Meta-Smart: Merging de novo designed biomolecules with plasmonic metamaterials for new technologies

Meta-Smart：将从头设计的生物分子与等离激元超材料相结合，以实现新技术

• 批准号: EP/S029168/1
• 负责人: M Kadodwala
• 金额: $ 130.24万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FS029168%2F1
• 关键词: Meta; Smart; Merging; de; novo

We live in a world in which individuals have unprecedented access to data on their environment, health and wellbeing. This ranges from information provided by fitness bands, to the energy smart meters that are found in every home. However, our current capabilities pale when compared to the sensory abilities found in Nature. For, instance no technology has been developed that can rival the ability of a spaniel for sniffing out contraband. To replicate Nature's capabilities to detect a vast array of stimuli with ultra-sensitivity is still in the realms of science fiction. In natural sensory systems, typically a change in molecular structure (in a receptor molecule) induced by a stimulus, is detected and propagated by a complex biological architecture. While chemists can mimic the function of receptor molecules, it is the functionality of complex biological component to convert and propagate this structural change into a useable signal that is a challenge to replicate. We propose a new concept Meta-Smart, where the initial molecular sensing event is retained, but the functionality of the biological architecture is replicated by an engineered nanofabricated structure (metamaterial). In effect the metamaterial amplifies the chemical signal, converting it into a readily detectible response. Taking inspiration from Nature, the property of chirality will be utilised to effectively unify biomacromolecular and metamaterial properties. To demonstrate the transformative potential of the Meta-Smart concept we will build bio-inspired chemo- and photosensing devices.

我们生活在一个个人可以前所未有地获得有关其环境、健康和福祉的数据的世界。这包括健身带提供的信息，以及每个家庭都可以找到的智能能源电表。然而，与自然界中发现的感官能力相比，我们目前的能力相形见绌。例如，目前还没有一种技术能与西班牙猎犬的嗅出违禁品的能力相媲美。复制自然的能力，以超灵敏度检测大量的刺激仍然是在科幻小说的领域。在自然感觉系统中，通常由刺激诱导的分子结构（受体分子）的变化由复杂的生物结构检测和传播。虽然化学家可以模拟受体分子的功能，但复杂生物成分的功能是将这种结构变化转化并传播为可用的信号，这是复制的挑战。我们提出了一个新的概念Meta-Smart，其中保留了最初的分子传感事件，但生物体系结构的功能由工程纳米制造结构（超材料）复制。实际上，超材料放大了化学信号，将其转换为易于检测的响应。从大自然中获得灵感，手性的性质将被用来有效地统一生物大分子和超材料的性质。为了展示Meta-Smart概念的变革潜力，我们将构建生物启发的化学和光敏设备。

项目成果

Chiral Metafilms and Surface Enhanced Raman Scattering for Enantiomeric Discrimination of Helicoid Nanoparticles

• DOI: 10.1002/adom.202202991
• 发表时间: 2022-12
• 期刊: Advanced Optical Materials
• 影响因子: 9
• 作者: M. Kartau;A. Skvortsova;Victor Tabouillot;Shailendra K. Chaubey;Polina Bainova;Rahul Kumar;V. Burtsev;V. Svorcik;N. Gadegaard;Sang Won Im;M. Urbanova;O. Lyutakov;M. Kadodwala;A. Karimullah

Coupling of plasmonic hot spots with shurikens for superchiral SERS-based enantiomer recognition.

• DOI: 10.1039/d3nh00008g
• 发表时间: 2022-08
• 期刊: Nanoscale horizons
• 影响因子: 9.7
• 作者: O. Guselnikova;R. Elashnikov;V. Svorcik;M. Kartau;C. Gilroy;N. Gadegaard;M. Kadodwala;A. Karimullah;O. Lyutakov

Coupling of Plasmonic Hot Spots with Shurikens for Superchiral SERS-based Enantiomer Recognition

等离子体热点与手里剑的耦合用于基于超手性 SERS 的对映体识别

• DOI: 10.48550/arxiv.2208.05454
• 发表时间: 2022
• 作者: Guselnikova O

Controlling the symmetry of inorganic ionic nanofilms with optical chirality.

控制具有光学手性的无机离子纳米膜的对称性。

• DOI: 10.1038/s41467-020-18869-9
• 发表时间: 2020-10-14
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Kelly C;MacLaren DA;McKay K;McFarlane A;Karimullah AS;Gadegaard N;Barron LD;Franke-Arnold S;Crimin F;Götte JB;Barnett SM;Kadodwala M
• 通讯作者: Kadodwala M

Attomole enantiomeric discrimination of small molecules using an achiral SERS reporter and chiral plasmonics

使用非手性 SERS 报告基因和手性等离子体激元对小分子进行 Attomole 对映体区分

• DOI: 10.48550/arxiv.2310.09083
• 发表时间: 2023
• 作者: Chaubeya S