PROSPECTIVE ANALYSIS OF MODEL OF WRITING AND SPELLING

为了更好地了解神经心理机制和 后天获得的书写(和拼写)障碍的解剖学基因座， 获得性失写的连续患者将被研究。我们的目标是 前瞻性地测试写作的神经心理学模型 从初步研究和以前的文献中发展而来。这些研究 分析行为和病理解剖(通过计算机断层扫描， Ct)以下失写症：语音、词汇、语义和 不切实际。建议的基本解剖包括：缘上回 或下层脑岛(语音)，后角回(词汇)， 被认为对语言理解(语义)和 顶叶(无实际的)。从这些失写体中可以看出特定的功能 开发了模型的组件。它们包括语言学 (语音、词汇、语义)和运动部件(字形区域 不切实际的失写症)。此外，该模型还提出存在一个 将语言信息传递给发动机的过渡阶段 系统。 使用先前设计和规范的写作、拼写和阅读 电池，以及其他语言和非语言测试， 研究人员将研究一系列连续的左撇子患者 大脑半球的损伤。所有患者都将得到整个电池和所有 会做CT检查。然后将分析从这些测试中产生的数据 使用各种统计方法来验证或无效 模型预测的行为学和解剖学假说。 这项研究的结果将有助于更好地对 失写症和对大脑-行为关系的更好理解 这些共同语言障碍的潜在原因。进一步开发了一种 特定的写作模式可能会导致额外的 治疗失写的方法。

In order to better understand the neuropsychological mechanisms and anatomic loci that underlie acquired disorders of writing (and spelling), consecutive patients with acquired agraphias will be studied. The goal is to prospectively test a neuropsychological model of writing that was developed from preliminary studies and previous literature. These studies analyzed the behavior and pathological anatomy (by computerized tomography, CT) of the following agraphias: phonological, lexical, semantic and apractic. The proposed underlying anatomy included: supramarginal gyrus or underlying insula (phonological), posterior angular gyrus (lexical), areas thought to be important for language comprehension (semantic) and the parietal lobe (apractic). From these agraphias the specific functional components of the model were developed. They include linguistic (phonological, lexical, semantic) and motor components (graphemic area for apractic agraphia). In addition, the model proposes that there is a transitional phase when linguistic information is passed to the motor systems. Using a previously designed and normed writing, spelling and reading battery, as well as other language and non-language tests, the investigators will study a consecutive series of patients with left hemispheric lesions. All patients will be given the entire battery and all will have CT. The data generated from these tests will then be analyzed using a variety of statistical methods in order to validate or invalidate the behavioral and anatomic hypotheses predicted by the model. The results of this study will help lead to a better classification of the agraphias and a better understanding of the brain-behavior relationships underlying these common language disorders. Further development of a specific model of writing may lead to the development of additional therapeutic approaches to agraphia.