RELATIONSHIP BETWEEN MOUSE SPERM MORPHOLOGY AND MOTILITY
小鼠精子形态与活力之间的关系
基本信息
- 批准号:3439663
- 负责人:
- 金额:$ 9.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1989
- 资助国家:美国
- 起止时间:1989-04-01 至 1993-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
While both sperm motility and morphology are usually evaluated as
indications of fertility, their relative importance in fertility
is unknown. In many cases of infertility abnormal sperm morphology
is correlated with poor motility. Sperm morphology has been shown
to be genetically controlled and different strains of mice show
characteristic differences in the size and shape of the sperm head,
as well as different levels of morphologically abnormal sperm.
These characteristics of sperm morphology are usually established
between 6 and 10 wks. of age and are maintained until old age. No
systematic studies on the influence of genotype on the pattern of
sperm motility have been reported and the timing of the acquisition
of normal patterns of sperm motility is also unknown. Many mutant
genes lead to infertility in male but not female mice. These
mutant mice provide the opportunity to study the characteristics
of fertile and infertile sperm. This study has three aims. The
first is to investigate differences in the motility patterns of
normal sperm of different sizes and shapes from different strains
of mice. These data should enable us to determine the correlation
between morphology and motility. They will also provide the
starting point for the analysis of the genetic influence on sperm
motility. The second goal is to compare the swimming
characteristics of morphologically abnormal sperm to normal sperm
from the same animal. These studies will demonstrate whether
certain types of morphological alterations are associated with
motility impairment. The third goal is to determine the morphology
and motility of sperm from mutant males that have unexplained
infertility. The comparison of morphology and motility
characteristics of infertile and fertile males may suggest which
characteristics of sperm are most essential for fertility.
虽然精子活力和形态通常被评估为
生育率指标,其在生育率中的相对重要性
不明 在许多不育症中精子形态异常
与运动性差有关 精子形态学已经证明
不同品系的老鼠显示
精子头部大小和形状的特征差异,
以及不同程度的精子形态异常。
精子形态的这些特征通常是建立在
在6至10周龄之间,并维持至老年。 没有
系统研究了基因型对遗传方式的影响,
据报道,精子活力和获得精子的时间
精子活动力的正常模式也是未知的。 多的变异
基因导致雄性小鼠不育,而不是雌性小鼠。 这些
突变小鼠提供了研究
有生育能力和无生育能力的精子。 本研究有三个目的。 的
第一个是研究不同的运动模式,
来自不同品系的不同大小和形状的正常精子
对小鼠 这些数据应该能让我们确定
形态学和运动性之间的联系 他们还将提供
分析基因对精子影响的起点
能动性 第二个目标是比较游泳
形态异常精子与正常精子的特征
来自同一种动物。 这些研究将证明,
某些类型的形态学改变与
运动障碍 第三个目标是确定形态
和精子的活力,
不孕 形态学和运动学的比较
不育和生育男性的特征可能表明,
精子的特征对生育能力至关重要。
项目成果
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{{ truncateString('BETSY PEITZ', 18)}}的其他基金
SEMINAL VESICLES AND SPERM MOTILITY IN MURID SPECIES
鼠科物种的精囊和精子活力
- 批准号:
3439503 - 财政年份:1986
- 资助金额:
$ 9.87万 - 项目类别:
ROLE OF THE SEMINAL VESICLES IN FERTILITY IN THE HOUSE MICE
精囊在家鼠生育能力中的作用
- 批准号:
3915695 - 财政年份:
- 资助金额:
$ 9.87万 - 项目类别:
ROLE OF THE SEMINAL VESICLES IN FERTILITY IN THE HOUSE MICE
精囊在家鼠生育能力中的作用
- 批准号:
3936804 - 财政年份:
- 资助金额:
$ 9.87万 - 项目类别:
ROLE OF THE SEMINAL VESICLES IN FERTILITY IN THE HOUSE MICE
精囊在家鼠生育能力中的作用
- 批准号:
3877323 - 财政年份:
- 资助金额:
$ 9.87万 - 项目类别:
ROLE OF THE SEMINAL VESICLES IN FERTILITY IN THE HOUSE MICE
精囊在家鼠生育能力中的作用
- 批准号:
3856311 - 财政年份:
- 资助金额:
$ 9.87万 - 项目类别:
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