CONFERENCE ON SUBSTANCE P & RELATED PEPTIDES

该提案请求支持召开一次关于“与P物质有关的”的会议 多肽：细胞和分子生理学。会议将在 将于1990年7月19日至21日在马萨诸塞州的伍斯特举行，并将汇集一位 一大批国内和国际公认的科学家在工作 在该地区，包括生理学家、药理学家、生物化学家和 分子生物学家。会议的范围将围绕最近的进展展开。 在战场上。两者的结构、表达和调控 原速激肽原基因将被解决，以及不同模式的 多个前兆的翻译后处理。一个主要的焦点 将对分子生物学、生化和药理学进行研究 P物质及其相关多受体的特性研究 多肽。在开发拮抗剂方面继续取得进展 允许对P物质的生理作用进行新的研究 高选择性的基于多肽的受体拮抗剂已经被定义为 在过去的两年里，最近一个令人兴奋的成就是 非肽受体拮抗剂的鉴定。几项研究 与这些拮抗剂相关的信息将在这次会议上报告。讯号 转导机制将从生物化学和生物化学两个方面进行阐述。 电生理学观点。颈椎的解剖学定位 多肽及其受体，它们的同源mRNAs，以及它们的 与其他神经递质系统的共址，将被解决。 最后，P物质及相关多肽在体内的多种功能。 中枢神经区域，在感觉和自主神经系统中， 在生殖道中，在免疫功能的调节中， 盖好了。P物质与疼痛的传递有关 刺激、炎症反应、关节炎和炎症性肠炎 疾病。P物质纤维支配血管系统，包括 冠状循环。因此，物质可能的临床意义 P将被考虑。 希望这次会议将吸引许多年轻人，包括 研究生、博士后研究员和初级教职员工 出席并参与预定的海报会议。所请求的 资金将用于支付这些年轻科学家的费用。

This proposal requests support for a conference on "Substance P related peptides: Cellular and molecular physiology." The meeting will be held in Worcester, Massachusetts on July 19-21, 1990, and will bring together a large group of nationally and internationally recognized scientists working in the area, including physiologists, pharmacologists, biochemists and molecular biologists. The scope of the meeting will be on recent advances in the field. The structures, expression and regulation of the two preprotachykinin genes will be addressed, as will the different patterns of posttranslational processing of the multiple precursors. A major focus will be on the molecular biological, biochemical and pharmacological characterization of the multiple receptors for substance P and related peptides. Progress has continued on the development of antagonists permitting new studies on the physiological roles of substance P. Several highly selective peptide-based receptor antagonists have been defined over the past two years, and an exciting recent achievement has been the identification of non-peptide receptor antagonists. Several studies related to these antagonists will be reported at this meeting. Signal transduction mechanisms will be presented from biochemical and electrophysiological points of view. The anatomical localization of the peptides and their receptors, and their cognate mRNAs, as well as their colocalization with other neurotransmitter systems, will be addressed. Finally, the many functions of Substance P and related peptides in specific central nervous regions, in the sensory and the autonomic nervous systems, in the reproductive tract, and in regulation of immune function, will be covered. Substance P has been implicated in the transmission of painful stimuli, in inflammatory responses, in arthritis and in inflammatory bowel disease. Substance P fibers innervate the vasculature including the coronary circulation. Thus the possible clinical implications of substance P will be considered. It is hoped that this meeting will attract many younger persons including graduate students, postdoctoral fellows and junior faculty members to attend and participate in the scheduled poster sessions. The requested funds will used to help defray expenses for these younger scientists.