CRANIOFACIAL GROWTH IN GIANT TRANSGENIC RODENTS

这项试验性研究的目的是检查 巨大的转基因小鼠的颅面复合体。 这些小鼠 其特征是循环生长激素和总体 相对于同窝对照的体重。 与许多以前的研究不同， 这种分析是专门设计来区分这些一般 转基因小鼠的颅齿大小和形状变化， 身体尺寸的增加以及头骨的改变 反映区域和特定生长的形态或牙齿大小 扰动 假设转基因小鼠会表现出 面部的一些特殊生长变化， 整体体重增加。 本研究将联合收割机的异速生长分析 横截面增长数据与赖特（1932年）的一般层次， 组，和特殊的大小因素来检验这一假设。 这项研究将阐明头骨的激素控制方面 生长和牙齿大小，从而有助于我们了解正常的 以及颅面发育异常 头骨形状和牙齿大小的变化，或 出疹率常常是各种内分泌紊乱特征， 生长激素治疗师经常参与生长激素 治疗 这种参与在2010年可能会急剧增加。 未来，随着细菌DNA克隆hGH的可用性上升。 的 转基因小鼠，其“自然”产生的高水平的循环 生长激素，提供了一个重要的模型的影响，研究 生长激素治疗和内分泌失调 颅面复合体

The objective of this pilot research is to examine growth of the craniofacial complex in giant transgenic mice. These mice are characterized by marked increases in circulating growth hormone and overall body weight relative to littermate controls. Unlike many previous studies, this analysis is specifically designed to distinguish between those general craniodental size and shape changes in the transgenic mice that are merely a function of increased body size, and those alterations in skull morphology or tooth size that reflect regional and specific growth perturbations. The hypothesis is that the transgenic mice will exhibit some special growth changes in the face that are not simple correlates of overall weight gain. This study will combine allometric analysis of true cross-sectional growth data with Wright's (1932) hierarchy of general, group, and special size factors to test this hypothesis. This research will elucidate aspects of the hormonal control of skull growth and tooth size, and thus contribute to our understanding of normal and abnormal craniofacial growth. Changes in skull form and tooth size or eruption rate frequently characterize various endocrine disorders, and orthodontists are often involved in the ramifications of growth hormone therapies. This involvement will probably increase dramatically in the future, as the availability of hGH from bacterial DNA cloning rises. The transgenic mouse, with its "naturally" produced high levels of circulating growth hormone, provides an important model for the study of the effects of gigantism, growth hormone therapies, and endocrine disorders on the craniofacial complex.