FASEB CONFERENCE/GENETIC RECOMBINATION

该申请要求部分资金用于FASEB夏季 遗传修饰与基因组研究会议 重新安排，将于1987年6月28日至7月3日在铜举行 山，科罗拉多。 这次会议是在 美国实验生物学学会联合会 （FASEB）。 这次会议的形式将与上次会议相同 Gordon Research Conferences的一部分。 有九 邀请了36位演讲者。 各委员会主席 会议将介绍历史背景 和目前的问题，以使所有与会者了解 这个会议的主题。 海报展览会将于 会议 将安排小组信息工作坊 在会议之前或会议期间。 重点关注的生物体 包括噬菌体、细菌、真菌、原生动物、植物、昆虫 脊椎动物和哺乳动物细胞。 在体外和体内 方法将被覆盖。 重点将放在 哺乳动物细胞系统，特别是那些处理"基因"的系统， 靶向"和整合到基因组中。 更好的 理解后几点对于发展 目前正在探索的基因治疗策略， 用于各种人类先天性缺陷的实验室数量 新陈代谢的过程。 据我们所知，本次会议将 是美国唯一一个定期举行的会议， 将专门讨论基因重组和基因组 重新安排 所涉及的主题将是DNA突触的酶学; 真核转座;原核转座;位点特异性 重组;错配修复;同源重组 噬菌体、细菌和真菌;控制同源 重组;脊椎动物重组的医学应用; 以及重组的生物学后果，包括 控制基因表达。

This application request partial funding for a FASEB Summer Research Conference on Genetic Recombination and Genome Rearrangements, to be held June 28 - July 3, 1987 in Copper Mountain, Colorado. The conference is under the auspices of the Federation of the American Societies of Experimental Biology (FASEB). The format of this meeting will be the same as that used by the Gordon Research Conferences. There will be nine major sessions with 36 invited speakers. The chairperson of each session will give an introductory talk on the historical background and the current problems to acquaint all participants with the topics in that session. Poster sessions will be held throughout the meeting. Information workshops of small groups will be arranged before or at the meeting. The organisms to be focused upon include phage, bacteria, fungi, protozoa, plants, insects, vertebrates, and mammalian cells. Both in vitro and in vivo approaches will be covered. Emphasis will be placed on mammalian cell systems, especially those dealing with "gene targeting" and integration into the genome. A better understanding of these latter points is crucial for the development of gene therapy strategies which are currently being explored in a number of laboratories for use on a variety of human inborn errors of metabolism. To the best of our knowledge, this conference will be the only regularly scheduled meeting in the United States that will deal specifically with genetic recombination and genome rearrangements. The topics to be covered will be enzymology of DNA synapsis; eukaryotic transposition; prokaryotic transposition; site-specific recombination; mismatch repair; homologous recombination in phage, bacteria, and fungi; sites controlling homologous recombination; medical applications of vertebrate recombination; and the biological consequences of recombination, including the control of gene expression.