Genetic strain differences for strength training trainablitiy in rats and its application for understanding of muscle hypertrophy

大鼠力量训练可训练性的遗传应变差异及其在理解肌肉肥大中的应用

• 批准号: 23500788
• 负责人: NAKAZATO Koichi
• 金额: $ 3.24万
• 依托单位: Nippon Sport Science University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500788/
• 关键词: 筋肥大; 動物モデル; ラット; 個体差; タンパク質合成; タンパク質分解; 種特異性; 筋タンパク質合成; トレーニング; 系統種

It has been well recognized that trainability for strength training varies depending on individual difference. In this study, we originally developed strength training model for rats and found that genetic strain difference exist for strength training. Sprague Dawley rat shows significant muscle hypertrophy with strength training but Wistar rats did not. We also found that mixture of different muscle contraction modes (isometric contractions and isometric contractions) and low frequency electrical stimulation are effective for muscle hypertrophy in Wistar strain with low response for strength training. Since electrical stimulation has been used in rehabilitation, low frequency electrical stimulation will be useful not only for low responder but for injured athletes.

人们已经充分认识到，力量训练的可训练性取决于个体差异。本研究首次建立了大鼠力量训练模型，发现力量训练存在遗传应变差异。道利大鼠在力量训练中表现出明显的肌肉肥大，而Wistar大鼠则无此现象。我们还发现，不同的肌肉收缩模式（等长收缩和等长收缩）的混合和低频电刺激是有效的肌肉肥大的Wistar品系与低反应的力量训练。由于电刺激已用于康复，因此低频电刺激不仅对低反应者有用，而且对受伤的运动员也有用。

项目成果

Effect of intermittent low-frequency electrical stimulation on the rat gastrocnemius muscle.

• DOI: 10.1155/2013/480620
• 发表时间: 2013
• 期刊: BioMed research international
• 作者: Tsutaki A;Ogasawara R;Kobayashi K;Lee K;Kouzaki K;Nakazato K
• 通讯作者: Nakazato K

間欠的低周波電気刺激によるタンパク質合成関連シグナルについての検討

间歇低频电刺激蛋白质合成相关信号的研究

• 发表时间: 2013
• 作者: 蔦木 新;小笠原 理紀;李 基赫;鴻崎 香里奈;小林 幸次;中里 浩一
• 通讯作者: 中里 浩一

Genetic Strain-Dependent Protein Metabolism and Muscle Hypertrophy Under Chronic Isometric Training in Rat Gastrocnemius Muscle

• DOI: 10.33549/physiolres.932312
• 发表时间: 2012-01-01
• 期刊: PHYSIOLOGICAL RESEARCH
• 影响因子: 2.1
• 作者: Kobayashi, K.;Ogasawara, R.;Nakazato, K.
• 通讯作者: Nakazato, K.