Core D: Research Experience and Training Coordination Core

项目概要/摘要-研究经验和培训协调核心 N-亚硝胺是一个化学家族，其中包括一些已知的最有效的诱变剂。亚硝胺 是奥林化学超级基金场地附近居民的主要担忧，也是 帕萨马科迪部落，因为他们的饮用水所使用的水处理方法是众所周知的， 形成N-亚硝胺。研究经验和培训协调中心的使命 （RETCC）是招聘，培训和从事生物医学研究职业的最好和最聪明的学生 (BMR)环境科学与工程（ESE），重点是公共卫生。的支持下 在RETCC中，学员将参加所有拟议的研究、参与和翻译活动， 将为数据管理和分析核心（DMAC）贡献数据并从中受益。因此，受训者 整个MIT SRP项目通过促进和促成受训人员之间以及受训人员与 作为领导者，RETCC支持子系统之间相互依赖的创新系统方法 （项目和核心）。通过系统方法，所有受训人员都影响所有项目并受到所有项目的影响， 核心通过由管理核心和DMAC建立的连接网络。生成的数据 将由数据管理和分析核心管理，并将与来自 该计划的其他部分有助于风险评估。创新的方面包括跨- 学科研究机会，如何利用研究影响政策的培训，以及新的“麻省理工学院” SRP探索计划”，使学员能够花时间在其他麻省理工学院的实验室。此外还将 有几种方法来支持管道的发展，以增加不同的尖子生的数量， 在环境健康科学和工程方面追求职业生涯的背景和专业知识。这项工作将 包括创造一个麻省理工学院本科生研究机会，重点是SRP研究，一个新的“公共卫生 民主化”管道项目，以连接URM SRP学员与年轻的URM学生。具体目标1 为学员提供研究、翻译、社区参与和数据的机会 这将有助于保护人类健康免受有害化学品的危害。具体目标2是加强 并制定促进专业发展的计划。具体目标3是招聘和晋升 不同的学生和博士后。具体目标4是提供正式培训，以确保MIT SRP 受训人员在生物医学研究和环境科学方面有成功和负责任的职业生涯 与工程学行政核心将为受训人员提供参与研究的机会 翻译，包括与利益相关者的互动。社区参与核心（CEC） 将为学员与社区成员合作打开大门，包括帮助部署传感器和过滤器。 破坏N-亚硝胺的装置。总的来说，RETCC为学员提供了基础， 并使整个计划的集体影响。

PROJECT SUMMARY/ABSTRACT – RESEARCH EXPERIENCE AND TRAINING COORDINATION CORE N-Nitrosamines are a family of chemicals that include some of the most potent mutagens known. N-Nitrosamines are a major concern for people who live near the Olin Chemical Superfund Site, and they are also a concern of the Passamaquoddy Tribe, because the water treatment methods used for their drinking water are known to lead to formation of N-nitrosamines. The mission of the Research Experience and Training Coordination Core (RETCC) is to recruit, train, and engage the best and the brightest students for careers in Biomedical Research (BMR) and Environmental Science and Engineering (ESE) with a focus on public health. With support from the RETCC, trainees will participate in all of the proposed research, engagement, and translation activities, and they will contribute data to and benefit from the Data Management and Analysis Core (DMAC). As such, trainees fuel the entire MIT SRP program. By fostering and enabling interactions among trainees and between trainees and leaders, the RETCC supports an innovative Systems Approach of inter-dependencies among subsystems (Projects and Cores). Via a Systems Approach, all trainees impact and are impacted by all of the Projects and Cores via a network of connections that are fostered by the Administrative Core and the DMAC. Data generated by trainees will be managed by the Data Management and Analysis Core and will be integrated with data from other parts of the program to contribute to risk evaluation. Innovative aspects of the RETCC include cross- disciplinary research opportunities, training in how research can be leveraged to impact policy, and a new “MIT SRP Exploration Program” that enables trainees to spend time in other MIT laboratories. In addition, there will be several approaches to support pipeline development so as to increase the number of top students with diverse backgrounds and expertise pursuing careers in environmental health sciences and engineering. This work will include creating an MIT undergraduate research opportunity that focuses on SRP research, a new “Public Health Democratization” Pipeline Project to connect URM SRP Trainees with younger URM students. Specific Aim 1 is to provide opportunities to trainees for research, translation, community engagement, and data analysis that will help protect human health from hazardous chemicals. Specific Aim 2 is to strengthen and create programs to promote professional development. Specific Aim 3 is to recruit and promote diverse students and postdocs. Specific Aim 4 is to provide formal training to ensure that MIT SRP trainees have successful and responsible careers in biomedical research and environmental science and engineering. The Administrative Core will foster opportunities for trainees to participate in research translation, which includes interactions with stakeholders. Furthermore, the Community Engagement Core (CEC) will open doors for trainees to work with community members, including helping to deploy sensors and a filtration device that will destroy N-nitrosamines. Taken together, the RETCC provides the foundation upon which trainees thrive and enables the collective impact of the entire program.