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CONTROL OF NEURON POPULATION SIZE IN POLYPLOID ANURANS

CONTROL OF NEURON POPULATION SIZE IN POLYPLOID ANURANS
多倍体无尾动物神经元数量的控制
批准号:
3403565
负责人:
DAVID G SPERRY
金额:
$5.72万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-04-01 至 1988-07-31

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中文摘要
翻译
关于神经元精确发育调控的主流解释
英文摘要
The prevailing explanation for precise developmental regulation of neuron numbers is that neurons and postsynaptic targets are size matched by a process involving competition and neuronal cell death. Xeonpus laevis of different ploidy have the same body size, but differ in neuron size and number. These differences provide a way to test whether cell death matches neuron numbers to peripheral size. An alternate possibility, that total neuronal volume rather than neuron number is matched to peripheral size, will also be tested. Lumbar motor and sensory neuron population sizes (cell numbers and neuronal nuclear size) will be measured and compared with limb size (surface area, volume, and muscle fiber number). The measurements will be made for normally developing diploids, triploids and tetraploids at stages before, during, and after cell death, and show whether there is any correlation between either neuron number or total neuron volume and some measure of peripheral size. Additionally, hindlimb buds at an early developmental stage will be transplanted between donors and hosts of different ploidy. Measuring neuron populations that develop in the hosts will show whether limbs have intrinsic qualities that regulate cell death to produce neuron populations of appropriate numbers. This information is relevant to understanding how similarities and differences in neuron population size result from normal or abnormal development.
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CONTROL OF NEURON POPULATION SIZE IN POLYPLOID ANURANS
  • 批准号:
    3403564
  • 项目类别:
  • 资助金额:
    $5.94万
  • 财政年份:
    1985
  • 负责人:
    DAVID G SPERRY
  • 依托单位:
CONTROL OF NEURON POPULATION SIZE
  • 批准号:
    3403567
  • 项目类别:
  • 资助金额:
    $9.85万
  • 财政年份:
    1985
  • 负责人:
    DAVID G SPERRY
  • 依托单位:
CONTROL OF NEURON POPULATION SIZE IN POLYPLOID ANURANS
  • 批准号:
    3403561
  • 项目类别:
  • 资助金额:
    $7.88万
  • 财政年份:
    1985
  • 负责人:
    DAVID G SPERRY
  • 依托单位:
CONTROL OF NEURON POPULATION SIZE
  • 批准号:
    3403563
  • 项目类别:
  • 资助金额:
    $10.13万
  • 财政年份:
    1985
  • 负责人:
    DAVID G SPERRY
  • 依托单位:
国内基金
海外基金
炎性反应中巨噬细胞激活诱导死亡(activation-induced cell death,AICD)的机理研究
  • 批准号:
    30330260
  • 项目类别:
    重点项目
  • 资助金额:
    105.0万元
  • 批准年份:
    2003
  • 负责人:
    顾军
  • 依托单位: