NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
批准号:
6473997
负责人:
FIROZE B JUNGALWALA
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-07-01 至 2002-06-30
中文摘要
描述:(改编自申请人摘要)本研究的主要目标
英文摘要
DESCRIPTION: (adapted from Applicant's Abstract) The major goal of this
project is to understand the role of cell surface sulfoglucuronyl
glycolipids (SGGLs) and glycoproteins (SGGPs) which are stage
specifically regulated during development of the nervous system.
Sulfoglucuronyl carbohydrate, reactive with monoclonal antibody HNK-1,
is specifically expressed on an important group of molecules that are
involved in cell-cell interaction and adhesion. It has been proposed
that the sulfoglucuronyl carbohydrate is involved in cell
differentiation and cell-cell interactions.
This proposal focuses on the expression, regulation and function of this
carbohydrate, especially on SGGLs, during embryonic development and
neonatal development of the cerebral cortex and cerebellum. There are
three specific aims: 1) to determine whether SGGLs are expressed in
migrating immature external granule cells in neonatal cerebellum and to
test the hypothesis that down-regulation of SGGLs expression is related
to maturation of these cells, 2) to determine whether down-regulation
of the synthesis of SGGLs contributes to the loss of plasticity and
regeneration in the CNS, and 3) to test the hypothesis that HNK-1
carbohydrate, on primitive astrocytes in the nascent internal granule
cell layer of cerebellum, is a "stop-signal" for migrating granule
cells. These studies will be carried out on murine models known to have
abnormal cellular migration and developmental defects in the nervous
system as well as on normal mice. The results should generate
fundamental information about the role of HNK-1 carbohydrate in cell-
cell interactions and migration in the developing brain and further
define the molecular mechanisms involved in these processes. It should
also contribute to understanding abnormal brain development as well as
to the eventual ability to intervene clinically to correct neurological
disorders involving neuronal cell migration.
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DOI:
10.1016/s0076-6879(89)72033-4
发表时间:
1989
期刊:
Methods in enzymology
影响因子:
--
作者:
[R. McCluer;M. Ullman;F. Jungalwala]
通讯作者:
R. McCluer;M. Ullman;F. Jungalwala
Expression of sulfoglucuronyl (HNK-1) carbohydrate and its binding protein (SBP-1) in developing rat cerebellum.
磺基葡萄糖醛酸(HNK-1)碳水化合物及其结合蛋白(SBP-1)在发育中的大鼠小脑中的表达。
DOI:
10.1016/s0165-3806(00)00007-9
发表时间:
2000
期刊:
Brain research. Developmental brain research
影响因子:
--
作者:
[Zhao,Z, Chou,DK, Nair,SM, Tobet,S, Jungalwala,FB]
通讯作者:
Jungalwala,FB
Expression of neolactoglycolipids: sialosyl-, disialosyl-, O-acetyldisialosyl- and fucosyl- derivatives of neolactotetraosyl ceramide and neolactohexaosyl ceramide in the developing cerebral cortex and cerebellum.
新乳糖脂的表达:发育中的大脑皮层和小脑中新乳四糖基神经酰胺和新乳六糖基神经酰胺的唾液酸基-、二唾液酸基-、O-乙酰基二唾液酸基-和岩藻糖基-衍生物。
DOI:
10.1007/bf00731504
发表时间:
1996
期刊:
Glycoconjugate journal
影响因子:
3
作者:
[Chou,DK, Suzuki,Y, Jungalwala,FB]
通讯作者:
Jungalwala,FB
Characterization and developmental expression of lactotriosylceramide:galactosyltransferase for the synthesis of neolactotetraosylceramide in the nervous system.
乳三糖神经酰胺的表征和发育表达:用于神经系统中新乳四糖神经酰胺合成的半乳糖基转移酶。
DOI:
10.1046/j.1471-4159.1994.62010307.x
发表时间:
1994
期刊:
Journal of neurochemistry
影响因子:
4.7
作者:
[Chou,DK, Jungalwala,FB]
通讯作者:
Jungalwala,FB
Characterization of a sulfoglucuronyl carbohydrate binding protein in the developing nervous system.
发育中的神经系统中磺基葡萄糖醛酸糖结合蛋白的表征。
DOI:
10.1046/j.1471-4159.1997.68031286.x
发表时间:
1997
期刊:
Journal of neurochemistry
影响因子:
4.7
作者:
[Nair,SM, Jungalwala,FB]
通讯作者:
Jungalwala,FB
共 20 条
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN NEUROGENESIS
-
批准号:6608659
-
项目类别:
-
资助金额:$10.66万
-
财政年份:2002
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN NEUROGENESIS
-
批准号:6564623
-
项目类别:
-
资助金额:$10.66万
-
财政年份:2001
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
CORE--CENTRAL INSTRUMENTATION CORE FACILITY
-
批准号:6301846
-
项目类别:
-
资助金额:$11.91万
-
财政年份:1999
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN THE DEVELOPING NERVOUS SYSTEM
-
批准号:6301843
-
项目类别:
-
资助金额:$11.91万
-
财政年份:1999
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
CORE--CENTRAL INSTRUMENTATION CORE FACILITY
-
批准号:6108188
-
项目类别:
-
资助金额:$11.91万
-
财政年份:1998
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN THE DEVELOPING NERVOUS SYSTEM
-
批准号:6108185
-
项目类别:
-
资助金额:$11.91万
-
财政年份:1998
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负责人:FIROZE B JUNGALWALA
-
依托单位:
CORE--CENTRAL INSTRUMENTATION CORE FACILITY
-
批准号:6271953
-
项目类别:
-
资助金额:$11.45万
-
财政年份:1997
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN THE DEVELOPING NERVOUS SYSTEM
-
批准号:6271950
-
项目类别:
-
资助金额:$11.45万
-
财政年份:1997
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
SULFOGLUCURONYL (HNK-1) CARBOHYDRATE IN THE DEVELOPING NERVOUS SYSTEM
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批准号:6240772
-
项目类别:
-
资助金额:$11.45万
-
财政年份:1996
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
CORE--CENTRAL INSTRUMENTATION CORE FACILITY
-
批准号:6240775
-
项目类别:
-
资助金额:$11.45万
-
财政年份:1996
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:2265208
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项目类别:
-
资助金额:$21.87万
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财政年份:1987
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负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATE
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批准号:3408975
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项目类别:
-
资助金额:$16.97万
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财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:2265211
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项目类别:
-
资助金额:$22.32万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:3408976
-
项目类别:
-
资助金额:$21.85万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATE
-
批准号:3408974
-
项目类别:
-
资助金额:$16.38万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:6152163
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项目类别:
-
资助金额:$5.0万
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财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:2839316
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项目类别:
-
资助金额:$25.19万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
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批准号:2037254
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项目类别:
-
资助金额:$23.38万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
-
批准号:2609604
-
项目类别:
-
资助金额:$24.25万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
NEUROBIOLOGY OF SULFATED GLUCURONYL GLYCOCONJUGATES
-
批准号:3408973
-
项目类别:
-
资助金额:$20.7万
-
财政年份:1987
-
负责人:FIROZE B JUNGALWALA
-
依托单位:
海外基金