GORDON RESEARCH CONFERENCE ON MUTAGENESIS, 1992

这项提案要求提供资金，以支持科学家前往 第八届戈登诱变研究会议，普利茅斯 1992年6月29日至7月3日，新罕布夏州州立学院。目的 会议的目的是提供一个讲演和讨论的论坛。 在对突变感兴趣的科学家中，为了产生新的 视角、新想法和互动。约135名与会者是 来自大学、科研院所、行业和政府的期望 世界各地的经纪公司。1992年会议将强调努力 从分子水平上理解突变，关注最近的 利用高分辨化学、结构、生化和 遗传方法。该计划将探索与以下方面相关的关键概念 错误辨别的结构和酶学基础， 复制、重组、转座和几个 DNA修复的类型到突变，DNA的分子细节是如何 损伤被处理成突变，几个专门的突变 对生存至关重要的过程，以及人类的突变基础 遗传性疾病，包括癌症。阐明突变机制是 对于理解各种有害的 以及基因信息变化的有益后果。

This proposal requests funds to support the travel of scientists to the eighth biannual Gordon Research Conference on Mutagenesis, at Plymouth State College, New Hampshire, on June 29-July 3, 1992. The purpose of the conference is to provide a forum for presentations by and discussions among scientists interested in mutagenesis, in order to generate fresh perspectives and new ideas and interactions. About 135 attendees are expected from universities, research institutes, industry and government agencies around the world. The 1992 Conference will emphasize attempts to understand mutagenesis at the molecular level by focusing on recent progress using highresolution chemical, structural, biochemical and genetical approaches. The program will explore key concepts relating to the structural and enzymological basis of error discrimination, the relationship among replication, recombination, transposition and several types of DNA repair to mutagenesis, the molecular details of how DNA damage is processed into mutations, several specialized mutational processes critical for survival, and the mutational basis of human genetic diseases, including cancer. Elucidating mutational mechanisms is of fundamental importance for understanding a variety of both deleterious and beneficial consequences of alterations in genetic information.