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CRANIOFACIAL GROWTH IN GIANT TRANSGENIC RODENTS

巨型转基因啮齿动物的颅面生长

基本信息

批准号：
3425069
负责人：
BRIAN SHEA
金额：
$ 2.05万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
起止时间：
1986-02-01 至 1987-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3425069
关键词：
acromegaly body weight dental development disease /disorder model endocrine disorder face gigantisms growth /development hormone regulation /control mechanism model design /development molecular cloning skeletal disorder skull

项目摘要

The objective of this pilot research is to examine growth of the craniofacial complex in giant transgenic mice. These mice are characterized by marked increases in circulating growth hormone and overall body weight relative to littermate controls. Unlike many previous studies, this analysis is specifically designed to distinguish between those general craniodental size and shape changes in the transgenic mice that are merely a function of increased body size, and those alterations in skull morphology or tooth size that reflect regional and specific growth perturbations. The hypothesis is that the transgenic mice will exhibit some special growth changes in the face that are not simple correlates of overall weight gain. This study will combine allometric analysis of true cross-sectional growth data with Wright's (1932) hierarchy of general, group, and special size factors to test this hypothesis. This research will elucidate aspects of the hormonal control of skull growth and tooth size, and thus contribute to our understanding of normal and abnormal craniofacial growth. Changes in skull form and tooth size or eruption rate frequently characterize various endocrine disorders, and orthodontists are often involved in the ramifications of growth hormone therapies. This involvement will probably increase dramatically in the future, as the availability of hGH from bacterial DNA cloning rises. The transgenic mouse, with its "naturally" produced high levels of circulating growth hormone, provides an important model for the study of the effects of gigantism, growth hormone therapies, and endocrine disorders on the craniofacial complex.

这项试点研究的目的是检验巨型转基因小鼠的颅面复合体。这些老鼠是其特点是循环生长激素和总体水平显着增加相对于同窝对照的体重。与之前的许多研究不同，该分析是专门为了区分那些一般的转基因小鼠的颅齿大小和形状变化仅仅是身体尺寸增加以及头骨变化的功能反映区域和特定生长的形态或牙齿尺寸扰动。假设转基因小鼠将表现出面部的一些特殊生长变化与以下因素并不简单相关总体体重增加。这项研究将结合真实的异速生长分析横截面增长数据与赖特（1932）的一般层次结构，组和特殊的大小因素来检验这一假设。这项研究将阐明头骨荷尔蒙控制的各个方面生长和牙齿大小，从而有助于我们了解正常情况以及颅面生长异常。头骨形状和牙齿大小的变化或发疹率通常是各种内分泌失调的特征，并且正畸医生经常涉及生长激素的影响疗法。这种参与可能会急剧增加未来，随着细菌 DNA 克隆中 hGH 的可用性增加。这转基因小鼠，其“自然”产生高水平的循环生长激素为研究生长激素的作用提供了重要模型巨人症、生长激素疗法和内分泌失调颅面复合体。