Mental Health in Autistic Adults: An RDoC Approach

成人自闭症患者的心理健康：RDoC 方法

• 批准号: 10523166
• 负责人: BENJAMIN L HANDEN
• 金额: $ 51.02万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-06 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10523166
• 关键词: Adherence; Adult; Adverse event; Age; Aging; Algorithms; Anxiety; Appointment; Attention deficit hyperactivity disorder; Biological Markers; Brain; Clinical; Clinical Data; Collaborations; Communication; Communities; Consent; Crisis Intervention; Data; Diagnosis; Diagnostic; Differential Diagnosis; Dimensions; Documentation; Electronic Mail; Enrollment; Ensure; Ethnic Origin; Feeling suicidal; Female; Funding; Funding Mechanisms; Goals; Grant; Health Personnel; Individual; Intellectual functioning disability; Lead; Machine Learning; Measures; Mental Depression; Mental Health; Methods; Monitor; Newsletter; Participant; Personality Disorders; Persons; Phenotype; Probability; Procedures; Process; Productivity; Protocols documentation; Psychiatric Diagnosis; Race; Recording of previous events; Recruitment Activity; Registries; Reporting; Research; Research Domain Criteria; Research Personnel; Research Project Grants; Resources; Risk; Rural; Safety; Schedule; Services; Structure; Suicide; Symptoms; System; Time; Training; Ulysses Contracts; Uncertainty; United States National Institutes of Health; Update; Visit; adult with autism spectrum disorder; age related; autism spectrum disorder; autistic; base; cognitive testing; cohort; diagnostic screening; ethnic identity; experience; human old age (65+); inclusion criteria; indexing; innovation; marginalized population; meetings; novel; participant retention; phenotypic data; programs; racial identity; recruit; response; satisfaction; service intervention; sex; success; suicidal behavior; suicidal risk; theories; tool

Clinical Core Abstract The purpose of the Clinical Core is 1): To manage recruitment activities and consent and enroll a Pittsburgh ACE Cohort for participation in the three Projects. We will prioritize increased participation by individuals traditionally minoritized in ASD research (e.g., race/ethnicity, LGBTQIA+, females, and diagnosis of ASD in adulthood); 2): Administer, score, and enter data for ASD diagnostic assessments and administer all RFA- required and center-wide phenotypic measures; 3) Apply a novel posterior probability of diagnosis (PPOD) index to estimate the presence of psychiatric diagnoses and ASD; 4) Establish age-related variables for use across Projects, including a biomarker of brain age and documentation of age of ASD diagnosis; 5) Manage scheduling of participants for all Projects. 6) Support retention of participants and monitor progress through Projects; 7) Monitor risks related to suicidality and other adverse events, and 8) To collaborate with other Cores and Projects. The Core will enroll 200 autistic and 100 non-autistic 18- to 65-year-old adults (>50 in each group with a recent history of suicidal ideation or behaviors [SI/SB], defined as active SI/SB within the past four months). We anticipate needing to consent and assess approximately 100 additional individuals to account for those who do not meet inclusion criteria. Those meeting study inclusion criteria will be invited to participate in all three Projects. Our team has consistently met recruitment goals for numerous NIH-funded studies of autistic adults, we have active partnerships with several registries for autistic and non-autistic adults, and we will collaborate with the Dissemination and Partnership Core to enhance our inclusion of autistic adults from groups that have been marginalized. The Clinical Core organizes the extensive recruitment effort to assure the Projects meet their targeted enrollments and complete their proposed studies, while assuring all the data mandated by the ACE funding mechanism is collected. The centralization of these services in a Core combines the recruitment resources that would otherwise be distributed across Projects, thereby reducing the redundancy and inefficiency that would occur if each Project had to perform these efforts individually. Research-reliable Clinical Core staff will conduct ASD diagnostic and cognitive assessments using the tools outlined in the RFA; this also creates an efficient process and supports the collaboration of investigators new to autism in this ACE center. Finally, Clinical Core staff are highly experienced in the assessment of SI/SB and psychiatric diagnoses and will monitor for suicide-related risks.

临床核心摘要 临床核心的目的是1）：管理招聘活动并同意并注册匹兹堡 ACE队列参加这三个项目。我们将优先考虑个人的参与 传统上在ASD研究（例如种族/种族，LGBTQIA+，女性和ASD诊断ASD中的ASD少数 成年）; 2）：管理，评分和输入ASD诊断评估的数据，并管理所有RFA- 必需和中央范围的表型措施； 3）应用新颖的后验诊断概率（PPOD） 估计精神诊断和ASD的存在的索引； 4）建立与年龄相关的变量供使用 在整个项目中，包括脑年龄的生物标志物以及ASD诊断年龄的记录； 5）管理 为所有项目的参与者安排。 6）支持保留参与者并通过 项目； 7）监控与自杀性和其他不良事件有关的风险，以及8）与其他合作 核心和项目。核心将注册200名自闭症和100个非自动主义18至65岁的成年人（> 50英寸 每个具有自杀意念或行为[Si/SB]的近期历史的组，定义为活性SI/SB 过去四个月）。我们预计需要同意并评估大约100个个人 说明那些不符合纳入标准的人。那些会议研究的纳入标准将被邀请 参加所有三个项目。我们的团队一直为众多NIH资助而实现招聘目标 研究自闭症成年人，我们与几个自闭症和非自闭症成年人的注册表建立了积极的伙伴关系， 我们将与传播和伙伴关系核心合作，以增强我们的自闭症成年人的包含 来自被边缘化的群体。临床核心组织了广泛的招聘工作 确保项目符合其目标入学率并完成拟议的研究，同时确保所有 收集了由ACE融资机制规定的数据。这些服务的集中化核心 结合招募资源，否则将在项目中分发，从而减少 如果每个项目都必须单独执行这些努力，将会发生冗余和效率低下。 可靠的可靠临床核心人员将使用工具进行ASD诊断和认知评估 在RFA中概述；这也创造了一个有效的过程，并支持新手的调查人员合作 在这个王牌中心的自闭症。最后，临床核心人员在评估SI/SB和 精神科诊断，将监测与自杀有关的风险。