PROSPECTIVE ANALYSIS OF MODEL OF WRITING AND SPELLING

书写和拼写模型的前瞻性分析

• 批准号: 3409648
• 负责人: DAVID P ROELTGEN
• 金额: $ 8.01万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3409648
• 关键词: brain injury; computed axial tomography; disease /disorder classification; human subject; language disorders; neural information processing; neuroanatomy; neuropsychology; parietal lobe /cortex; sensory disorder diagnosis

In order to better understand the neuropsychological mechanisms and anatomic loci that underlie acquired disorders of writing (and spelling), consecutive patients with acquired agraphias will be studied. The goal is to prospectively test a neuropsychological model of writing that was developed from preliminary studies and previous literature. These studies analyzed the behavior and pathological anatomy (by computerized tomography, CT) of the following agraphias: phonological, lexical, semantic and apractic. The proposed underlying anatomy included: supramarginal gyrus or underlying insula (phonological), posterior angular gyrus (lexical), areas thought to be important for language comprehension (semantic) and the parietal lobe (apractic). From these agraphias the specific functional components of the model were developed. They include linguistic (phonological, lexical, semantic) and motor components (graphemic area for apractic agraphia). In addition, the model proposes that there is a transitional phase when linguistic information is passed to the motor systems. Using a previously designed and normed writing, spelling and reading battery, as well as other language and non-language tests, the investigators will study a consecutive series of patients with left hemispheric lesions. All patients will be given the entire battery and all will have CT. The data generated from these tests will then be analyzed using a variety of statistical methods in order to validate or invalidate the behavioral and anatomic hypotheses predicted by the model. The results of this study will help lead to a better classification of the agraphias and a better understanding of the brain-behavior relationships underlying these common language disorders. Further development of a specific model of writing may lead to the development of additional therapeutic approaches to agraphia.

为了更好地理解神经心理学机制和 导致获得性书写（和拼写）障碍的解剖位点， 将研究连续患有获得性失写症的患者。 目标是 前瞻性地测试一种神经心理学写作模型 从初步研究和以前的文献中发展而来。 这些研究 分析行为和病理解剖（通过计算机断层扫描， CT）以下失写症：语音、词汇、语义和 实用的。 拟议的基础解剖结构包括： 边缘上回 或底层岛叶（语音），后角回（词汇）， 被认为对语言理解（语义）和 顶叶（实用）。 从这些失写症中可以看出具体的功能 开发了模型的组件。 它们包括语言学 （语音、词汇、语义）和运动成分（字母区域 实用性失写症）。 此外，该模型提出有一个 语言信息传递到电机的过渡阶段 系统。 使用先前设计和规范的写作、拼写和阅读 电池，以及其他语言和非语言测试， 研究人员将研究一系列连续的左脑患者 半球病变。 所有患者都将获得整个电池和所有 会有CT。 然后将分析这些测试生成的数据 使用各种统计方法来验证或无效 模型预测的行为和解剖假设。 这项研究的结果将有助于更好地分类 失写症和对大脑行为关系的更好理解 这些共同语言障碍的根源。 进一步开发一个 特定的写作模式可能会导致额外的发展 失写症的治疗方法。