EPSRC Centre for Innovative Manufacturing in Medical Devices

EPSRC 医疗器械创新制造中心

• 批准号: EP/K029592/1
• 负责人: John Fisher
• 金额: $ 722.07万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FK029592%2F1
• 关键词: EPSRC; Centre; Innovative; Manufacturing; Medical

The EPSRC Centre in Innovative Manufacturing in Medical Devices will research and develop advanced methods for functionally stratified design and near patient manufacturing, to enable cost effective matching of device function to the patient needs and surgical environment. This will deliver "the right product, by the right process to the right patient at the right time" to an enhanced standard of reliability and performance. The centre will research and develop:1) Functionally stratified design systems, which will be initially applied to existing device manufacturing processes and subsequently to the manufacture of scaffolds, developing novel pre-clinical simulation methods, which match implant design to patient function, delivering a cost effective Stratified Approach for Enhanced Reliability (SAFER)2) Innovative near patient manufacturing processes, enabled by stratified and individualised definitions of patient need, to provide a more cost effective approach to personalised devices.The two flagship challenges will be integrated with the key platform capabilities, across the centre to generate, for the first time, a closed loop design and manufacturing framework for medical devices to deliver enhanced performance and reliability. These innovative design and manufacturing advances will focus in the first instance on class 3 medical devices for musculoskeletal disease, where the cost of device failure and need for throughout life reliability are high. The National Centre will develop, lead and integrate an international network of industrialists, academics, clinicians and regulatory body representatives in order to support the musculoskeletal medical device manufacturing industry to deliver the innovative design and manufacturing challenges and implement the outcomes into manufacturing practice in a global highly regulated market. The Centre will create the research infrastructure, tools and methods, expertise and suitably qualified personnel to support continued innovation and growth of the medical device manufacturing sector in the UK. To do so, the Centre will work across the EPSRC priority research areas "Manufacturing the Future" and "Towards next generation healthcare," drawing upon capabilities and collaborating with existing centres of excellence. The Centre will provide a platform for fundamental innovative device manufacturing research and promote its rapid exploitation by industry through outreach and translation activities and a generic platform for diversification into other technologies. It will grow the UK's research capability in medical device manufacturing research to underpin the development of next generation medical devices and the development of high quality manufacturing processes to provide cost effective, reliable and effective devices. It will be applied to enhanced manufacturing of existing devices such as joint replacements and support manufacture of new products and biomaterial scaffolds. The Centre will operate across five leading academic centres of excellence in the field. The Centre will be led by Leeds University (Fisher, Williams, Ingham, Wilcox, Jennings and Redmond) and will be supported by collaboration from Newcastle (Dalgarno and McKaskie), Nottingham (Grant, Ahmed and Warrior), Sheffield (Hatton) and Bradford (Coates). The Centre will work closely with major manufacturers and users including surgeons who see at first hand the challenges of patient and surgical variation. The Centre will provide a platform for developing fundamental medical device manufacturing science and promote its rapid exploitation by industry.

EPSRC医疗器械创新制造中心将研究和开发功能分层设计和近患者制造的先进方法，以实现设备功能与患者需求和手术环境的成本效益匹配。这将“通过正确的流程，在正确的时间为正确的患者提供正确的产品”，从而提高可靠性和性能标准。该中心将研究和开发：1)功能分层设计系统，该系统将最初应用于现有的设备制造过程，随后应用于支架的制造，开发新的临床前模拟方法，使植入物设计与患者功能相匹配，提供具有成本效益的增强可靠性分层方法（SAFER）2)创新的近患者制造过程。通过对患者需求的分层和个性化定义，为个性化设备提供更具成本效益的方法。这两个旗舰挑战将与整个中心的关键平台功能集成，首次为医疗设备生成闭环设计和制造框架，以提供增强的性能和可靠性。这些创新的设计和制造进步将首先集中在用于肌肉骨骼疾病的3类医疗设备上，在这些设备中，设备故障的成本和对整个寿命可靠性的需求很高。国家中心将发展、领导和整合一个由工业家、学者、临床医生和监管机构代表组成的国际网络，以支持肌肉骨骼医疗设备制造业在全球高度监管的市场中提供创新的设计和制造挑战，并将成果实施到制造实践中。该中心将创建研究基础设施、工具和方法、专业知识和适当合格的人员，以支持英国医疗器械制造业的持续创新和增长。为此，该中心将在EPSRC的优先研究领域“制造未来”和“迈向下一代医疗保健”开展工作，利用现有的卓越中心的能力并与之合作。该中心将为基础创新设备制造研究提供一个平台，并通过外联和翻译活动促进其迅速被工业利用，并为其他技术的多样化提供一个通用平台。它将增加英国在医疗设备制造研究方面的研究能力，以支持下一代医疗设备的发展和高质量制造工艺的发展，以提供具有成本效益、可靠和有效的设备。它将应用于增强现有设备的制造，如关节置换和支持新产品和生物材料支架的制造。该中心将在该领域五个领先的卓越学术中心开展业务。该中心将由利兹大学（Fisher, Williams, Ingham, Wilcox， Jennings和Redmond）领导，并将得到纽卡斯尔（Dalgarno和McKaskie），诺丁汉（Grant， Ahmed和Warrior），谢菲尔德（Hatton）和布拉德福德（Coates）的合作支持。该中心将与主要制造商和用户密切合作，包括亲眼目睹患者和手术变化挑战的外科医生。该中心将为发展基础医疗器械制造科学提供平台，并促进其快速产业化。

项目成果

Bioactive and Topographically-Modified Electrospun Membranes for the Creation of New Bone Regeneration Models

• DOI: 10.3390/pr8111341
• 发表时间: 2020-11-01
• 期刊: PROCESSES
• 影响因子: 3.5
• 作者: Abdelmoneim, Dina;Alhamdani, Ghsaq M.;Asencio, Ilida Ortega
• 通讯作者: Asencio, Ilida Ortega

Wear of composite ceramics in mixed-material combinations in total hip replacement under adverse edge loading conditions.

• DOI: 10.1002/jbm.b.33671
• 发表时间: 2017-08
• 期刊: Journal of biomedical materials research. Part B, Applied biomaterials
• 作者: Al-Hajjar M;Carbone S;Jennings LM;Begand S;Oberbach T;Delfosse D;Fisher J
• 通讯作者: Fisher J

A comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements.

全面的实验和计算框架，用于临时磨损的总膝盖置换。

• DOI: 10.1016/j.jmbbm.2017.11.022
• 发表时间: 2018-03
• 期刊: Journal of the mechanical behavior of biomedical materials
• 影响因子: 3.9
• 作者: Abdelgaied A;Fisher J;Jennings LM
• 通讯作者: Jennings LM

A comparison between electromechanical and pneumatic-controlled knee simulators for the investigation of wear of total knee replacements.

• DOI: 10.1177/0954411917696519
• 发表时间: 2017-07
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Abdelgaied A;Fisher J;Jennings LM
• 通讯作者: Jennings LM

The effect of insert conformity and material on total knee replacement wear.

• DOI: 10.1177/0954411913513251
• 发表时间: 2014-01
• 期刊: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
• 作者: Abdelgaied A;Brockett CL;Liu F;Jennings LM;Jin Z;Fisher J
• 通讯作者: Fisher J