Genetic strain differences for strength training trainablitiy in rats and its application for understanding of muscle hypertrophy

众所周知，力量训练的可训练性因个体差异而异。在本研究中，我们首次建立了大鼠力量训练模型，并发现力量训练存在遗传应变差异。力量训练使SD大鼠出现明显的肌肉肥大，而Wistar大鼠则无明显变化。我们还发现，不同肌肉收缩模式(等长收缩和等长收缩)的混合和低频电刺激对力量训练反应低的Wistar品系的肌肉肥大是有效的。由于电刺激已被用于康复，低频电刺激不仅对低反应者有用，对受伤运动员也是有用的。

It has been well recognized that trainability for strength training varies depending on individual difference. In this study, we originally developed strength training model for rats and found that genetic strain difference exist for strength training. Sprague Dawley rat shows significant muscle hypertrophy with strength training but Wistar rats did not. We also found that mixture of different muscle contraction modes (isometric contractions and isometric contractions) and low frequency electrical stimulation are effective for muscle hypertrophy in Wistar strain with low response for strength training. Since electrical stimulation has been used in rehabilitation, low frequency electrical stimulation will be useful not only for low responder but for injured athletes.