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Fully-Integrated Continuous Flow Processes for Access to Forbidden Chemistries, New Reactivities and Sequential Complexity Generation

用于获取禁用化学物质、新反应性和顺序复杂性生成的完全集成的连续流程

基本信息

批准号：
EP/K009494/1
负责人：
Steven Ley
金额：
$ 326.09万
依托单位：
University of Cambridge
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FK009494%2F1
关键词：
Fully Integrated Continuous Flow Processes

项目摘要

Sustainability and greatly improved chemical processes are driving the pace of change in chemical synthesis. As a community, we need to discover new reactions and new types of chemical reactivity that are cleaner and deliver new materials with desired functions. Furthermore, we need to substantially enhance the tools of the synthesis processes we use and move towards an integrated machine-assisted approach that will allow us to capture the most useful and emerging hardware devices and software developments. This required a radical change in our approach to molecule synthesis. By moving away from traditional batch mode operations for the synthesis of molecules to continuous flow processing many benefits can be gained and these lead to improved safety, lower solvent use and less waste. Our proposed research will demonstrate an approach that will address these needs directly as it focuses on advancing flow reactor technology and harnessing their unique features to solve contemporary chemistry problems. Using continuous flow reactor platforms we will make discoveries in new areas of chemistry following more sustainable and environmentally acceptable sequences leading to new products with wide ranging functional properties particularly useful for the healthcare marketplace. To do this we will also devise new machinery that will facilitate extended working regimes and will release talented individuals from routine scale-up and optimisation tasks. These concepts will lead to a cultural change in the current practice of molecular construction. In doing this, the work will have a long-term impact well beyond the initial research programme. The outcomes from this research should provide access to new types of material not possible from previous conventional approaches and could open up biomimetic pathways for further exploitation leading to new complexity generation methods.

可持续性和化学工艺的极大改进正在推动化学合成的变革步伐。作为一个社区，我们需要发现新的反应和新类型的化学反应，这些反应和化学反应更清洁，并提供具有所需功能的新材料。此外，我们需要大大增强我们使用的合成过程的工具，并转向集成的机器辅助方法，这将使我们能够捕获最有用的和新兴的硬件设备和软件开发。这需要我们对分子合成方法进行彻底的改变。通过从用于合成分子的传统分批模式操作转移到连续流动处理，可以获得许多益处，并且这些益处导致改进的安全性、更低的溶剂使用和更少的浪费。我们提出的研究将展示一种直接解决这些需求的方法，因为它专注于推进流动反应器技术，并利用其独特的功能来解决当代化学问题。使用连续流反应器平台，我们将在新的化学领域进行探索，遵循更可持续和环境可接受的顺序，从而产生具有广泛功能特性的新产品，特别是对医疗保健市场有用的产品。为此，我们还将设计新的机制，以促进扩展工作制度，并将有才华的个人从常规的规模扩大和优化任务中解放出来。这些概念将导致当前分子构建实践中的文化变革。在这样做的过程中，这项工作将产生远远超出最初研究方案的长期影响。这项研究的结果应该提供了从以前的传统方法中无法获得的新型材料，并可以开辟仿生途径，以进一步开发新的复杂性生成方法。