RECEPTIVE FIELDS OF LAYER IV (BARREL FIELD) NEURONS

第四层（桶状场）神经元的感受野

• 批准号: 3411445
• 负责人: Ford Francis Ebner
• 金额: $ 11.64万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-09-25 至 1994-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3411445
• 关键词: NMDA receptors; brain electrical activity; histology; laboratory rat; microscopy; neocortex; neural information processing; neuroanatomy; neuropharmacology; neurophysiology; sensory feedback; somesthetic sensory cortex; stimulus /response; synapses; thalamocortical tract

Sensory systems in mammals consist of multiple pathways from the peripheral receptors to neocortex. Of these, only one is organized for transmitting the precise physical characteristics of sensory stimuli. The proposed experiments are designed to show the organization and function of parallel somatic sensory pathways. Preliminary results indicate that, of the multiple somatic pathways carrying information from the whiskers to the barrel field cortex of rat, only the 'lemniscal' pathway through the medial subdivision of the thalamic ventral posterior nucleus (VPM) is capable of maintaining the sensory responsiveness of neurons in the barrel field. The general thesis is that the 'paralemniscal' pathway through the thalamic posterior nucleus (PO), terminating in septa surrounding cortical barrels, regulates the excitability of septal neurons; by modulating the horizontal distance in cortex across which activity spreads, PO controls the degree of interaction and association between inputs from VPM terminating in separate barrels. To test this hypothesis, we will identify with anatomical transport methods the locations in cortex at which lemniscal and paralemniscal inputs converge. Then we will measure the effect of stimulation of PO on the magnitude and horizontal spread of cortical activity evoked by movement of a single whisker. The PO stimulation will be delivered either synchronously with whisker movement or out of phase with whisker movement. We will then measure the influence of PO stimulation on the plasticity of cortical receptive fields induced by temporally paired movement of whiskers. Finally, we will investigate the role of glutamate receptors in barrel field receptive field plasticity.

哺乳动物的感觉系统由多条通路组成， 新皮层的受体 其中只有一个是有组织的， 感官刺激的精确物理特征。 拟议 设计实验来展示并行的组织和功能。 躯体感觉通路 初步结果显示， 多条躯体通路将信息从触须传递到 大鼠桶场皮质，只有'丘系'通路通过内侧 丘脑腹后核（VPM）的分部能够 维持桶场中神经元的感觉反应性。 的 一般的论点是，通过丘脑的“神经系”通路 后核（PO），终止于围绕皮质桶的隔， 调节隔神经元的兴奋性;通过调节水平 活动传播的皮层距离，PO控制程度 VPM输入之间的交互和关联， 分开的桶。为了验证这一假设，我们将认同解剖学 运输方法在皮层的位置， 双系输入收敛。然后我们将测量 刺激PO对皮层神经元数量和水平分布的影响 由一根胡须的运动引起的活动。 PO刺激将 与须状体运动同步或异相地输送 胡须的运动。 然后我们将测量PO的影响 刺激皮层感受野的可塑性 胡须在时间上成对的运动。 最后，我们将调查 谷氨酸受体在桶场感受野可塑性中的作用。