CONFERENCE ON CRYSTAL GROWTH OF BIOLOGICAL MACROMOLECULE

要求提供资金，以支持10名年轻人出席会议。 美国科学家出席国际会议 生物高分子晶体生长将于7月举行， 1987年，法国比兴贝格。 首席研究员是一位合作者， 这次会议的组织者，这是继两年的第一次 蛋白质晶体生长国际会议在北京召开 斯坦福大学（1985年8月），他也共同组织。 这次会议的目的既是为了汇集学者 科学家们致力于解决大分子 结晶，讨论取得进展的技术基础， 研究和传播现有知识， 由于利益的多样性， 涉案 这一主题对以下方面具有重大意义和重要性： 生物化学和分子生物学研究界 因为它处理了决定三个 三维蛋白质结构的X射线衍射技术。 这些决定正在以更大的力量影响着 蛋白质工程、合理药物设计和 许多其他领域采用重组DNA技术。 蛋白质结构的确定本身就具有深远的意义。 重要性，因为它们提供了理解的基础 的架构原则和原子级机制， 指导蛋白质的功能和调节。 会议届会 将包括广泛的实际关注的问题，如新的 蛋白质结晶的技术、试剂和方法， 晶体成核与生长理论， 经验，交流思想。 还将包括会议 更狭隘地集中在膜蛋白等主题上， 在微重力下结晶， 大分子复合物的结晶，以及 有关蛋白质结晶的想法 传统的小分子。 美国青年出席 对这一领域感兴趣的调查人员必须确保， 美国晶体学和分子生物学分享 这次会议的好处和回报。

Funds are requested to support the attendance of ten young United States Scientists to the International Conference on the Crystal Growth of Biological Macromolecules to be held in July, 1987 at Bichenberg, France. The Principal Investigator is a co- organizer of this conference which follows by two years the First International Conference on Protein Crystal Growth held at Stanford University (August, 1985) which he also co-organized. The purpose of this conference is both to bring together scholars and scientists working on the general problem of macromolecular crystallization to discuss technical grounds for progress in research, and to disseminate knowledge currently available but rather difficult to obtain because of the diversity of interests involved. The topic is of substantial interest and significance to the biochemical and molecular biology research community because it treats a crucial phase in the determination of three dimensional protein structure by X-ray diffraction techniques. These determinations are impacting with increased force on the directions taken by protein engineering, rational drug design and a host of other fields employing recombinant DNA technology. Protein structure determinations are in themselves of profound importance as well, for they provide the basis of an understanding of the architectural principals and atomic levels mechanisms that guide protein function and regulation. Sessions at the Conference will include broad topics of practical concern such as new techniques, reagents, and approaches to protein crystallization, the theories of crystal nucleation and growth, an accounting of experiences, and exchange of ideas. Also included will be sessions more narrowly focused on topics such as membrane protein crystallization, crystallization to in microgravity, the crystallization of macromolecular complexes, and the interface of ideas relating protein crystallization the crystallization of conventional small molecules. Attendance by young American investigators interested in this field is essential to insuring that crystallography and molecular biology in the United States share in the benefits and rewards of this Conference.