A Synthesis Programme at Cambridge

本提案中提出的研究包括广泛的具有挑战性的项目。全合成将需要发展现有的反应和发明新的方法。我们将开发新的合成方法和分子合成的新工具。本文件中提出的综合科学计划有许多值得赞扬的地方。对更有效合成的渴望刺激了新反应性的发现以解决特定问题。新的反应可以为全合成和类似物生成开辟以前无法进入的领域。这些驱动因素影响着新的合成方法的开发。具有一个紧密结合的方案，其中包括开发新的合成方法，进行反应和全合成的新方法，所产生的附加值是相当大的。所有这些学科都将推动创造性的过程。这无疑是一个巨大的挑战，但我们认为值得投资。

The research presented in this proposal, encompasses a broad range of challenging projects. The total syntheses will require the development of existing reactions and the invention of new processes. We will develop new synthetic methods and new tools for molecular synthesis. There is much to commend an integrated programme of science as presented in this document. The desire for more efficient syntheses stimulates the discovery of new reactivities to solve particular problems. New reactions can open up areas for total synthesis and analogue generation that were previously inaccessible. These drivers impact on the development of new methods for synthesis. The added value that arises from having a closely coupled programme containing the development of new synthetic methods, new ways of performing reactions and total synthesis is considerable. All these disciplines will drive the creative process. It is undoubtedly a grand challenge, but one we feel is worthy of investment.