Genetic strain differences for strength training trainablitiy in rats and its application for understanding of muscle hypertrophy

众所周知，力量训练的可训练性因个体差异而异。在本研究中，我们首次建立了大鼠力量训练模型，发现力量训练存在遗传品系差异。Sprague Dawley大鼠在力量训练后表现出明显的肌肉肥大，而Wistar大鼠则没有。我们还发现，不同的肌肉收缩模式（等长收缩和等长收缩）和低频电刺激的混合可以有效地治疗Wistar劳损肌肉肥大，而力量训练的反应较低。由于电刺激已用于康复，低频电刺激不仅对低反应者有用，而且对受伤的运动员也有用。

It has been well recognized that trainability for strength training varies depending on individual difference. In this study, we originally developed strength training model for rats and found that genetic strain difference exist for strength training. Sprague Dawley rat shows significant muscle hypertrophy with strength training but Wistar rats did not. We also found that mixture of different muscle contraction modes (isometric contractions and isometric contractions) and low frequency electrical stimulation are effective for muscle hypertrophy in Wistar strain with low response for strength training. Since electrical stimulation has been used in rehabilitation, low frequency electrical stimulation will be useful not only for low responder but for injured athletes.