All-in-One Smart Artificial Blood Vessels

一体化智能人造血管

• 批准号: EP/X027171/2
• 负责人: Molly Stevens
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2024
• 资助国家: 英国
• 起止时间: 2024 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX027171%2F2
• 关键词: Smart; Artificial; Blood; Vessels

Cardiovascular disease (CVDs) are the leading causes of disability and death worldwide. According to statistics from the World Heart Federation, more than 17.3 million people died from CVDs worldwide per year, accounting for 31% of the total global disease deaths. Vascular remodeling has great significance for the treatment of CVDs, but less than 30% of patients are eligible for autologous transplants, so artificial blood vessels become an indispensable alternative. Although structure-programmable textile artificial blood vessels are proved to qualify for clinical usage, problems such as inflammation, thrombus or blockage of artificial blood vessels are still threatening human life due to the inability to monitor blood vessel conditions. Therefore, the aim of this project is to develop all-in-one smart artificial blood vessel (SmartVessels) that can detect vessel conditions in real-time. The SmartVessels will be designed by combining electronic textile architecture design and bioengineering technology to achieve good compliance, biocompatibility, sustainability, and functionality. We will fabricate biocompatible conductive fibers, and process them into single-electrode triboelectric yarns, and use weaving technologies to fabricate hollow structured SmartVessels. The conductive fibers and triboelectric yarns in the fabric structure will enable wireless signal acquisition and transmission. When blood passes through the channel, electrical signals will be generated according to the electric double layer theory, thereby the blood flow velocity that reflect the vessels conditions can be evaluated and diagnosed. We envision a future where we will be able to detect and monitor CVDs in an early stage using textile artificial blood vessels.

心血管疾病是世界范围内导致残疾和死亡的主要原因。根据世界心脏联合会的统计，全球每年有超过1730万人死于心血管疾病，占全球疾病死亡总数的31%。血管重塑对心血管疾病的治疗具有重要意义，但只有不到30%的患者符合自体移植的条件，因此人工血管成为不可或缺的替代方案。尽管结构可编程纺织人工血管已被证明符合临床使用条件，但由于无法监测血管状况，炎症、血栓或人工血管堵塞等问题仍然威胁着人类的生命。因此，本项目的目的是开发能够实时检测血管状况的一体式智能人工血管(SmartVessels)。SmartVessels将结合电子纺织品架构设计和生物工程技术进行设计，以实现良好的合规性、生物兼容性、可持续性和功能性。我们将制造生物兼容的导电纤维，并将其加工成单电极摩擦电丝，并使用编织技术来制造中空结构的SmartVessels。织物结构中的导电纤维和摩擦电纱将实现无线信号采集和传输。当血液通过经络时，根据电双电层理论产生电信号，从而可以对反映血管状况的血流速度进行评估和诊断。我们展望了未来，我们将能够使用纺织人造血管在早期阶段检测和监测心血管疾病。