CONFERENCE ON CRYSTAL GROWTH OF BIOLOGICAL MACROMOLECULE

要求提供资金以支持十名青年学生的入学 美国科学家出席国际气候变化大会 生物大分子晶体生长将于7月举行， 1987年，在法国比琴贝格。首席调查员是一名 这次会议的组织者在两年前第一次 蛋白质晶体生长国际会议在北京举行 斯坦福大学(1985年8月)，他也是该校的联合组织者。 这次会议的目的是将学者们聚集在一起 以及致力于研究大分子的一般问题的科学家 结晶，讨论取得进展的技术基础 研究，并传播现有的知识，但 由于利益的多样性，很难获得 牵涉其中。这一话题对 生物化学和分子生物学研究界 因为它处理了三个决定的关键阶段 用X-射线衍射法测定蛋白质结构。 这些决定正在以越来越大的力量影响着 蛋白质工程、合理药物设计和未来的发展方向 利用重组DNA技术的其他领域的宿主。 蛋白质结构的测定本身就具有深远的意义 也很重要，因为它们提供了理解的基础 的体系结构原则和原子级机制 引导蛋白质的功能和调节。大会各届会议 将包括广泛的实际关注的主题，如新的 蛋白质结晶的技术、试剂和方法， 晶体成核和生长的理论，解释 经验和思想交流。还将包括会话 更狭隘地关注膜蛋白等主题 结晶，结晶到微重力， 大分子络合物的结晶和分子间的界面 关于蛋白质结晶的想法 传统的小分子。年轻的美国人出席 对这一领域感兴趣的调查人员对于确保 美国的结晶学和分子生物学 这次会议的好处和回报。

Funds are requested to support the attendance of ten young United States Scientists to the International Conference on the Crystal Growth of Biological Macromolecules to be held in July, 1987 at Bichenberg, France. The Principal Investigator is a co- organizer of this conference which follows by two years the First International Conference on Protein Crystal Growth held at Stanford University (August, 1985) which he also co-organized. The purpose of this conference is both to bring together scholars and scientists working on the general problem of macromolecular crystallization to discuss technical grounds for progress in research, and to disseminate knowledge currently available but rather difficult to obtain because of the diversity of interests involved. The topic is of substantial interest and significance to the biochemical and molecular biology research community because it treats a crucial phase in the determination of three dimensional protein structure by X-ray diffraction techniques. These determinations are impacting with increased force on the directions taken by protein engineering, rational drug design and a host of other fields employing recombinant DNA technology. Protein structure determinations are in themselves of profound importance as well, for they provide the basis of an understanding of the architectural principals and atomic levels mechanisms that guide protein function and regulation. Sessions at the Conference will include broad topics of practical concern such as new techniques, reagents, and approaches to protein crystallization, the theories of crystal nucleation and growth, an accounting of experiences, and exchange of ideas. Also included will be sessions more narrowly focused on topics such as membrane protein crystallization, crystallization to in microgravity, the crystallization of macromolecular complexes, and the interface of ideas relating protein crystallization the crystallization of conventional small molecules. Attendance by young American investigators interested in this field is essential to insuring that crystallography and molecular biology in the United States share in the benefits and rewards of this Conference.