GORDON RESEARCH CONFERENCE ON MUTAGENESIS, 1992

该提案要求提供资金，以支持科学家前往 第八届两年一度的戈登突变研究会议，普利茅斯 州立大学，新罕布什尔州，1992年6月29日至7月3日。 的目的 会议将提供一个论坛， 在对诱变感兴趣的科学家中， 观点和新的想法和互动。 约135名与会者 期望来自大学、研究机构、工业和政府 世界各地的机构。 1992年会议将强调努力 为了在分子水平上理解诱变， 利用高分辨率的化学、结构、生物化学和 遗传学方法。 该计划将探讨有关的关键概念， 错误判别的结构和酶学基础， 复制、重组、转座和几个 DNA修复的类型突变，DNA如何修复的分子细节 损伤被加工成突变，几个专门的突变 对生存至关重要的过程，以及人类基因突变的基础 遗传疾病，包括癌症。 阐明突变机制是 对于理解各种有害的 以及遗传信息改变的有益后果。

This proposal requests funds to support the travel of scientists to the eighth biannual Gordon Research Conference on Mutagenesis, at Plymouth State College, New Hampshire, on June 29-July 3, 1992. The purpose of the conference is to provide a forum for presentations by and discussions among scientists interested in mutagenesis, in order to generate fresh perspectives and new ideas and interactions. About 135 attendees are expected from universities, research institutes, industry and government agencies around the world. The 1992 Conference will emphasize attempts to understand mutagenesis at the molecular level by focusing on recent progress using highresolution chemical, structural, biochemical and genetical approaches. The program will explore key concepts relating to the structural and enzymological basis of error discrimination, the relationship among replication, recombination, transposition and several types of DNA repair to mutagenesis, the molecular details of how DNA damage is processed into mutations, several specialized mutational processes critical for survival, and the mutational basis of human genetic diseases, including cancer. Elucidating mutational mechanisms is of fundamental importance for understanding a variety of both deleterious and beneficial consequences of alterations in genetic information.