CRANIOFACIAL GROWTH IN GIANT TRANSGENIC RODENTS

这项先导性研究的目的是考察 巨型转基因小鼠的头面部复合体。这些老鼠是 特点是循环中的生长激素显著增加，总体上 相对于产仔对照组的体重。与之前的许多研究不同， 本分析专门设计用来区分那些一般性的 转基因小鼠颅骨大小和形状的变化 一种身体尺寸增加的功能，以及头骨的变化 反映区域和特定生长的形态或牙齿大小 微扰。假设是转基因小鼠将会表现出 面部的一些特殊生长变化并不是简单的相关 总体体重增加。本研究将结合True的异速生长分析 具有Wright(1932)一般层次结构的横截面增长数据， 群体，和特殊的大小因素来检验这一假设。 这项研究将阐明颅骨激素控制的各个方面。 生长和牙齿大小，从而有助于我们理解正常 和异常的头面部发育。头骨形状和牙齿大小的变化或 皮疹发生率经常是各种内分泌疾病的特征，并且 正畸医生经常会受到生长激素的影响。 治疗。这种参与可能会在 未来，随着从细菌DNA克隆中获得hGH的可能性增加。这个 转基因小鼠，与其“自然”产生高水平的循环 生长激素，为研究生长激素的作用提供了重要模型。 巨人症、生长激素治疗和内分泌紊乱 头面部复合体。

The objective of this pilot research is to examine growth of the craniofacial complex in giant transgenic mice. These mice are characterized by marked increases in circulating growth hormone and overall body weight relative to littermate controls. Unlike many previous studies, this analysis is specifically designed to distinguish between those general craniodental size and shape changes in the transgenic mice that are merely a function of increased body size, and those alterations in skull morphology or tooth size that reflect regional and specific growth perturbations. The hypothesis is that the transgenic mice will exhibit some special growth changes in the face that are not simple correlates of overall weight gain. This study will combine allometric analysis of true cross-sectional growth data with Wright's (1932) hierarchy of general, group, and special size factors to test this hypothesis. This research will elucidate aspects of the hormonal control of skull growth and tooth size, and thus contribute to our understanding of normal and abnormal craniofacial growth. Changes in skull form and tooth size or eruption rate frequently characterize various endocrine disorders, and orthodontists are often involved in the ramifications of growth hormone therapies. This involvement will probably increase dramatically in the future, as the availability of hGH from bacterial DNA cloning rises. The transgenic mouse, with its "naturally" produced high levels of circulating growth hormone, provides an important model for the study of the effects of gigantism, growth hormone therapies, and endocrine disorders on the craniofacial complex.