EPSRC Centre for Innovative Manufacturing in Medical Devices

EPSRC 医疗器械创新制造中心

基本信息

批准号：
EP/K029592/1
负责人：
John Fisher
金额：
$ 722.07万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FK029592%2F1
关键词：
EPSRC Centre Innovative Manufacturing Medical

项目摘要

The EPSRC Centre in Innovative Manufacturing in Medical Devices will research and develop advanced methods for functionally stratified design and near patient manufacturing, to enable cost effective matching of device function to the patient needs and surgical environment. This will deliver "the right product, by the right process to the right patient at the right time" to an enhanced standard of reliability and performance. The centre will research and develop:1) Functionally stratified design systems, which will be initially applied to existing device manufacturing processes and subsequently to the manufacture of scaffolds, developing novel pre-clinical simulation methods, which match implant design to patient function, delivering a cost effective Stratified Approach for Enhanced Reliability (SAFER)2) Innovative near patient manufacturing processes, enabled by stratified and individualised definitions of patient need, to provide a more cost effective approach to personalised devices.The two flagship challenges will be integrated with the key platform capabilities, across the centre to generate, for the first time, a closed loop design and manufacturing framework for medical devices to deliver enhanced performance and reliability. These innovative design and manufacturing advances will focus in the first instance on class 3 medical devices for musculoskeletal disease, where the cost of device failure and need for throughout life reliability are high. The National Centre will develop, lead and integrate an international network of industrialists, academics, clinicians and regulatory body representatives in order to support the musculoskeletal medical device manufacturing industry to deliver the innovative design and manufacturing challenges and implement the outcomes into manufacturing practice in a global highly regulated market. The Centre will create the research infrastructure, tools and methods, expertise and suitably qualified personnel to support continued innovation and growth of the medical device manufacturing sector in the UK. To do so, the Centre will work across the EPSRC priority research areas "Manufacturing the Future" and "Towards next generation healthcare," drawing upon capabilities and collaborating with existing centres of excellence. The Centre will provide a platform for fundamental innovative device manufacturing research and promote its rapid exploitation by industry through outreach and translation activities and a generic platform for diversification into other technologies. It will grow the UK's research capability in medical device manufacturing research to underpin the development of next generation medical devices and the development of high quality manufacturing processes to provide cost effective, reliable and effective devices. It will be applied to enhanced manufacturing of existing devices such as joint replacements and support manufacture of new products and biomaterial scaffolds. The Centre will operate across five leading academic centres of excellence in the field. The Centre will be led by Leeds University (Fisher, Williams, Ingham, Wilcox, Jennings and Redmond) and will be supported by collaboration from Newcastle (Dalgarno and McKaskie), Nottingham (Grant, Ahmed and Warrior), Sheffield (Hatton) and Bradford (Coates). The Centre will work closely with major manufacturers and users including surgeons who see at first hand the challenges of patient and surgical variation. The Centre will provide a platform for developing fundamental medical device manufacturing science and promote its rapid exploitation by industry.

EPSRC在医疗设备中的创新制造中心将研究和开发用于功能分层设计和近乎患者制造的高级方法，以使设备功能的成本效益匹配到患者需求和手术环境。这将在正确的时间通过正确的患者提供“正确的产品”，以增强的可靠性和性能标准。该中心将研究和开发：1）功能分层的设计系统，该系统将最初应用于现有的设备制造过程，然后将其应用于脚手架的制造，开发新型的临床前模拟方法，这些方法与患者的功能相匹配，这些方法与患者的功能相匹配，为成本有效的分层方法提供了一种用于增强的可靠性（SAFER），以实现较大的患者，并提供了一个创新的患者，以实现型号，以实现型号，以实现分层，以构成型号，以构成启用的处理，并提供一定的分层，并提供一定的分层，以构建一定的分层，并提供一定的分层，并提供一定的分层。设备。这两个旗舰挑战将与中心跨中心的关键平台功能集成，以首次生成医疗设备的闭环设计和制造框架，以提供增强的性能和可靠性。这些创新的设计和制造业的进步将首先集中在肌肉骨骼疾病的3级医疗设备上，在这种情况下，设备故障的成本和整个生活可靠性的需求很高。国家中心将开发，领导和整合一个国际工业家，学者，临床医生和监管机构代表网络，以支持肌肉骨骼医疗设备制造业，以提供创新的设计和制造挑战，并在全球受高度监管的市场中实施淘汰型制造实践。该中心将创建研究基础设施，工具和方法，专业知识以及合格的人员，以支持英国医疗设备制造业的持续创新和增长。为此，该中心将在EPSRC优先研究领域“制造未来”和“迈向下一代医疗保健”，利用能力并与现有卓越中心合作。该中心将提供一个基本创新设备制造研究的平台，并通过外展和翻译活动来促进行业的迅速剥削，以及将多元化为其他技术多样化的通用平台。它将扩大英国在医疗设备制造研究中的研究能力，以支持下一代医疗设备的开发以及高质量制造工艺的开发，以提供具有成本效益，可靠和有效的设备。它将应用于增强现有设备的制造，例如关节置换和支持新产品和生物材料脚手架的制造。该中心将在该领域的五个领先的卓越学术中心运作。该中心将由利兹大学（Fisher，Williams，Ingham，Wilcox，Jennings和Redmond）领导，并将受到纽卡斯尔（Dalgarno和McKaskie），诺丁汉（Grant，Ahmed和Warrior），Sheffield（Sheffield）（Hatton）和Bradford（Coates）的合作的支持。该中心将与主要制造商和用户紧密合作，包括外科医生，他们亲眼看到患者和手术变异的挑战。该中心将为开发基本医疗设备制造科学的平台提供一个平台，并促进其行业快速剥削。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Bioactive and Topographically-Modified Electrospun Membranes for the Creation of New Bone Regeneration Models

DOI：
10.3390/pr8111341
发表时间：
2020-11-01
期刊：
PROCESSES
影响因子：
3.5
作者：
Abdelmoneim, Dina;Alhamdani, Ghsaq M.;Asencio, Ilida Ortega
通讯作者：
Asencio, Ilida Ortega

A comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements.

DOI：
10.1016/j.jmbbm.2017.11.022
发表时间：
2018-03
期刊：
Journal of the mechanical behavior of biomedical materials
影响因子：
3.9
作者：
Abdelgaied A;Fisher J;Jennings LM
通讯作者：
Jennings LM

Wear of composite ceramics in mixed-material combinations in total hip replacement under adverse edge loading conditions.

DOI：
10.1002/jbm.b.33671
发表时间：
2017-08
期刊：
Journal of biomedical materials research. Part B, Applied biomaterials
影响因子：
0
作者：
Al-Hajjar M;Carbone S;Jennings LM;Begand S;Oberbach T;Delfosse D;Fisher J
通讯作者：
Fisher J

A comparison between electromechanical and pneumatic-controlled knee simulators for the investigation of wear of total knee replacements.

DOI：
10.1177/0954411917696519
发表时间：
2017-07
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
0
作者：
Abdelgaied A;Fisher J;Jennings LM
通讯作者：
Jennings LM

Assessment of tests for use in process and quality control systems for selective laser sintering of polyamide powders