NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATE
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATE
批准号:
3408975
负责人:
FIROZE B JUNGALWALA
金额:
$16.97万
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-07-01 至 1991-03-31
关键词:
cell adhesion cell cell interaction cell cycle cell differentiation cell migration developmental neurobiology enzyme mechanism extracellular matrix glycolipids high performance liquid chromatography immunochemistry laboratory mouse laboratory rabbit laboratory rat lipid biosynthesis lipid structure mass spectrometry monoclonal antibody myelin glycoprotein neural cell adhesion molecules swine
中文摘要
这个项目的主要目标是研究这种化学物质
英文摘要
The major goal of this project is to investigate the chemical
structure, histological and topographical localization, biosynthesis
and regulation of expression of the noval sulfated glucuronyl
glycolipids (SGGL) in the developing nervous system. These
glycolipid antigens are stage specific and developmentally
regulated in the central nervous system during the important
period of cell differentiation and cell migration. The SGG epitope
is recognized by monoclonal antibody HNK-1, raised to surface
antigens on human natural killer cells. SGG epitope is also
expressed on a group of glycoproteins involved in cell-cell
interaction such as, neural cell adhesion molecules (N-CAMs),
myelin associated glycoprotein (MAG), and extra-cellular matrix
proteins, ependymins. The proper development of the nervous
system depends upon these molecules which are possibly involved
in cell division, cell migration and for specific afferent and
afferent connections. Studies are planned to determine the
precise structure of these glycolipids with respect to nature of
the carbohydrate, fatty acid, sphingosine base and glycosidic
linkages. Sensitive quantitative assay of the glycolipids will be
developed by using immunochemical, HPLC, and HPLC-mass
spectrometric techniques. Developmental expression of these
glycolipids in the different areas of the CNS will be studied.
Expression in various species and neurological mutants will be
investigated. The cellular and sub-cellular localization of SGGL
during embryonic development of the rat nervous system will be
studied by chemical and immunochemical methods. Biosynthesis
of the SGGL will be investigated by charaterizing the various
glycosyl transferases. Regulation of SGGL expression during
development will be studied by determining the expression of the
various glycosyl transferases and hydrolases. These basic studies
will lay the foundation for the future work on the functional role
of the SGG epitope on the glycolipids and glycoproteins.
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SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN NEUROGENESIS
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批准号:6608659
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项目类别:
-
资助金额:$10.66万
-
财政年份:2002
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN NEUROGENESIS
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批准号:6564623
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项目类别:
-
资助金额:$10.66万
-
财政年份:2001
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负责人:FIROZE B JUNGALWALA
-
依托单位:
CORE--CENTRAL INSTRUMENTATION CORE FACILITY
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批准号:6301846
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项目类别:
-
资助金额:$11.91万
-
财政年份:1999
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负责人:FIROZE B JUNGALWALA
-
依托单位:
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN THE DEVELOPING NERVOUS SYSTEM
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批准号:6301843
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项目类别:
-
资助金额:$11.91万
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财政年份:1999
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负责人:FIROZE B JUNGALWALA
-
依托单位:
CORE--CENTRAL INSTRUMENTATION CORE FACILITY
-
批准号:6108188
-
项目类别:
-
资助金额:$11.91万
-
财政年份:1998
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN THE DEVELOPING NERVOUS SYSTEM
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批准号:6108185
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项目类别:
-
资助金额:$11.91万
-
财政年份:1998
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负责人:FIROZE B JUNGALWALA
-
依托单位:
CORE--CENTRAL INSTRUMENTATION CORE FACILITY
-
批准号:6271953
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项目类别:
-
资助金额:$11.45万
-
财政年份:1997
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负责人:FIROZE B JUNGALWALA
-
依托单位:
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN THE DEVELOPING NERVOUS SYSTEM
-
批准号:6271950
-
项目类别:
-
资助金额:$11.45万
-
财政年份:1997
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN THE DEVELOPING NERVOUS SYSTEM
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批准号:6240772
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项目类别:
-
资助金额:$11.45万
-
财政年份:1996
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负责人:FIROZE B JUNGALWALA
-
依托单位:
CORE--CENTRAL INSTRUMENTATION CORE FACILITY
-
批准号:6240775
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项目类别:
-
资助金额:$11.45万
-
财政年份:1996
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负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:2265208
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项目类别:
-
资助金额:$21.87万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:2265211
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项目类别:
-
资助金额:$22.32万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:3408976
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项目类别:
-
资助金额:$21.85万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATE
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批准号:3408974
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项目类别:
-
资助金额:$16.38万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:6152163
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项目类别:
-
资助金额:$5.0万
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财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:2839316
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项目类别:
-
资助金额:$25.19万
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财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:2037254
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项目类别:
-
资助金额:$23.38万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:2609604
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项目类别:
-
资助金额:$24.25万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
-
批准号:3408973
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项目类别:
-
资助金额:$20.7万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:6473997
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项目类别:
-
资助金额:$0.0万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
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依托单位:
海外基金