Research Training in Endocrinology and Metabolism

内分泌学和代谢研究培训

• 批准号: 10627311
• 负责人: Laura C Alonso
• 金额: $ 18.95万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627311
• 关键词: Endocrinology; Research Training

PROJECT SUMMARY This proposed postdoctoral training program (2 fellows/year, 2-year program) in endocrinology and metabolism will provide comprehensive research training for individuals with a serious commitment to a career at the interface of biomedical research and endocrine disorders. Metabolic diseases represent significant health burden in the US; advances in the pathophysiology of these diseases are required to improve diagnostics, therapeutics and health outcomes. Weill Cornell Medicine (WCM) is experiencing accelerating growth in clinical and biomedical research activities, due to the singular emphasis on developing medical research over the past decade during the Deanships of Dr. Laurie Glimcher and Dr. Augustine Choi. Investment in the Department of Medicine and the Division of Endocrinology, Diabetes and Metabolism has been significant. Dr. Anthony Hollenberg, a prominent endocrinologist and thyroid biologist, was recruited to Chair the Department of Medicine in 2018; his support has catapulted metabolic research to a high priority on campus, resulting in recruitments and significant internal and external resources. Dr. Laura Alonso, islet biologist and PD on this proposal, was recruited in 2019 to be Chief of the Endocrinology Division and Director of the Weill Center for Metabolic Health, a newly assembled research group on campus focused on metabolism, with 45+ faculty and 150+ members. Our proposed T32 leadership team also includes Dr. Julianne Imperato-McGinley, renowned endocrinologist, prior Division Chief and current Director of the Weill Cornell CTSC. However, the impetus for this proposal is not the leadership team, but rather the incredible trainees that have been finding a path to academic medicine even without T32 support. Three clinical endocrine fellows in the past 10 years managed to obtain K08 awards and are currently leading successful academic research careers, despite the lack of an available T32; one of our current 2nd year fellows elected to pursue a 3rd year of research training even though our program has been advertised as a 2-year clinical program, and both of the incoming clinical fellows for 2022 are outstanding researchers, one with a PhD from Cal Tech and the other with a first author Nature Medicine paper in islet biology, mentored by one of our faculty preceptors (Dr. Lo). We have hand-picked a top team of research Preceptors, and designed a comprehensive didactic training plan with wrap-around mentoring to guide trainees through eventual R01 submission. Our recruitment plan is thorough and has a strong emphasis towards enrolling top URM candidates. We propose a tri- institutional (WCM, MSKCC and RU), rigorous multidisciplinary T32 to enroll 2 postdoctoral MD or PhD trainees annually for 2 years training duration each. The leaders of this training program will work with the utmost enthusiasm and energy to ensure that our trainees reach their potential to excel and contribute significantly to the academic endocrine community for years to come.

项目概要 该拟议的内分泌学博士后培训计划（2名研究员/年，为期2年） 新陈代谢将为认真致力于新陈代谢的个人提供全面的研究培训 生物医学研究和内分泌疾病交叉领域的职业生涯。代谢性疾病代表 美国的重大健康负担；这些疾病的病理生理学的进展需要 改善诊断、治疗和健康结果。威尔康奈尔医学 (WCM) 正在经历 由于特别重视临床和生物医学研究活动的加速增长 在过去的十年里，在 Laurie Glimcher 博士和 Dr. Laurie Glimcher 博士担任院长期间，我们致力于发展医学研究。 奥古斯丁·崔.医学部和内分泌科、糖尿病科的投资 新陈代谢也很重要。安东尼·霍伦伯格博士，著名内分泌学家和甲状腺专家 生物学家，2018 年被聘为医学系主任；他的支持促进了新陈代谢 研究在校园内得到高度重视，从而导致招聘和重要的内部和外部 资源。胰岛生物学家兼该提案的负责人 Laura Alonso 博士于 2019 年被聘为首席科学家 内分泌科和威尔代谢健康中心主任，这是一个新组建的 校园研究小组专注于新陈代谢，拥有 45 多名教职人员和 150 多名成员。我们提出的 T32 领导团队还包括著名内分泌学家 Julianne Imperato-McGinley 博士、前 威尔康奈尔 CTSC 部门主管兼现任主任。然而，这项提议的推动力是 不是领导团队，而是那些令人难以置信的学员，他们一直在寻找学术之路 即使没有 T32 支持，药物也是如此。过去 10 年来，三位临床内分泌研究员成功 获得 K08 奖项，目前正在引领成功的学术研究生涯，尽管缺乏 可用的 T32；我们目前的一名第二年研究员甚至被选为进行第三年的研究培训 尽管我们的计划已被宣传为为期 2 年的临床计划，并且即将到来的临床计划 2022 年的研究员都是杰出的研究人员，其中一位拥有加州理工学院的博士学位，另一位拥有第一名 在我们的一位教师导师（罗博士）的指导下，作者在胰岛生物学方面发表了《自然医学》论文。我们 精心挑选了顶尖的研究导师团队，并设计了全面的教学培训 制定全方位指导计划，指导学员完成最终的 R01 提交。我们的招聘 计划很全面，并且非常重视招收顶尖的 URM 候选人。我们提出一个三 机构（WCM、MSKCC 和 RU），严格的多学科 T32 招收 2 名博士后 MD 或 Ph.D 受训者每年接受为期 2 年的培训。本次培训项目的领导者将与 以最大的热情和精力确保我们的学员发挥潜力并做出贡献 未来几年对内分泌学术界将产生重大影响。