Plasmon-Enhanced Chiroptical Biosensors

等离激元增强手性光学生物传感器

• 批准号: EP/K034936/1
• 负责人: M Kadodwala
• 金额: $ 99.35万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FK034936%2F1
• 关键词: Plasmon; Enhanced; Chiroptical; Biosensors

Polarimetry has been used for over two hundred years to detect and characterise inherently chiral biomolecules andbiomaterials. In this proposal we will use a 21st century "re-boot" of polarimetry, which uses chiral evanescentelectromagnetic fields produced by chiral plasmonic nanostructures instead of circularly polarised light, to achieve (sub)picogram detection / characterisation of an analyte. We will develop biosensors that use plasmon-enhanced polarimetry,superpolarimetry, to both transduce binding events and provide structural information on the bound analyte. These sensorswill provide label-free detection of analytes, and will be applied in an array-based format to the analysis of complex biofluidswhile providing fundamental information on nanoscale chiroptical phenomena.The vision at the heart of our research is the creation of a new sensor platform based on plasmon-enhanced chiropticaleffects. In addition to this goal, we expect that we will obtain fundamental advances in the understanding of chiropticalbehavior. In the course of our research we will develop new high-throughput methods to fabricate sensors, opening uppotential real-world applications of superpolarimetry. Taken together, our expectation is that the proposed research willprovide the foundational research required to bridge the gap between fundamental discovery and a widely useable sensorplatform.

偏振法用于检测和表征固有手性生物分子和生物材料已有200多年的历史。在本提案中，我们将使用21世纪的“重新启动”偏振法，它使用手性等离子体纳米结构产生的手性倏逝电磁场而不是圆偏振光，来实现分析物的（亚）皮克图检测/表征。我们将开发使用等离子体增强偏振法、超偏振法的生物传感器，以转导结合事件并提供结合分析物的结构信息。这些传感器将提供分析物的无标签检测，并将以阵列形式应用于复杂生物流体的分析，同时提供纳米级热带现象的基本信息。我们研究的核心愿景是建立一个基于等离子体增强的神经效应的新传感器平台。除了这个目标之外，我们期望我们将在对黑猩猩行为的理解上取得根本性的进展。在我们的研究过程中，我们将开发新的高通量方法来制造传感器，开辟超偏振法在现实世界中的潜在应用。综上所述，我们的期望是，拟议的研究将提供必要的基础研究，以弥合基础发现和广泛使用的传感器平台之间的差距。

项目成果

Chiral Plasmonic Fields Probe Structural Order of Biointerfaces.

• DOI: 10.1021/jacs.8b03634
• 发表时间: 2018-07-11
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Kelly C;Tullius R;Lapthorn AJ;Gadegaard N;Cooke G;Barron LD;Karimullah AS;Rotello VM;Kadodwala M
• 通讯作者: Kadodwala M

Controlling Metamaterial Transparency with Superchiral Fields

• DOI: 10.1021/acsphotonics.7b01071
• 发表时间: 2018-02-01
• 期刊: ACS PHOTONICS
• 影响因子: 7
• 作者: Kelly, Christopher;Khorashad, Larousse Khosravi;Kadodwala, Malcolm
• 通讯作者: Kadodwala, Malcolm

Spatial control of chemical processes on nanostructures through nano-localized water heating.

• DOI: 10.1038/ncomms10946
• 发表时间: 2016-03-10
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Jack C;Karimullah AS;Tullius R;Khorashad LK;Rodier M;Fitzpatrick B;Barron LD;Gadegaard N;Lapthorn AJ;Rotello VM;Cooke G;Govorov AO;Kadodwala M
• 通讯作者: Kadodwala M

Superchiral Plasmonic Phase Sensitivity for Fingerprinting of Protein Interface Structure.

• DOI: 10.1021/acsnano.7b04698
• 发表时间: 2017-12-26
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Tullius R;Platt GW;Khosravi Khorashad L;Gadegaard N;Lapthorn AJ;Rotello VM;Cooke G;Barron LD;Govorov AO;Karimullah AS;Kadodwala M
• 通讯作者: Kadodwala M