 10201559
• 负责人: Roozbeh Behroozmand
• 金额: $ 13.87万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-05 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201559
• 关键词: Aphasia; Area; Associative aphasia; Auditory; Behavioral; Biological Markers; Brain; Brain Injuries; Communication; Comprehension; Control Groups; Data; Detection; Development Plans; Diagnosis; Effectiveness; Environment; Family; Feedback; Foundations; Goals; Health Care Costs; Human; Impairment; Individual; Knowledge; Lead; Left; Lesion; Measures; Mentors; Methodology; Mission; Modeling; Monitor; Motor; National Institute of Neurological Disorders and Stroke; Outcome; Outcome Measure; Patients; Pattern; Play; Production; Public Health; Quality of life; Recovery; Research; Research Personnel; Research Training; Role; Signal Transduction; Source; Speech; Speech Disorders; Stroke; Structure; Symptoms; System; Therapeutic Intervention; Translating; Translational Research; Translations; United States; United States National Institutes of Health; auditory feedback; auditory processing; base; behavioral study; career development; connectome; disability; improved; indexing; motor control; neuroimaging; neurological rehabilitation; novel; post stroke; preservation; relating to nervous system; response; sensory feedback; social; speech processing; stroke patient; stroke-induced aphasia; targeted treatment; tractography; treatment strategy; white matter damage

PROJECT SUMMARY/ABSTRACT Stroke is a leading cause of disability in the United States, which in many cases can lead to speech impairment that creates barriers to participation in professional, social, and family settings. Aphasia is the most common type of post-stroke speech impairment that has profound consequences for the patients and results in diminished ability to comprehend, produce and control speech. While recovery can be promoted with speech treatment, improvement remains modest and typically requires a large amount of therapy which contributes to rising health care costs. A major shortcoming of currently existing treatment approaches is that they have focused on enhancing the outcome measures associated speech production, without taking into account that targeting deficits in sensory feedback processing of speech may significantly increase treatment efficiency and effectiveness. Therefore, a key step toward refining treatment strategies is to develop objective biomarkers that can probe the integrity of sensorimotor mechanisms of speech and identify their impaired function in patients with post-stroke aphasia. This proposed project is significant because it takes the first step toward exploring the behavioral and neuroanatomical biomarkers of impaired sensorimotor processing, with focus on understanding the critical role of auditory feedback mechanisms for speech production in aphasia. The career development plan combines the candidate's former research training with expertise of the mentoring team to meet the goals of the proposed project. The research and training plans provide an empirical foundation for the proposed project and will allow the candidate to establish a translational line of research as an independent investigator to study the behavioral and neural bases of speech sensorimotor impairment in stroke patients with aphasia. This project aims to use the behavioral biomarkers of altered auditory feedback (AAF) combined with neuroimaging data to identify the patterns of brain damage and diminished structural connectivity within the auditory-motor areas of the left hemisphere that predict impaired sensorimotor processing of speech in aphasia. The long-term goal of this research is to develop a model that relates patterns of brain damage to sensorimotor deficits causing speech impairment. The main objective of this proposal is to identify behavioral and neuroanatomical biomarkers that characterize deficits in sensorimotor mechanisms of speech. The central hypothesis is that damages to auditory-motor network will impair speakers' ability to detect and/or correct for AAF-induced speech errors. We also hypothesize that the patterns of damage will predict the degree of diminished speech error processing, as indexed by the AAF biomarkers. The rationale for the proposed research is that identifying the source of sensorimotor deficit will improve diagnosis and targeted treatment of speech disorders in aphasia. The proposed research is relevant to that part of NIH's mission that pertains to developing fundamental knowledge that will potentially help to reduce the burdens of human disability.

项目摘要/摘要 在美国，中风是导致残疾的主要原因，在许多情况下，中风会导致言语障碍 这造成了参与专业、社会和家庭环境的障碍。失语症是最常见的 中风后言语障碍的类型，对患者有深远的后果，并导致 理解、产生和控制语言的能力减弱。虽然语言可以促进恢复 治疗，改善仍然不大，通常需要大量的治疗，这有助于 不断上涨的医疗保健成本。目前现有的治疗方法的一个主要缺点是它们具有 侧重于加强与演讲产出相关的成果衡量标准，但没有考虑到 针对语音感觉反馈处理的缺陷可以显著提高治疗效率和 有效性。因此，完善治疗策略的关键一步是开发客观的生物标记物 可以探测患者言语感觉运动机制的完整性，并识别其功能受损 中风后失语症。这个拟议的项目意义重大，因为它迈出了探索的第一步 感觉运动加工受损的行为和神经解剖学生物标志物，重点是 了解失语症患者听觉反馈机制对言语产生的关键作用。职业生涯 发展计划将候选人以前的研究培训与指导团队的专业知识相结合，以 达到拟议项目的目标。研究和培训计划为以下工作提供了经验基础 提议的项目，并将允许候选人建立一个翻译研究作为一个独立的 研究人员研究中风患者言语感觉运动障碍的行为和神经基础 患有失语症。该项目旨在联合使用改变的听觉反馈(AAF)的行为生物标记物 通过神经成像数据来识别脑损伤的模式和脑内结构连接性减弱 左侧大脑半球听觉运动区预测语言感觉-运动加工受损 失语症。这项研究的长期目标是开发一种模型，将脑损伤的模式与 感觉运动缺陷导致言语障碍。该提案的主要目标是确定行为 以及神经解剖学生物标记物，它们表征了言语感觉运动机制的缺陷。中环 假说是，听觉-运动网络的损害将削弱说话者检测和/或纠正 AAF诱发的言语错误。我们还假设，损坏的模式将预测 减少了语音错误处理，由AAF生物标记物标示。建议的理由是 研究表明，找出感觉运动缺陷的来源将提高诊断和针对性治疗 失语症中的言语障碍。这项拟议的研究与美国国立卫生研究院任务中与以下有关的部分相关 发展可能有助于减轻人类残疾负担的基础知识。