HORMONAL AND EXPERIENTIAL EFFECTS ON BEHAVIOR

成年雄性对婴儿的暴力行为被认为发生在许多物种中， 但人们对影响经济增长的因素知之甚少。 成年雄性对幼年的行为。本文件中包含的实验 关于管制杀婴(杀害幼童)和 雄性家鼠(Mus Musculus)的亲子行为我最近发现 交配经验显著影响雄性小鼠对 年轻：交配后12至50天，大多数雄性表现得像父母一样 年轻的时候，而在这个时间之前和之后，大多数雄性 杀婴。这一发现的显著特点是，男性自身的 幼崽将在交配后19天出生，然后正常断奶约50天 交配后几天。因此，雄性小鼠的犯罪行为受到抑制 在交配后正好在它们可能在的时间内使用婴儿杀菌剂 与自己的后代接触。此前的实验表明， 交配本身，而不是承认一个单独的女性和她 年轻，引发了这些行为的变化。第一套建议 实验将提供有关以下相关刺激的信息 交配和参与调节这些变化的感觉通路 行为。此外，参与调解杀婴的大脑区域 父母的行为也将受到调查。最后，实验证明 确定垂体和/或性腺激素是否影响 交配后对幼鸟的行为将被进行。 第二组实验将包括检查发育的雄性小鼠 在两个男性胎儿(200万个男性)之间的宫内，一男一女之间 胎儿(100万男性)，以及两个女性胎儿之间(OM男性)。OM男性 胎儿在一生中接触到高滴度的雌二醇。 到200万男性胎儿，以及大多数性行为幼稚的成年OM男性 杀婴，而大多数性幼稚的成年200万男性表现得像父母一样 朝向年轻人(100万男性的行为介于OM和2M之间 男性)。OM、1M和2M雄性小鼠将通过剖腹产和 在成年前和成年后检查他们对年轻人的行为 交配。因此，这项实验将评估之前的宫内 职位限制了成人经历对行为的影响程度 在雄性小鼠中向年轻的方向发展。

Violence toward infants by adult males is thought to occur in many species, but relatively little is known about the factors which influence the behavior of adult males toward young. The experiments contained in this proposal concern the regulation of infanticide (the killing of young) and parental behavior in male house mice (Mus musculus). I recently found that experience mating markedly influences the behavior of male mice toward young: between 12 and 50 days after mating most males behave parentally toward young, while before and after this time most males commit infanticide. The striking feature of this finding is that a male's own young would be born 19 days after mating and then normally weaned bout 50 days after mating. Thus, male mice are inhibited from committing infancticide after mating exactly during the time that they could be in contact with their own offspring. Previous experiments have revealed that mating per se, rather than recognition of an individual female and her young, triggers these changes in behavior. The first set of proposed experiments will provide information concerning the stimuli associated with mating and the sensory pathways involved in mediating these changes in behavior. In addition, the brain areas involved in mediating infanticide and parental behavior will be investigated. Finally, experiments to determine whether pituitary and/or gonadal hormones influence changes in behavior toward young after mating will be conducted. The second set of experiments will involve examining male mice that develop in utero between two male fetuses (2M males), between a male and a female fetus (1M males), and between two female fetuses (OM males). OM male fetuses are exposed to high titers of estradiol during fetal life relative to 2M male fetuses, and most sexually-naive adult OM males commit infanticide while most sexually-naive adult 2M males behave parentally toward young (1M males are intermediate in behavior between OM and 2M males). OM, 1M and 2M male mice will be delivered by Cesarean section and examined in adulthood for their behavior toward young both before and after mating. This experiment will thus assess whether prior intrauterine position limits the degree to which adult experience can influence behavior toward young in male mice.