GORDON RESEARCH CONFERENCE ON MUTAGENESIS, 1992

该提案要求提供资金支持科学家前往 第八届一年两次的戈登诱变研究会议，在普利茅斯举行 新罕布什尔州州立学院，1992 年 6 月 29 日至 7 月 3 日。 会议旨在提供一个供发言和讨论的论坛 对诱变感兴趣的科学家之间，为了产生新鲜的 观点、新想法和互动。 约 135 名与会者 大学、科研院所、行业和政府的期望 世界各地的机构。 1992年会议将强调尝试 通过关注最近的研究来了解分子水平上的诱变 使用高分辨率化学、结构、生物化学和 遗传方法。 该计划将探讨相关的关键概念 错误辨别的结构和酶学基础， 复制、重组、转座等之间的关系 DNA 修复到诱变的类型，DNA 修复的分子细节 损伤被加工成突变，几种专门的突变 对生存至关重要的过程以及人类的突变基础 遗传疾病，包括癌症。 阐明突变机制是 对于理解各种有害物质具有根本重要性 以及遗传信息改变的有益后果。

This proposal requests funds to support the travel of scientists to the eighth biannual Gordon Research Conference on Mutagenesis, at Plymouth State College, New Hampshire, on June 29-July 3, 1992. The purpose of the conference is to provide a forum for presentations by and discussions among scientists interested in mutagenesis, in order to generate fresh perspectives and new ideas and interactions. About 135 attendees are expected from universities, research institutes, industry and government agencies around the world. The 1992 Conference will emphasize attempts to understand mutagenesis at the molecular level by focusing on recent progress using highresolution chemical, structural, biochemical and genetical approaches. The program will explore key concepts relating to the structural and enzymological basis of error discrimination, the relationship among replication, recombination, transposition and several types of DNA repair to mutagenesis, the molecular details of how DNA damage is processed into mutations, several specialized mutational processes critical for survival, and the mutational basis of human genetic diseases, including cancer. Elucidating mutational mechanisms is of fundamental importance for understanding a variety of both deleterious and beneficial consequences of alterations in genetic information.