Mental Health in Autistic Adults: An RDoC Approach

成人自闭症患者的心理健康：RDoC 方法

• 批准号: 10698092
• 负责人: BENJAMIN L HANDEN
• 金额: $ 54.15万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-06 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10698092
• 关键词: Adherence; Adult; Adverse event; Age; Aging; Algorithms; Anxiety; Appointment; Attention deficit hyperactivity disorder; Biological Markers; Brain; Clinical; Clinical Data; Collaborations; Communication; Communities; Consent; Crisis Intervention; Data; Diagnosis; Diagnostic; Differential Diagnosis; Dimensions; Documentation; Elderly; Electronic Mail; Enrollment; Ensure; Ethnic Origin; Feeling suicidal; Female; Funding; Funding Mechanisms; Goals; Grant; Health Personnel; Individual; Intellectual functioning disability; Lead; Machine Learning; Measures; Mental Depression; Mental Health; Methods; Minority; Monitor; Newsletter; Participant; Personality Disorders; Persons; Phenotype; Probability; Procedures; Process; Productivity; Protocols documentation; Psychiatric Diagnosis; Race; Recording of previous events; Recruitment Activity; Registries; Reporting; Research; Research Domain Criteria; Research Personnel; Research Project Grants; Resources; Risk; Rural; Safety; Schedule; Services; Structure; Suicide; Symptoms; System; Time; Training; Uncertainty; United States National Institutes of Health; Update; Visit; adult with autism spectrum disorder; age related; autism spectrum disorder; autistic; cognitive testing; cohort; ethnic identity; experience; human old age (65+); inclusion criteria; indexing; innovation; marginalization; marginalized population; meetings; novel; participant retention; phenotypic data; predictive modeling; programs; racial identity; recruit; response; satisfaction; screening; service intervention; sex; success; suicidal; suicidal behavior; suicidal risk; theories; tool

Clinical Core Abstract The purpose of the Clinical Core is 1): To manage recruitment activities and consent and enroll a Pittsburgh ACE Cohort for participation in the three Projects. We will prioritize increased participation by individuals traditionally minoritized in ASD research (e.g., race/ethnicity, LGBTQIA+, females, and diagnosis of ASD in adulthood); 2): Administer, score, and enter data for ASD diagnostic assessments and administer all RFA- required and center-wide phenotypic measures; 3) Apply a novel posterior probability of diagnosis (PPOD) index to estimate the presence of psychiatric diagnoses and ASD; 4) Establish age-related variables for use across Projects, including a biomarker of brain age and documentation of age of ASD diagnosis; 5) Manage scheduling of participants for all Projects. 6) Support retention of participants and monitor progress through Projects; 7) Monitor risks related to suicidality and other adverse events, and 8) To collaborate with other Cores and Projects. The Core will enroll 200 autistic and 100 non-autistic 18- to 65-year-old adults (>50 in each group with a recent history of suicidal ideation or behaviors [SI/SB], defined as active SI/SB within the past four months). We anticipate needing to consent and assess approximately 100 additional individuals to account for those who do not meet inclusion criteria. Those meeting study inclusion criteria will be invited to participate in all three Projects. Our team has consistently met recruitment goals for numerous NIH-funded studies of autistic adults, we have active partnerships with several registries for autistic and non-autistic adults, and we will collaborate with the Dissemination and Partnership Core to enhance our inclusion of autistic adults from groups that have been marginalized. The Clinical Core organizes the extensive recruitment effort to assure the Projects meet their targeted enrollments and complete their proposed studies, while assuring all the data mandated by the ACE funding mechanism is collected. The centralization of these services in a Core combines the recruitment resources that would otherwise be distributed across Projects, thereby reducing the redundancy and inefficiency that would occur if each Project had to perform these efforts individually. Research-reliable Clinical Core staff will conduct ASD diagnostic and cognitive assessments using the tools outlined in the RFA; this also creates an efficient process and supports the collaboration of investigators new to autism in this ACE center. Finally, Clinical Core staff are highly experienced in the assessment of SI/SB and psychiatric diagnoses and will monitor for suicide-related risks.

临床核心摘要 临床核心的目的是1）：管理招募活动，同意并招募匹兹堡 ACE队列参与三个项目。我们将优先考虑增加个人的参与 传统上在ASD研究中被少数化（例如，种族/民族、LGBTQIA+、女性和ASD诊断， 成年期）; 2）：管理、评分和输入ASD诊断评估数据，并管理所有RFA- 所需的和中心范围的表型指标; 3）应用新的诊断后验概率（PPOD） 估计精神病诊断和ASD存在的指数; 4）建立年龄相关变量以供使用 跨项目，包括大脑年龄的生物标志物和ASD诊断年龄的记录; 5）管理 安排所有项目的参与者。6)支持留住参与者并通过以下方式监测进展情况 项目; 7）监测与自杀和其他不良事件相关的风险，以及8）与其他人合作 核心和项目。核心将招募200名自闭症患者和100名非自闭症患者，年龄在18至65岁之间（>50岁）。 各组近期有自杀意念或行为[SI/SB]史，定义为 过去四个月）。我们预计还需要同意和评估大约100名个人， 考虑不符合入选标准的患者。将邀请符合研究入选标准的患者 参与这三个项目。我们的团队一直满足许多NIH资助的招聘目标 研究自闭症成年人，我们与几个自闭症和非自闭症成年人登记处建立了积极的合作关系， 我们将与传播和伙伴关系核心合作，以加强我们对自闭症成年人的包容 被边缘化的群体。临床核心组织广泛的招聘工作， 确保项目达到目标入学率并完成拟议的研究，同时确保所有 收集ACE供资机制规定的数据。将这些服务集中在核心 将原本分布在各个项目中的招聘资源结合起来，从而减少 如果每个项目必须单独执行这些工作，则会出现冗余和低效率。 研究可靠的临床核心工作人员将使用这些工具进行ASD诊断和认知评估 这也创造了一个有效的过程，并支持新的研究者的合作， 自闭症患者最后，临床核心人员在SI/SB评估方面经验丰富， 精神病诊断，并将监测与自杀有关的风险。