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ANTERIOR TEMPORAL LOBECTOMY--TWO SURGICAL METHODS

ANTERIOR TEMPORAL LOBECTOMY--TWO SURGICAL METHODS
前颞叶切除术--两种手术方法
批准号:
3415305
负责人:
Bruce Phillip Hermann
金额:
$13.21万
依托单位国家:
美国
项目类别:
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-06-01 至 1993-11-30

项目摘要

项目成果

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中文摘要
翻译
这项拨款建议对癫痫发作进行前瞻性的纵向研究, 前路手术的精神病学、神经心理学和职业结局 颞叶切除术治疗复杂部分性癫痫 起源于颞叶。ATL将由一个外科团队完成,但 患者将被随机分成两个手术组。一组患者 将通过标准的“整块”切除来完成ATL。另一位病人 各组将有复杂的部分性癫痫发作,发作期为近侧发作 并且将不会具有因果结构损害(即, 肿瘤或动静脉畸形)经MRI扫描证实。研究结果将:(1)有助于 阐明海马体在非损伤性颞叶癫痫中的作用 (2)帮助澄清几种ATL方法中哪种方法产生的效果最好 癫痫发作结局与最小的心理和精神损害 病人。这项建议直接适用于最近的 美国国立卫生研究院癫痫手术共识会议。
英文摘要
This grant proposes a prospective longitudinal study of the seizure, psychiatric, neuropsychological, and vocational outcome of anterior temporal lobectomy (ATL) done for treatment of complex partial seizures of temporal lobe origin. ATL will be done by one surgical team but the patients will be randomized into two surgical groups. One patient group will have ATL done by a standard "en bloc" resection. The other patient groups will have complex partial seizures with ictal onset from mesial temporal structures and will not have a causal structural lesion (i.e., tumor or AVM) documented by MRI scan. The outcome of study will: (1) help clarify the role of hippocampus in nonlesional temporal lobe epilepsy, and (2) help clarify the which of several methods of ATL produce the best seizure outcome with minimal psychological and psychiatric impairment to patients. This proposal apples directly to the conclusion of the recent NIH consensus conference of Epilepsy Surgery.
期刊论文(5)
专著(0)
科研奖励(0)
会议论文
Pathological status of the mesial temporal lobe predicts memory outcome from left anterior temporal lobectomy.
内侧颞叶的病理状态可预测左前颞叶切除术的记忆结果。
DOI: 10.1227/00006123-199210000-00006
发表时间: 1992
期刊: Neurosurgery
影响因子: 4.8
作者: [Hermann,BP, Wyler,AR, Somes,G, Berry3rd,AD, DohanJr,FC]
通讯作者: DohanJr,FC
DOI: 10.1227/00006123-199511000-00019
发表时间: 1995-11
期刊: Neurosurgery
影响因子: 4.8
作者: [A. Wyler;B. Hermann;G. Somes;D. Spencer;D. Roberts;J. Engel]
通讯作者: A. Wyler;B. Hermann;G. Somes;D. Spencer;D. Roberts;J. Engel
NEUROPSYCHOLOGICAL PROGESSION IN NEW ONSET EPILEPSY
NEUROPSYCHOLOGICAL PROGESSION IN NEW ONSET EPILEPSY
NEUROPSYCHOLOGICAL PROGESSION IN NEW ONSET EPILEPSY
NEUROPSYCHOLOGICAL PROGESSION IN NEW ONSET EPILEPSY
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