2023 Polyamines Gordon Research Conference and Gordon Research Seminar

项目摘要 多胺戈登研究会议(GRC)自1975年以来一直在举行，并提供了 多学科论坛，汇聚了领先的多胺研究人员以及年轻和成熟的 调查人员是该领域的新手。2023年多胺GRC将在NH的沃特维尔山谷度假村举行，地点为 2023年6月25日至30日。这个GRC将广泛关注多胺在人类疾病中的作用， 主要关注癌症，包括癌症新陈代谢和免疫监测方面的突破 癌症预防和治疗、转移和癌症干细胞、蛋白质翻译和 以药物化学为基础的抗癌药物发现。其他人类疾病包括最近发现的几种 与多胺基因有关的先天性代谢性神经发育障碍，糖尿病，退行性疾病， 和病原体。这次会议的独特之处在于，它吸引了一系列评估 多胺在广泛的模型系统中的控制和作用(原核生物、寄生虫、 果蝇、植物、脊椎动物和哺乳动物)。多胺是一种小的、氨基酸衍生的聚阳离子，在 所有形式的生命，并在许多细胞过程中发挥重要作用，包括转录，翻译， 复制、新陈代谢、表观遗传控制和离子通道功能。2023年多胺GRC将 强调针对癌症和其他疾病中的多胺途径。该计划有很强的组合 基础、翻译和临床研究人员。参加GRC的有生物学家、化学家、内科医生- 科学家和临床医生，包括来自学术界、生物技术和制药部门的研究人员。这个 科学学科的多样性在GRC中是独一无二的，具有高度的刺激性，并将强调新的发现 与上游和下游通路有关，以及最近才与 多胺生物学。我们将带来最新的研究，新的调查人员，以及早期职业调查人员 来到这个论坛。在28位被点名的发言者中，有22位是自上次GRC以来的新人，他们从未和/或 早期职业科学家。我们还将从戈登研究研讨会(GRS)和 海报，这将增加更多的新演讲者。具体目标是寻求获得资金以支持42个GRC和15个 GRS注册，以及15名GRC/GRS参与者的旅费。我们的长远目标是加强 了解多胺代谢与人类疾病之间的相互作用，并加强 对来自不同背景的年轻科学家进行培训，使其成为多胺的贡献成员 科学界。特邀演讲者的演讲时间为25-30分钟，并有10分钟的讨论。 GRC将与第8届多胺联合举行，为研究生和研究员提供 学生运营的场所，促进数据和思想的交流。GRS通过以下方式使GRC体验更加丰富 在主会议期间提拔青年科学家。GRS和GRC与会者之间的互动促进 分享想法，建立新的伙伴关系，推动该领域向前发展。

Project Summary The Polyamines Gordon Research Conference (GRC) has run continuously since 1975 and provides a multidisciplinary forum that brings together leading polyamine researchers as well as young and established investigators new to the field. The 2023 Polyamines GRC will be held at Waterville Valley Resort in NH, from June 25-30, 2023. This GRC will have a broad focus on the role of polyamines in human diseases, with a major focus on cancer including breakthroughs in cancer metabolism and immune surveillance, advanced clinical trials for cancer prevention & treatment, metastasis and cancer stemness, protein translation, and medicinal chemistry-based cancer drug discovery. Other human diseases include several recently discovered inborn metabolic neurodevelopmental disorders linked to polyamine genes, diabetes, degenerative disorders, and pathogens. The meeting is unique in that it attracts a diverse array of top investigators assessing the control and roles of polyamines across a broad spectrum of model systems (prokaryotes, parasites, Drosophila, plants, vertebrates, and mammals). Polyamines are small, amino acid-derived polycations found in all forms of life and play essential roles in many cellular processes, including transcription, translation, replication, metabolism, epigenetic control, and ion channel functions. The 2023 Polyamines GRC will emphasize targeting polyamine pathways in cancer and other diseases. The Program has a strong mix of basic, translational, and clinical researchers. This GRC is attended by biologists, chemists, physician- scientists, and clinicians, and includes investigators from academia, biotech, and pharmaceutical sectors. The diversity of scientific disciplines is unique among GRCs, is highly stimulating, and will emphasize new findings relating to upstream and downstream pathways, and new diseases only recently linked to alterations in polyamine biology. We will bring the latest studies, new investigators to the field, and early career investigators to this forum. Of the 28 named speakers, 22 are new since the last GRC and have never spoken and/or are early career scientists. We will also choose 5 speakers from the Gordon Research Seminar (GRS) and the posters, which will add more new speakers. The specific aims seek to obtain funds to support 42 GRC & 15 GRS registrations, and travel costs for 15 GRC/GRS participants. The long-term objective is to enhance understanding of the interplay between polyamine metabolism and human diseases, and to enhance the training of young scientists from diverse backgrounds to become contributing members of the polyamine scientific community. Presentations by invited speakers will be 25-30 minutes, with a 10-minute discussion. The GRC will be held in conjunction with the 8th Polyamines, providing graduate students and fellows with a student-run venue that fosters exchange of data and ideas. The GRS makes the GRC a richer experience, by promoting young scientists during the main conference. Interactions between GRS & GRC conferees facilitate sharing of ideas and create new partnerships that will drive the field forward.