A cellular identity crisis: Deciphering how mammary epithelial cells form and maintain their identity

细胞身份危机：破译乳腺上皮细胞如何形成和维持其身份

• 批准号: nhmrc : 2003832
• 金额: $ 84.38万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/a-cellular-identity-maintain-identity/1780221
• 关键词: cellular; identity; crisis; Deciphering; how

The ability to regenerate human organs from adult cells efficiently and without error is a major goal of biomedical research in Australia, with significant economic benefits. As one of the most regenerative organs in a woman's body, the breast is an excellent model to study mechanisms that underpin tissue growth and regrowth. Moreover, as these pathways are often hijacked by cancer, this research has important implications for the development of new targeted therapies to treat breast cancer.

从成体细胞中有效且无错误地再生人体器官的能力是澳大利亚生物医学研究的主要目标，具有显着的经济效益。作为女性身体中最具再生能力的器官之一，乳房是研究组织生长和再生机制的绝佳模型。此外，由于这些途径经常被癌症劫持，这项研究对开发治疗乳腺癌的新靶向疗法具有重要意义。