CONFERENCE ON SUBSTANCE P & RELATED PEPTIDES

P 物质会议

• 批准号: 3436155
• 负责人: SUSAN E LEEMAN
• 金额: $ 1.5万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3436155
• 关键词: autonomic agents; biological signal transduction; electrophysiology; gene expression; heart circulation; immunoregulation; inflammatory bowel diseases; meeting /conference /symposium; messenger RNA; neurochemistry; neuropeptide receptor; neuropeptides; neuropharmacologic agent; neurotransmitter receptor; peptidases; protein signal sequence; substance P; tachykinin

This proposal requests support for a conference on "Substance P related peptides: Cellular and molecular physiology." The meeting will be held in Worcester, Massachusetts on July 19-21, 1990, and will bring together a large group of nationally and internationally recognized scientists working in the area, including physiologists, pharmacologists, biochemists and molecular biologists. The scope of the meeting will be on recent advances in the field. The structures, expression and regulation of the two preprotachykinin genes will be addressed, as will the different patterns of posttranslational processing of the multiple precursors. A major focus will be on the molecular biological, biochemical and pharmacological characterization of the multiple receptors for substance P and related peptides. Progress has continued on the development of antagonists permitting new studies on the physiological roles of substance P. Several highly selective peptide-based receptor antagonists have been defined over the past two years, and an exciting recent achievement has been the identification of non-peptide receptor antagonists. Several studies related to these antagonists will be reported at this meeting. Signal transduction mechanisms will be presented from biochemical and electrophysiological points of view. The anatomical localization of the peptides and their receptors, and their cognate mRNAs, as well as their colocalization with other neurotransmitter systems, will be addressed. Finally, the many functions of Substance P and related peptides in specific central nervous regions, in the sensory and the autonomic nervous systems, in the reproductive tract, and in regulation of immune function, will be covered. Substance P has been implicated in the transmission of painful stimuli, in inflammatory responses, in arthritis and in inflammatory bowel disease. Substance P fibers innervate the vasculature including the coronary circulation. Thus the possible clinical implications of substance P will be considered. It is hoped that this meeting will attract many younger persons including graduate students, postdoctoral fellows and junior faculty members to attend and participate in the scheduled poster sessions. The requested funds will used to help defray expenses for these younger scientists.

该提案请求支持关于“物质 P 相关”的会议 肽：细胞和分子生理学。”会议将于 1990 年 7 月 19 日至 21 日在马萨诸塞州伍斯特举行，并将汇集 一大批国内和国际公认的科学家在工作 该领域的专家，包括生理学家、药理学家、生物化学家和 分子生物学家。 会议范围将讨论最新进展 在外地。 两者的结构、表达及调控 前原速激肽基因将得到解决，不同的模式也将得到解决 多个前体的翻译后加工。 一大焦点 将在分子生物学、生物化学和药理学方面 P 物质及相关物质的多种受体的表征 肽。 拮抗剂的开发持续取得进展 允许对 P 物质的生理作用进行新的研究。 高度选择性的基于肽的受体拮抗剂已被定义 过去两年，最近一项令人兴奋的成就是 非肽受体拮抗剂的鉴定。 多项研究 与这些拮抗剂相关的信息将在本次会议上报告。 信号 转导机制将从生化和 电生理学的观点。 的解剖定位 肽及其受体，及其同源 mRNA，以及它们的 将解决与其他神经递质系统的共定位问题。 最后，P物质及相关肽在特定领域的多种功能 中枢神经区域，在感觉和自主神经系统中， 在生殖道和免疫功能的调节中， 覆盖。 P物质与疼痛的传播有关 刺激、炎症反应、关节炎和炎症性肠 疾病。 P物质纤维支配脉管系统，包括 冠脉循环。 因此，物质可能的临床意义 将考虑 P。 希望这次会议能够吸引更多的年轻人，包括 研究生、博士后和初级教员 出席并参加预定​​的海报会议。 所要求的 资金将用于帮助支付这些年轻科学家的费用。