Integrated Program in Endocrinology Translational Postdoctoral Training Program

内分泌学综合项目转化博士后培训项目

• 批准号: 10390410
• 负责人: IAN M. BIRD
• 金额: $ 32.91万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10390410
• 关键词: Endocrinology; Training Programs; post-doctoral training; programs

Abstract. The rate of progress in understanding the basis for reproductive health and disease is breathtaking, accelerated ever further by constant advances in cellular and molecular techniques. Nonetheless, research in traditional academic departments and research in clinical departments often does not overlap. As such, the PhD trained in a purely academic environment will remain unexposed to the clinical mindset and practices and so fail to pursue translational goals, while the clinician Fellow is well aware of the clinical problem and by definition focused on the human itself, but may be less aware of recent conceptual and methodologic advances available to investigate clinically derived research questions. As PA-18-403 RFA states, “past studies have shown that health professional trainees who train in programs with postdoctoral researchers who have intensive research backgrounds are more likely to apply for and receive subsequent research grant support”. To that end, the goal of this proposal is simple - to provide for the PhD and MD Fellow a combined and integrated immersion experience in a cutting edge cross campus research program that is in itself embedded in and focused upon a more clinical environment where health and disease is the primary consideration, and to then promote the use of nonhuman primate and human derived models in MD or PhD Fellowship projects lead by MD/DVM/PhD Faculty of combined clinical and traditional training backgrounds. The campus home for this program will be the integrated Program in Endocrinology (iPEnd), which was founded in 2016 to foster and promote collaboration focused on fetal development and the compromised adult outcomes of adverse pregnancy. We propose here that iPEnd also offers a vibrant interdisciplinary and multidisciplinary environment comprised of MD, PhD and DVM trained faculty with which both MD and PhD Postdoctoral Fellows could train together to enter the world of translational research. Such a blended training environment is very much needed if we are to maintain a future pool of interdisciplinary translational research team members intellectually and professionally ready to pursue the goals of NICHD to improve reproductive health and outcomes. Another consideration by NIH is that trainees do not go on to future independent success by simple exposure to ‘good science’ alone. Indeed, both Trainees and Trainers need support and professional education to ensure the best outcomes. To that end, our proposed training includes a deep immersion in higher level research training typical of many T32 programs at this time, but we aim to go far beyond to include the evidence based 8 core competencies for Postdoctoral trainees combined with added Mentee and Mentor training and the complimentary Professional Development Resources in order to achieve the rich blended training environment so strongly recommended by NIH. We believe iPEnd is ready to promote the concepts of the interdisciplinary and multidisciplinary ‘Translational Workforce’ through the proposed Training Program, operating within first class campus environment geared for basic but increasingly supportive of translational research. On that basis, we submit this application.

抽象的。在了解生殖健康和疾病基础方面的进展速度是惊人的， 细胞和分子技术的不断进步进一步加速了这一进程。尽管如此，研究 传统的学术部门和临床部门的研究往往不重叠。因此，博士学位 在纯粹的学术环境中接受培训的人将无法接触临床思维和实践，因此会失败 追求转化目标，而临床医生研究员很清楚临床问题并且根据定义 关注人类本身，但可能不太了解最新的概念和方法进展 调查临床衍生的研究问题。正如 PA-18-403 RFA 所述，“过去的研究表明 与进行深入研究的博士后研究人员一起接受培训的卫生专业实习生 有背景的人更有可能申请并获得后续研究资助支持”。为此，目标 该提案的目的很简单 - 为博士和医学博士研究员提供组合和综合的沉浸式体验 尖端跨校园研究项目的经验，该项目本身嵌入并专注于 更多以健康和疾病为首要考虑的临床环境，进而推广使用 由 MD/DVM/PhD 领导的医学博士或博士奖学金项目中的非人类灵长类动物和人类衍生模型 具有临床和传统培训背景相结合的教师队伍。该计划的校园之家将是 内分泌学综合项目 (iPEnd)，成立于 2016 年，旨在促进和促进合作 重点关注胎儿发育和不良妊娠对成人结局的影响。我们在这里提议 iPEnd 还提供了一个充满活力的跨学科和多学科环境，由医学博士、博士和 DVM 训练有素的教师，MD 和博士博士后研究员可以一起接受培训，进入医学世界 转化研究。如果我们要维持未来，那么这样的混合培训环境是非常需要的 跨学科转化研究团队成员在智力和专业上都做好了追求的准备 NICHD 的目标是改善生殖健康和结果。 NIH 的另一个考虑因素是受训者 不要仅仅通过简单地接触“好的科学”来获得未来的独立成功。确实，两位实习生 培训师需要支持和专业教育，以确保取得最佳成果。为此，我们建议 培训包括深度沉浸在目前许多 T32 项目典型的更高水平的研究培训中， 但我们的目标远不止于此，包括博士后培训生的 8 项基于证据的核心能力 结合新增的学员和导师培训以及免费的专业发展资源 以实现 NIH 强烈推荐的丰富的混合训练环境。我们相信 iPEnd 准备通过以下方式推广跨学科和多学科“转化劳动力”的概念 拟议的培训计划，在一流的校园环境中进行，适合基础但 越来越多的人支持转化研究。在此基础上，我们提交此申请。