EXPERIMENTAL PNEUMOCONIOSIS OF SANDBLASTING SUBSTITUTES
EXPERIMENTAL PNEUMOCONIOSIS OF SANDBLASTING SUBSTITUTES
批准号:
3420197
负责人:
YEHIA Y HAMMAD
金额:
$8.06万
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-04-01 至 1987-03-31
中文摘要
在涂漆前使用喷砂清理钢结构
英文摘要
The use of sandblasting to clean steel structures before applying paint is
associated with severe and rapidly progressive silicosis. High morbidity
and mortality rates have been noted within a few years of exposure. The
U.S. Department of Labor has estimated the number of workers engaged in
sandblasting to be 78,000. Recognition of these hazards led to the
prohibition of sandblasting in Europe and Australia; in the U.S., sand
substitutes are now increasingly being used. They are derived from coal
ash residues and slag from smelting furnaces, and comprise various
proportions of amorphous silicates of Fe, Al, Ca, Mg and Ti. The free
silica content is only 0.03%.
The objective of this project is to develop a rat model to assess the
pulmonary fibrogenic potential of sand substitutes. Fibrotic effect from
prolonged exposure to the substitutes will be investigated in both normal
and silicotic rats. Silicosis will be induced in one group, followed by
exposure to the substitute; the second group will be exposed only to the
substitute. After exposure, both groups will be followed for an additional
twelve months. Appropriate control rats will be maintained for
comparisons. Rats will be sequentially sacrificed for histologic,
biochemical assay of collagen, and tissue mineral content evaluations.
This study will assess for the first time the safety of these substitutes.
We believe this rat model will have application in delineating and
predicting the potential occupational hazards for abrasive blasters with
and without pre-existing silicosis. Occupational exposure standards are
based on the assumption that the risk of any particular agent is not
influenced by exposure to other environmental factors. This study will
provide important information on the risk of lung fibrosis from biologic
interactions between different inhaled agents, which could affect the
future development of occupational standards. More specifically, this
project will demonstrate increased risk of progression of silicosis if
silicotic sandblasters use these substitutes.
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会议论文
A RATIONAL METHOD FOR SAMPLING AIRBONE FIBROGENIC DUST
-
批准号:3420757
-
项目类别:
-
资助金额:$7.76万
-
财政年份:1990
-
负责人:YEHIA Y HAMMAD
-
依托单位:
A RATIONAL METHOD FOR SAMPLING AIRBORNE FIBROGENIC DUST
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批准号:3420755
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项目类别:
-
资助金额:$9.2万
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财政年份:1988
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负责人:YEHIA Y HAMMAD
-
依托单位:
LONG TERM INDUSTRIAL HYGIENE PROGRAM TRAINING GRANT
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批准号:3528494
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项目类别:
-
资助金额:$5.31万
-
财政年份:1985
-
负责人:YEHIA Y HAMMAD
-
依托单位:
LONG TERM INDUSTRIAL HYGIENE PROGRAM TRAINING GRANT
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批准号:2278117
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项目类别:
-
资助金额:$5.37万
-
财政年份:1985
-
负责人:YEHIA Y HAMMAD
-
依托单位:
LONG TERM INDUSTRIAL HYGIENE PROGRAM TRAINING GRANT
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批准号:3528488
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项目类别:
-
资助金额:$4.93万
-
财政年份:1985
-
负责人:YEHIA Y HAMMAD
-
依托单位:
EXPERIMENTAL PNEUMOCONIOSIS OF SANDBLASTING SUBSTITUTES
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批准号:3420198
-
项目类别:
-
资助金额:$4.16万
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财政年份:1984
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负责人:YEHIA Y HAMMAD
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依托单位:
DOSE-RESPONSE MODELS FOR FIBROGENIC DUST INHALANTS
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批准号:4695045
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:YEHIA Y HAMMAD
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依托单位:
CORE--ENVIRONMENTAL CHARACTERIZATION
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批准号:4695053
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
-
负责人:YEHIA Y HAMMAD
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依托单位:
国内基金
海外基金
Aluminum/CFRP 混合管界面分层对渐进折叠机制影响研究
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批准号:ZCLQN26E0501
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项目类别:省市级项目
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资助金额:--
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批准年份:2026
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负责人:沈勇
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依托单位: