RECENT ADVANCES IN THE BIOMEDICAL SIGNIFICANCE OF TRH

TRH广泛分布于中枢神经系统 与神经元功能中的作用一致， 调节垂体激素分泌。 事实上， 最近在人类和其他神经生物学研究中的证据表明， 动物表明，这种物质是一种神经递质， 哺乳动物中枢神经系统中的神经调质， 生物医学意义 这次会议的目的是把知识 从一些不同领域的显著进步中衍生出来， 在过去五年中， 这种三肽酰胺的生物医学作用。 已经确定 TRH是核糖体的产物而不是酶的产物， 而TRH前体本身就是 一个全新的肽类家族。 此外，本发明还 在理解这些因素方面已经取得了重要进展， 调节TRH及其类似物与受体的结合。 的 促甲状腺激素释放激素（TRH）对大鼠心肌细胞肌醇第二信使系统的影响 垂体提供了一个神经化学模型，为广泛的 CNS作用归因于该肽。 TRH共定位于 脑干神经元与另一种神经肽，P物质， 一种经典的神经递质5-羟色胺， 认识到所有这些物质的分泌可能是 密切相关。 最后，有重要的临床 研究指出TRH在以下疾病中可能的治疗作用： 肌萎缩侧索硬化症（ALS）、脊髓创伤和 心血管休克 这个由纽约学院主办的会议 科学将吸引科学家形成广泛的 每个学科都涉及TRH生物学的不同方面。 作为一个论坛，它将汇集来自不同领域的调查人员， 背景包括分子生物学，神经内分泌学， 药理学，肽化学，神经生物学，神经化学， 酶学和临床神经学。 本次会议将提供 一种将有关TRH的新信息整合到 多学科方式，确定具体领域， 神经生物学需要进一步研究和促进合作 不同学科的科学家之间的研究。

TRH has a widespread distribution throughout the CNS consistent with a role in neuronal function in addition to regulation of pituitary hormone secretion. Indeed, much evidence from recent neurobiologic studies in man and other animals suggests that this substance is a neurotransmitter or neuromodulator in the mammalian CNS with potential biomedical implication. The purpose of this conference is to coalesce the knowledge derived from the remarkable advance in a number of different areas that have taken place during the past five years in the biomedical role of this tripeptide amide. It has been established that TRH is the product of ribosomal and not enzymatic biosynthesis and that the TRH precursor itself is the progenitor of a whole new family of peptides in addition to TRH. Further, important advances have been made in understanding the factors regulating the binding of TRH and its analogs to receptors. The effects of TRH on inositol second messenger systems in the pituitary provide a neurochemical model for the wide range of CNS action attributed to this peptide. TRH is co-localized in brain stem neurons with another neural peptide, substance P, and a classical neurotransmitter, 5 hydroxytryptamine, and it is now recognized that the secretion of all these substances may be intimately related. Finally, there have been important clinical studies pointing to a possible therapeutic role for TRH in amyotrophic lateral sclerosis (ALS), spinal trauma, and cardiovascular shock. This proposed conference sponsored by the New York Academy of Sciences will attract scientists form a wide range of disciplines, each involved in different aspects of TRH biology. As a forum, it will bring together investigators form diverse backgrounds including molecular biology, neuroendocrinology, pharmacology, peptide chemistry, neurobiology, neurochemistry, enzymology, and clinical neurology. This conference will provide a means of integrating new information on TRH in a multidisciplinary fashion, identifying specific areas of neurobiology requiring further study and fostering collaborative studies between scientists of separate disciplines.