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CONTROL OF NEURON POPULATION SIZE

CONTROL OF NEURON POPULATION SIZE
控制神经元数量
批准号:
3403567
负责人:
DAVID G SPERRY
金额:
$9.85万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-04-01 至 1993-03-31

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中文摘要
翻译
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英文摘要
The objectives of the proposed research are to study various factors which may affect the size of a neuron population during normal development. A prevailing explanation for the precise control of neuron numbers in that neurons and their targets are matched by a process involving competition between neurons and selective neuronal cell death. In the African clawed frog, Xenopus laevis, individual variation in the number of motoneurons in the lumbar lateral motor column is highly correlated with body size in both naturally occurring diploid and experimentally produced triploid animals. Whether this size-related variation in neuron number is produced by a competition process involving some feature of the hindlimb muscles innervated by these motoneurons is unclear since the significant correlation between motoneuron number and muscle fiber number observed in diploid animals is not observed in their triploid siblings. However, primary myotubes, a precursor of muscle fibers, may be the relevant feature of the target that limits motoneuron survival in both diploids and triploids. Correspondences between the average number of primary myotubes and the average number of motoneurons after cell death have been noted by other investigators, but the relationship between motoneuron number and myotube number in individual animals has never been determined. Two sets of experiments using Xenopus siblings are proposed to clarify the role that the primary myotubes may have in limiting motoneuron survival during normal development. First, after determining when primary myotube formation in a representative hindlimb muscle is complete, both the myotubes and the motoneurons in the same animals will be counted to measure the individual variation in these cell populations and to determine how the populations are related before motoneuronal cell death occurs. Second, because the free-living Xenopus larvae grow normally following hindlimb amputation, the myotubes in the muscle of an amputated limb will be counted and compared with the number of motoneurons (identified by retrograde labelling) innervating the muscle of the remaining limb after cell death. The hypothesis that myotube number is specifically relevant to motoneuron survival during normal development can be tested. In general, the information is relevant to understanding what processes are likely producing the natural variation in neuron number and the striking bilateral symmetry in neuron number observed after normal development.
期刊论文(7)
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会议论文
Central location of the motoneurons that supply the cucullaris (trapezius) of the clearnose skate, Raja eglanteria.
为明鼻鳐(Raja elanteria)的斜方肌(斜方肌)提供能量的运动神经元的中心位置。
DOI: 10.1016/0006-8993(92)90148-3
发表时间: 1992
期刊: Brain research
影响因子: 2.9
作者: [Sperry,DG, Boord,RL]
通讯作者: Boord,RL
Variation and symmetry in the lumbar and thoracic dorsal root ganglion cell populations of newly metamorphosed Xenopus laevis.
新变态的非洲爪蟾腰椎和胸椎背根神经节细胞群的变异和对称性。
DOI: 10.1002/cne.902920103
发表时间: 1990
期刊: The Journal of comparative neurology
影响因子: --
作者: [Sperry,DG]
通讯作者: Sperry,DG
Relationship between natural variations in motoneuron number and body size in Xenopus laevis: a test for size matching.
非洲爪蟾运动神经元数量自然变化与体型之间的关系:尺寸匹配测试。
DOI: 10.1002/cne.902640209
发表时间: 1987
期刊: The Journal of comparative neurology
影响因子: --
作者: [Sperry,DG]
通讯作者: Sperry,DG
Lumbar lateral motor column development in triploid Xenopus laevis.
三倍体非洲爪蟾的腰部横向运动柱发育。
DOI: 10.1002/cne.902780312
发表时间: 1988
期刊: The Journal of comparative neurology
影响因子: --
作者: [Sperry,DG]
通讯作者: Sperry,DG
共 6 条
    CONTROL OF NEURON POPULATION SIZE IN POLYPLOID ANURANS
    • 批准号:
      3403564
    • 项目类别:
    • 资助金额:
      $5.94万
    • 财政年份:
      1985
    • 负责人:
      DAVID G SPERRY
    • 依托单位:
    CONTROL OF NEURON POPULATION SIZE IN POLYPLOID ANURANS
    • 批准号:
      3403565
    • 项目类别:
    • 资助金额:
      $5.72万
    • 财政年份:
      1985
    • 负责人:
      DAVID G SPERRY
    • 依托单位:
    CONTROL OF NEURON POPULATION SIZE
    • 批准号:
      3403563
    • 项目类别:
    • 资助金额:
      $10.13万
    • 财政年份:
      1985
    • 负责人:
      DAVID G SPERRY
    • 依托单位:
    CONTROL OF NEURON POPULATION SIZE IN POLYPLOID ANURANS
    • 批准号:
      3403561
    • 项目类别:
    • 资助金额:
      $7.88万
    • 财政年份:
      1985
    • 负责人:
      DAVID G SPERRY
    • 依托单位:
    海外基金