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BRAIN TRANSPLANTATION AND OLFACTORY NEURONS INTERACTION

BRAIN TRANSPLANTATION AND OLFACTORY NEURONS INTERACTION
脑移植和嗅觉神经元相互作用
批准号:
3401245
负责人:
PASQUALE P GRAZIADEI
金额:
$10.1万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-04-01 至 1987-03-31

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中文摘要
翻译
我们建议研究嗅觉感觉神经元之间的相互作用
英文摘要
We propose to study the interaction between the olfactory sensory neurons and the neuronal populations of the olfactory bulbar and cerebellar cortexes, by means of transplantation techniques. The two cortexes will be transplanted close to the intracranial side of the lamina cribrosa, to study their interaction with the olfactory sensory axons when the olfactory neurons are left in situ. Subsequently, the olfactory neurons (contained in fragments of olfactory mucosa), will be transplanted directly into the olfactory bulb and cerebellum of neonatal and adult rats to study their interaction with these cortexes when the latter are left in situ. In the third experiment both the olfactory neurons and the cortexes will be transplanted in the anterior chamber of the eye to study their interaction when both tissues are removed from their normal locations. Prelimininary studies have demonstrated that, when the olfactory neurons are transplanted away from the nasal cavity, they migrate away from the neuroepithelium and into the host's tissue. The destiny and the possible innteraction of the migrating olfactory neurons with the host's C.N.S. will be investigated. The proposed study will use histological techniques as well as ultrastructural, autoradiographic and immunohistochemical methods. The program proposes to define the inductive capacity of the olfactory neurons in a variety of experimental setting and to investigate their plasticity and migratory potential.
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FUNTIONAL MORPHOLOGY OF THE OLFACTORY BULB
  • 批准号:
    3217775
  • 项目类别:
  • 资助金额:
    $4.08万
  • 财政年份:
    1991
  • 负责人:
    PASQUALE P GRAZIADEI
  • 依托单位:
FUNTIONAL MORPHOLOGY OF THE OLFACTORY BULB
  • 批准号:
    2126222
  • 项目类别:
  • 资助金额:
    $4.4万
  • 财政年份:
    1991
  • 负责人:
    PASQUALE P GRAZIADEI
  • 依托单位:
FUNTIONAL MORPHOLOGY OF THE OLFACTORY BULB
  • 批准号:
    3217777
  • 项目类别:
  • 资助金额:
    $4.23万
  • 财政年份:
    1991
  • 负责人:
    PASQUALE P GRAZIADEI
  • 依托单位:
PHILIPS CM10 TRANSMISSION ELECTRON MICROSCOPE
  • 批准号:
    3519603
  • 项目类别:
  • 资助金额:
    $16.0万
  • 财政年份:
    1987
  • 负责人:
    PASQUALE P GRAZIADEI
  • 依托单位:
海外基金