VASCULAR RESPONSES HETEROGENEITY IN SKELETAL MUSCLE

血液中的响应特性存在相当大的差异 船舶. 然而，几乎没有做什么来阐明这种变化， 骨骼肌血管和这种变化的生理功能 还有待确定。 本研究的总体目标是确定 内皮和非内皮依赖性反应， 骨骼肌供血血管中血管张力调节， 确定这些响应是否存在差异，这些差异可能与 在骨骼肌中发现的氧化能力的变化。 的 本研究的第一个目的是评估相似性的可能性， 最大血流量差异很大的肌肉之间的静息血流量 可能归因于肌源性张力或α肾上腺素受体的差异 介导的反应性。 第二个目标是评估 肌肉对血管扩张剂反应的差异 药物可能归因于肾上腺素能，毒蕈碱或 嘌呤能对它们的营养血管产生影响。 肌源性张力和张力 对这些特异性激动剂和阻断剂的反应的发展 将使用较大血管技术在体外测量受体。 将机械去除一半血管中的内皮素， 在另一半将进行验证。 剂量-反应 比目鱼肌营养血管和伸肌的特点 采用配对T分析比较趾长肌的供血血管。 的 这次调查的结果将加强我们对这两个问题的了解。 营养血管异质性的功能意义及其在 骨骼肌性能的局限性。

Considerable variation in response characteristics exists among blood vessels. However, little has been done to elucidate such variation in skeletal muscle vessels and the physiological function of such variations has yet to be established. The general aims of this study are to identify the endothelium and non-endothelium dependent responses which contribute to the regulation of vascular tone in skeletal muscle feed vessels and to determine if differences in these responses exist which may be related to the variation in oxidative capacity found among skeletal muscles. The first aim of this study is to evaluate the possibility that similarity in resting blood flow between muscles with very different maximal blood flow could be attributed to differences in myogenic tone or alpha adrenoreceptor mediated reactivity in their feed vessels. The second aim is to evaluate the possibility that differences in muscles' responses to vasodilator agents could be attributed to differences in adrenergic, muscarinic or purinergic influences on their feed vessels. Myogenic tension and tension development in response to agonists and blockers specific to these receptors will be measured in vitro using larger vessel techniques. Endothelium will be removed mechanically in half of the vessels and its presence will be verified in the other half. The dose-response characteristics of the soleus muscle's feed vessel and the extensor digitorum longus' feed vessel are compared using paired T analysis. The results of this investigation will enhance our understanding of both the functional significance of feed vessel heterogeneity and its role in the limitations of skeletal muscle performance.