NEUROLOGICAL AND NEUROPSYCHOLOGICAL ASPECTS OF HIV

HIV 的神经学和神经心理学方面

• 批准号: 3436158
• 负责人: ROBERT M LEVY
• 金额: $ 3万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1991-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3436158
• 关键词: AIDS; Canada; HIV infections; medical complication; nervous system infection; neuropsychology; neurotropic virus; travel

Infection with the human immunodeficiency virus (HIV-1) results not only in immunologic dysfunction but also in neurological and neuropsychological illness. Ten percent of all patients with the acquired immunodeficiency syndrome (AIDS) have a neurological complaint as their first sign of illness, 37% of AIDS patients have significant neurological dysfunction during their lifetime and 75% have neuropathological abnormalities on autopsy. Neuropsychological abnormalities have been reported in 8% to 67% of patients with AIDS and in 10% to 40% of people with HIV-1 infection. Neurological illness arises not only as a result of opportunistic processes but also as a result of primary HIV-1 infection of the nervous system. Thus, the large numbers of people infected with HIV-1 are also at risk of developing neurological or neuropsychological illness, even in the absence of immunological dysfunction or systemic illness. Since the first reports of HIV-1-related neurological illness in 1983, research into the neurological and neuropsychological complications of AIDS and HIV-1 infection has provided a number of new insights into the mechanisms and clinical manifestations of HIV-1 infection of the nervous system. The goal of Neurological and Neuropsychological Aspects of HIV Infection, an annual satellite meeting prior to the annual International Conference on AIDS, is to bring together the world's experts in various aspects of HIV infection and its neurological and neuropsychological complications. This meeting will begin with several plenary talks which will review the most important recent results of research in these areas. During the open scientific sessions which will follow, researchers from around the world will be able to share the results of their research in this field and have a forum for the discussion of this research. On a biyearly basis, the first day of this three day meeting will consist of an overview course on the neurological and neuropsychological complications of AIDS and HIV infection, presented by the world's experts in these areas. This international scientific meeting should result in an increased awareness of the neurological and neuropsychological aspects of AIDS and HIV infection; this increased awareness should result in improved care of patients with HIV infection as well as directing and coordinating future research into this critical area. Our first annual meeting in Quebec City, prior to the Vth International Conference on AIDS in Montreal, was an unqualified success with over 220 participants from around the world. With this overwhelming initial response, we plan to continue the Neurological and Neuropsychological Aspects

感染人类免疫缺陷病毒（HIV-1）不仅导致 免疫功能障碍，而且在神经学和神经心理学方面 病10%的获得性免疫缺陷患者 综合征（艾滋病）有一个神经系统的投诉作为他们的第一个迹象， 患病时，37%的艾滋病患者有明显的神经功能障碍 在他们的一生中，75%的人有神经病理学异常， 尸检据报道，8%至67%的患者存在神经心理异常 艾滋病患者和10%至40%的HIV-1感染者。 神经系统疾病的出现不仅是机会性过程的结果 也是神经系统原发性HIV-1感染的结果。 因此，大量感染HIV-1的人也有感染艾滋病毒的危险。 发展神经或神经心理疾病，即使没有 免疫功能紊乱或系统性疾病的症状 自从1983年首次报道HIV-1相关的神经系统疾病以来， 研究艾滋病的神经和神经心理并发症 和HIV-1感染提供了一些新的见解， 神经系统HIV-1感染的机制和临床表现 系统HIV的神经学和神经心理学方面的目标 感染，每年的卫星会议之前，每年的国际 艾滋病会议，是为了汇集世界各地的专家， 艾滋病毒感染及其神经和神经心理学方面 并发症本次会议开始将举行几次全体会议， 将回顾这些领域最重要的最新研究成果。 在随后的公开科学会议上，来自 世界各地的研究人员将能够分享他们的研究成果， 这一领域，并有一个论坛，讨论这项研究。上 每两年举行一次，为期三天的会议的第一天将包括一个 神经和神经心理并发症概述课程 艾滋病和艾滋病病毒感染，由世界上这些领域的专家介绍。 这次国际科学会议将增加 对艾滋病的神经和神经心理方面的认识， 艾滋病毒感染;这一提高认识应导致改善护理 艾滋病毒感染者以及指导和协调未来 对这一关键领域的研究。我们在魁北克市的第一次年会， 在蒙特利尔举行的第五届国际艾滋病大会之前， 来自世界各地的220多名参与者取得了圆满成功。与 这种压倒性的初步反应，我们计划继续神经学 神经心理学方面