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An Investigation of Multicomponent Azole Chemistry within a Generational System for the Expression the Canonical Genetic Structures

代系系统内多组分唑化学的研究，用于表达典型的遗传结构

基本信息

批准号：
EP/K004980/1
负责人：
Matthew Powner
金额：
$ 123.66万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FK004980%2F1
关键词：
Investigation Multicomponent Azole Chemistry within

项目摘要

The underlying biochemical unity of life suggests a chemical origin of life, indeed organic chemistry arose from the desire to synthesise, characterise and understand the chemical constituents of life, and natural products and biocatalysts are benchmarks for what can be achieved in organic chemistry. Despite the scientific advances of the intervening two centuries, discovering the chemical transformations that initiated life represents one of the most important, fundamental and challenging chemical questions being addressed by modern science.There are three classes of macromolecules that are absolutely necessary for all extant life-DNA, RNA and proteins. We seek to experimentally establish a link between the generational requirements of both classes of nucleic acid and proteins. A systems chemistry research programme will be implemented to elucidate corroborative chemical pathways to understand the generational relationship and commonality of the key constituent molecules of DNA, RNA and proteins.The work proposed in this fellowship is designed to advance the undeveloped potential of both organosulfur chemistry and multicomponent reactivity in abiogenesis. Within the overall context of organic chemistry and, more specifically, origins of life research, the potential of multicomponent reactions has certainly been recognized as a key element for rapid and succinct build-up of molecular complexity. In contrast to the vast majority of multicomponent reactions, which feature an isonitrile as the key component, the work outlined in this proposal features azoles as an essential element for multicomponent reactivity. New three- and four-component reactivity will be developed. Furthermore, the reactivity of sulfur will be exploited to access new reactivity motifs, allowing unexplored chemistry and chemical pathways to be discovered. Throughout the course of this fellowship new green chemical reactivity and multicomponent reactions will be discovered. We will continue to develop systems chemistry to broaden and deepen the understanding of how systems chemistry can be used to access commercially important products and, significantly, the generational relationship of the constituent macromolecules of biology as the products of one chemical system.

生命潜在的生物化学统一性表明了生命的化学起源，事实上，有机化学源于对合成、表征和理解生命化学成分的渴望，天然产物和生物催化剂是有机化学所能取得成就的基准。尽管在过去的两个世纪里科学取得了进步，但发现生命起源的化学转化仍然是现代科学正在解决的最重要、最基本和最具挑战性的化学问题之一。有三种大分子对所有现存的生命都是绝对必要的——dna、RNA和蛋白质。我们试图通过实验建立两类核酸和蛋白质的代际需求之间的联系。将实施一项系统化学研究方案，阐明确证的化学途径，以了解DNA、RNA和蛋白质的主要组成分子的代际关系和共性。本奖学金提出的工作旨在推进有机硫化学和多组分反应性在自然发生中的未开发潜力。在有机化学的整体背景下，更具体地说，在生命起源的研究中，多组分反应的潜力无疑被认为是快速而简洁地建立分子复杂性的关键因素。与绝大多数以异腈为关键组分的多组分反应相反，本提案中概述的工作将偶氮作为多组分反应性的基本元素。将开发新的三组分和四组分反应性。此外，硫的反应性将被利用来获得新的反应性基序，从而发现未被探索的化学和化学途径。在整个研究过程中，新的绿色化学反应性和多组分反应将被发现。我们将继续发展系统化学，以扩大和加深对系统化学如何用于获取商业上重要产品的理解，更重要的是，作为一个化学系统的产物，生物成分大分子的代际关系。