BIOPHYSICAL ANALYSIS OF VESTIBULAR RECEPTORS

半规管的流体机械转导机制将是 通过使用小气泡的局部机械刺激进行研究 感受器内的磁性液体。传入反应动力学将是 以线性系统理论为特征的运动磁流体刺激 定位在受体内部的特定位置。流体假说 将通过比较传入反应来测试机械转导。 局部磁流体刺激与生理性刺激引起的 旋转加速度。吉他鱼垂直和水平管壶腹部 将会被使用。它们的形态大小差异将使 杯状传导中任何实验差异的相关性 大小不同的渠道之间的作用机制。孤立的迷宫 如果没有起作用的传出系统，将在第一个项目中使用。 将使用具有正常传出系统的慢性活体吉他鱼 在第二个项目中。长期目标是确定是否 流体力学机制可以解释不同的传入反应 在这种受体中发生的动力学。与健康相关的一个目标是 确定正常与升高(积水)体液的意义 迷路压力可能是梅尼埃综合征的发病机制。

Fluid mechanical transduction mechanisms of the semicircular canal will be investigated via local mechanical stimulation using small bubbles of magnetic fluid inside the receptor. Afferent response dynamics will be characterized with linear system theory to moving magnetic fluid stimuli positioned at specific locations inside the receptor. Hypotheses of fluid mechanical transduction will be tested by comparing the afferent responses to local magnetic fluid stimuli with those resulting from physiological rotational acceleration. Guitarfish vertical and horizontal canal ampullae will be used. Their morphological size differences will enable the correlation of any experimental differences in cupular transduction mechanisms among the canals with size differences. Isolated labyrinths without a functioning efferent system will be used in the first project. Chronic, in vivo guitarfish, with functioning efferent systems will be used in the second project. The long-term objective is to determine whether fluid mechanical mechanisms can account for the diverse afferent response dynamics occurring in this receptor. A health-related objective is to determine the significance of normal versus elevated (hydrops) fluid pressures in the labyrinth as a possible mechanism for Meniere's syndrome.