POLYAMINES & CANCER

多胺

• 批准号: 3433942
• 负责人: LAURENCE J MARTON
• 金额: $ 0.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-06 至 1988-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3433942
• 关键词: neoplasm /cancer; polyamines; travel

Support is requested for the Seventh Biannual Gordon Research Conference on Polyamines. The uniquely successful interaction between basic and clinical scientists engaged in polyamine research has, in recent times, resulted in a tremendously expanded understanding of these fascinating and essential intracellular molecules, with a concomitant application of this knowledge to the therapy of human disease. The synthesis of specific inhibitors of polyamine biosynthesis such as alphadifluromethylornithine and analogues of the polyamines such as bisethylspermidine has allowed investigator to not only probe the function, biosynthesis, regulation, metabolism, etc. of these compounds, but to make meaningful inroads into cancer therapy. One of the first two National Cancer Drug Discovery Group Grants was awarded to a group focused on this area. This grant has made significant progress, with a clear demonstration of the viability of interaction between basic and clinical scientists. The planned Gordon Research Conference will focus, as in the past, on melding knowledge from many disciplines into focused ideas for future investigation. This Conference continually grows in popularity and representatives from many countries representing academic, industrial, and governmental agencies are always present. More than 90 posters were submitted for the last Conference (1985), in addition to a full slate of speakers. Obviously, the vast majority of attendees came with data and a sincere desire to interact.

请求为第七届戈登研究半年展提供支持 关于多胺的会议。独一无二的成功互动 在从事多胺研究的基础科学家和临床科学家之间 在最近的时间里，研究已经导致了一个巨大的 扩大对这些令人着迷和必要的 细胞内分子，伴随着这个的应用 对人类疾病治疗的认识。双环芳香烃的合成 多胺生物合成的特定抑制剂，如 α-二氟甲基鸟氨酸及其多胺类似物 例如双乙基亚精胺使研究人员不仅可以 探讨其功能、生物合成、调节、代谢等 这些化合物，但对癌症有意义的进展 心理治疗。首批两项国家抗癌药物发现之一 团体奖助金被授予一个专注于这一领域的团体。这 格兰特取得了重大进展，清楚地表明 基础科学家和临床科学家之间互动的可行性。 计划中的戈登研究会议将集中在 过去，将许多学科的知识融合在一起 对未来调查的想法。这个会议不断发展壮大 受欢迎的人和来自许多国家的代表 代表学术、工业和政府机构的是 永远都在。最后一届提交了90多张海报 会议(1985年)，此外还有一大批发言者。 显然，绝大多数与会者都带着数据和 真诚地想要互动。