PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES
PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES
批准号:
3229095
负责人:
SUSAN E LEEMAN
金额:
$31.32万
依托单位国家:
美国
项目类别:
财政年份:
1980
资助国家:
美国
项目状态:
已结题
起止时间:
1980-12-01 至 1992-05-31
中文摘要
在持续的研究中,计划进行几个系列的实验
两种多肽,P物质和神经降压素,最初是
在本实验室中分离和化学定义,以及
多肽,物质K,它在同一个基因中编码,与
这些多肽具有广泛性和选择性。
中枢和外周神经系统的分布
和几个内分泌组织表明这些多肽
服从多种生理角色。建议进行的研究
包括:1)阐明神经降压素在中枢神经系统中的作用
促黄体生成素释放的调节;2)SP和SK的内分泌调节
基因在垂体前叶和精选神经中的表达
发育过程中的组织及其分布和功能
垂体前叶中SP的表达;以及3)纯化和
SP(和SK)受体的生化特性。进一步
对P物质和NT在大鼠脑内的生理作用的认识(S)
下丘脑和垂体前叶应该对我们的
了解这些结构所规定的功能。
了解激素对多肽基因调控的影响
在发育过程中的表达应该提供重要的见解
研究神经肽和荷尔蒙多肽如何对
成熟期的内分泌环境。分离和化学
SP(和SK)受体的特征将提供一个主要的
向了解这些多肽调节的过程迈进一步-
受体相互作用。由于SP(和SK)扮演着重要角色,因此
例如,在痛苦刺激的传递中,化学物质
对这些肽的活性结合部位的定义可能导致
开发新的治疗方法。
英文摘要
Several series of experiments are planned in continuing research
on two peptides, substance P and neurotensin, that were originally
isolated and chemically defined in this laboratory as well as the
peptides, substance K, which is coded for in the same gene as
substance P. These peptides have widespread but selective
distribution throughout the central and peripheral nervous system
and several endocrine tissues suggesting that these peptides
subserve multiple physiological roles. The proposed studies
include: 1) elucidation of the role of neurotensin in the central
regulation of LH release; 2) endocrine regulation of SP and SK
gene expression in the anterior pituitary and selected neural
tissues during development as well as the distribution and function
of SP in the anterior pituitary; and, 3) purification and
biochemical characterization of SP (and SK) receptors. Further
understanding of the physiological role(s) of substance P and NT in
the hypothalamus and anterior pituitary should contribute to our
understanding of the functions regulated by these structures.
Understanding hormonal effects on the regulation of peptide gene
expression during development should provide important insights
into how neural and hormonal peptides respond to changes in
endocrine milieu during maturation. The isolation and chemical
characterization of the SP (and SK) receptor will provide a major
step towards understanding processes regulated by these peptide-
receptor interactions. Since SP (and SK) play important roles, for
example, in the transmission of painful stimuli, the chemical
definition of the active binding site of these peptides may lead to
the development of new therapeutic approaches.
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会议论文
CHARACTERIZATION OF GLYCOSYLATION PATTERN OF NK1 RECEPTOR
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批准号:6978467
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项目类别:
-
资助金额:$0.24万
-
财政年份:2004
-
负责人:SUSAN E LEEMAN
-
依托单位:
Glycosylation of NK1 Receptors: Chemistry and Function
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批准号:6611692
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项目类别:
-
资助金额:$20.19万
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财政年份:2003
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负责人:SUSAN E LEEMAN
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依托单位:
Glycosylation of NK1 Receptors: Chemistry and Function
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批准号:6703730
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项目类别:
-
资助金额:$20.19万
-
财政年份:2003
-
负责人:SUSAN E LEEMAN
-
依托单位:
MOLECULAR BIOLOGICAL STUDIES ON PEPTIDE
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批准号:2291920
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项目类别:
-
资助金额:$2.42万
-
财政年份:1994
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负责人:SUSAN E LEEMAN
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依托单位:
PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES
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批准号:3229105
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项目类别:
-
资助金额:$4.28万
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财政年份:1992
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负责人:SUSAN E LEEMAN
-
依托单位:
PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES
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批准号:3229099
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项目类别:
-
资助金额:$0.39万
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财政年份:1990
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负责人:SUSAN E LEEMAN
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依托单位:
CONFERENCE ON SUBSTANCE P & RELATED PEPTIDES
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批准号:3436155
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项目类别:
-
资助金额:$1.5万
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财政年份:1990
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负责人:SUSAN E LEEMAN
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依托单位:
NEUROTENSIN AND FEMALE-SPECIFIC LH SECRETION
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批准号:3229098
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项目类别:
-
资助金额:$22.11万
-
财政年份:1980
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负责人:SUSAN E LEEMAN
-
依托单位:
PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES
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批准号:3229102
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项目类别:
-
资助金额:$34.96万
-
财政年份:1980
-
负责人:SUSAN E LEEMAN
-
依托单位:
PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES
-
批准号:3229103
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项目类别:
-
资助金额:$36.41万
-
财政年份:1980
-
负责人:SUSAN E LEEMAN
-
依托单位:
PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES
-
批准号:3229104
-
项目类别:
-
资助金额:$32.13万
-
财政年份:1980
-
负责人:SUSAN E LEEMAN
-
依托单位:
PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES
-
批准号:3229100
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项目类别:
-
资助金额:$29.44万
-
财政年份:1980
-
负责人:SUSAN E LEEMAN
-
依托单位:
PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES
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批准号:3229101
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项目类别:
-
资助金额:$33.36万
-
财政年份:1980
-
负责人:SUSAN E LEEMAN
-
依托单位:
PURIFICATION AND FUNCTION OF HYPOTHALAMIC PEPTIDES
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批准号:3151978
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项目类别:
-
资助金额:$32.04万
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财政年份:1980
-
负责人:SUSAN E LEEMAN
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依托单位:
NEUROTENSIN AND FEMALE-SPECIFIC LH SECRETION
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批准号:2138251
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项目类别:
-
资助金额:$24.64万
-
财政年份:1980
-
负责人:SUSAN E LEEMAN
-
依托单位:
NEUROTENSIN AND FEMALE-SPECIFIC LH SECRETION
-
批准号:2138250
-
项目类别:
-
资助金额:$23.01万
-
财政年份:1980
-
负责人:SUSAN E LEEMAN
-
依托单位:
海外基金