Advanced laser-ion acceleration strategies towards next generation healthcare

面向下一代医疗保健的先进激光离子加速策略

• 批准号: EP/K022415/1
• 负责人: Marco Borghesi
• 金额: $ 583.19万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FK022415%2F1
• 关键词: Advanced; laser; ion; acceleration; strategies

The project aims to reach an important milestone towards the development of innovative healthcare technologies: all-optical delivery of dense, high-repetition ion beams at energies above the threshold for deep-seated tumour treatment and diagnosis (~200 MeV/nucleon). Driven from an immediate impact in accelerator science, the flexibility and compactness of the planned solutions, jointly with other potential advantages of laser-based systems, could revolutionise cancer treatment methods. The extreme conditions reached during the interaction of an ultra-intense laser pulse with matter can lead, if suitably controlled, to the rapid acceleration of beams of ions with unique properties. The study of these laser-initiated acceleration mechanisms, and the characterization and optimization of the ion beams produced, have been, over the past decade, one of the most active and fruitful areas of high-field science. UK scientists have been at the forefront of the development of laser-driven ion sources. During the final stages of LIBRA, novel acceleration mechanisms have emerged, mostly based on the enormous pressure exerted by powerful laser pulses onto irradiated matter, which promise a step change in particle acceleration capabilities. A key area of application of high-current ion beams (proton and carbon) is in cancer therapy. Through a series of coordinated and interlinked activities over a 6 year period, we aim to advance laser-ion acceleration to the point at which laser-driven beams will become a serious alternative to conventional RF accelerators for medical therapy. Besides offering a reduction in cost and footprint of particle therapy centres (major factors limiting their growth worldwide), a laser-driven approach would offer a number of advantageous features currently unavailable: on-demand switching between species (H and C, with options for other light ions such Be and Li) and energy control; enhanced diagnosis, with synchronized proton and x-ray pulses, and on-site isotope production for Positron Emission Tomography. Our ambition is for UK science to play a leading role in the development of high-energy ion sources, by capitalizing on the exceptional pool of expertise available to our consortium.

该项目旨在实现创新医疗技术发展的一个重要里程碑：以高于深层肿瘤治疗和诊断阈值（约200 MeV/核子）的能量全光学输送密集、高重复离子束。在加速器科学的直接影响下，计划解决方案的灵活性和紧凑性，以及基于激光的系统的其他潜在优势，可能会彻底改变癌症治疗方法。在超强激光脉冲与物质相互作用过程中达到的极端条件，如果得到适当的控制，可以导致具有独特性质的离子束的快速加速。这些激光引发的加速机制的研究，以及产生的离子束的表征和优化，在过去的十年中，一直是高场科学最活跃和最富有成果的领域之一。英国科学家一直处于激光驱动离子源发展的最前沿。在LIBRA的最后阶段，出现了新的加速机制，主要是基于强大的激光脉冲对辐照物质施加的巨大压力，这有望使粒子加速能力发生阶跃变化。高电流离子束（质子和碳）的一个关键应用领域是癌症治疗。通过一系列协调和相互关联的活动，在6年的时间里，我们的目标是推进激光离子加速的点，激光驱动的光束将成为一个严重的替代传统的射频加速器的医疗。除了降低粒子治疗中心的成本和占地面积外，（限制其在全球范围内增长的主要因素），激光驱动的方法将提供许多目前尚不具备的有利功能：（H和C，可选择其他轻离子，如Be和Li）和能量控制;增强诊断，同步质子和X射线脉冲，以及现场同位素生产的正电子发射断层扫描。我们的目标是让英国科学在高能离子源的发展中发挥主导作用，利用我们联盟的特殊专业知识。

项目成果

Efficient post-acceleration of protons in helical coil targets driven by sub-ps laser pulses.

• DOI: 10.1038/s41598-017-06985-4
• 发表时间: 2017-09-07
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Ahmed H;Kar S;Cantono G;Hadjisolomou P;Poye A;Gwynne D;Lewis CLS;Macchi A;Naughton K;Nersisyan G;Tikhonchuk V;Willi O;Borghesi M
• 通讯作者: Borghesi M

Parametric study of a high amplitude electromagnetic pulse driven by an intense laser

• DOI: 10.1063/1.5094871
• 发表时间: 2019-07-01
• 期刊: PHYSICS OF PLASMAS
• 影响因子: 2.2
• 作者: Aktan, E.;Ahmed, H.;Prasad, P.
• 通讯作者: Prasad, P.

Investigations of ultrafast charge dynamics in laser-irradiated targets by a self probing technique employing laser driven protons

• DOI: 10.1016/j.nima.2016.04.078
• 发表时间: 2016-09-01
• 期刊: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT
• 影响因子: 1.4
• 作者: Ahmed, H.;Kar, S.;Borghesi, M.
• 通讯作者: Borghesi, M.

Experimental Observation of Thin-shell Instability in a Collisionless Plasma

• DOI: 10.3847/2041-8213/834/2/l21
• 发表时间: 2017-01
• 期刊: The Astrophysical Journal Letters
• 作者: H. Ahmed;D. Doria;M. Dieckmann;G. Sarri;L. Romagnani;A. Bret;M. Cerchez;A. Giesecke;E. Ianni;S. Kar;M. Notley;R. Prasad;K. Quinn;O. Willi;M. Borghesi

Proton probing of laser-driven EM pulses travelling in helical coils

• DOI: 10.1017/hpl.2016.47
• 发表时间: 2017
• 期刊: High Power Laser Science and Engineering
• 影响因子: 4.8
• 作者: H. Ahmed;S. Kar;A. Giesecke;D. Doria;G. Nersisyan;O. Willi;C. Lewis;M. Borghesi